> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/tlr4-661eba21-4c38-5c0b-8deb-f67b52ab14b6
> Record changed: 2026-11-04

# TLR4

ENSG00000136869

Target class

Membrane receptor

Chromosome

9

Approved drugs

0

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

0

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

TLR4

**Gene name**

Toll like receptor 4

**Gene symbol**

TLR4

**Protein name**

Toll-like receptor 4 (hToll) (CD antigen CD284)

### Other names (4)

- hToll
- CD284
- TLR-4
- ARMD10

## Classification

**Gene biotype**

Protein coding

**Gene family**

CD molecules|Toll like receptors

**Target class**

Membrane receptor

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

52

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

40.49

**Tissue specificity (Gini)**

0.435

**Tissue specificity (tau)**

0.794

## Pathways and interactions

**KEGG gene identifiers**

- hsa:7099

**Protein interaction confidence**

0.85544

**Protein interaction partners**

218

### Reactome pathways (18)

- R-HSA-1236974
- R-HSA-140534
- R-HSA-166016
- R-HSA-166058
- R-HSA-166166
- R-HSA-2562578
- R-HSA-5602498
- R-HSA-5603041
- R-HSA-5686938
- R-HSA-936964
- R-HSA-937041
- R-HSA-937072
- R-HSA-9707616
- R-HSA-975163
- R-HSA-9820960
- R-HSA-9824878
- R-HSA-9833110
- R-HSA-9918481

## Genomic location

**End position**

117724735

**Start position**

117704175

**Chromosome**

9

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000136869

**HGNC ID**

HGNC:11850

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11850)

**NCBI Gene ID**

7099

**UniProt ID**

O00206

## Cellular location

- Cell membrane
- Single-pass type I membrane protein . Early endosome . Cell projection, ruffle . Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584). Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation. Co-localizes with ZG16B/PAUF at the cell membrane of pancreatic cancer cells (PubMed:36232715). .
- Plasma membrane

### Publication evidence (9)

- PubMed 11274165  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11274165/)
- PubMed 17098818  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17098818/)
- PubMed 20037584  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20037584/)
- PubMed 21393102  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21393102/)
- PubMed 27022195  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27022195/)
- PubMed 36232715  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36232715/)
- PubMed 36945827  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36945827/)
- PubMed 38670073  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38670073/)
- PubMed 9237759  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9237759/)

## Tissue expression

**Tissue specificity (tau)**

0.794019

**Expression inequality (Gini)**

0.434607

### Highest expression

Expression in transcripts per million

**Spleen**

40.49

**Whole Blood**

40.08

**Adipose - Visceral (Omentum)**

27.58

**Lung**

23.4

**Adipose - Subcutaneous**

23.25

### All tissues (54)

Expression in transcripts per million

- Spleen40.49
- Whole Blood40.08
- Adipose - Visceral (Omentum)27.58
- Lung23.4
- Adipose - Subcutaneous23.25
- Cells - Cultured fibroblasts21.55
- Breast - Mammary Tissue19.23
- Artery - Aorta17.34
- Artery - Coronary15.84
- Thyroid11.93
- Nerve - Tibial10.72
- Adrenal Gland9.99
- Minor Salivary Gland9.51
- Cervix - Endocervix8.38
- Uterus8.16
- Esophagus - Gastroesophageal Junction8.03
- Bladder7.93
- Fallopian Tube7.89
- Small Intestine - Terminal Ileum7.57
- Ovary7.52
- Brain - Caudate (basal ganglia)7.41
- Esophagus - Muscularis7.4
- Artery - Tibial7.22
- Prostate6.89
- Kidney - Medulla6.76

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (32)

- GO:0002224  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002224)
- GO:0002755  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002755)
- GO:0006909  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006909)
- GO:0006954  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954)
- GO:0006955  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955)
- GO:0010628  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628)
- GO:0031663  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031663)
- GO:0032496  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032496)
- GO:0032497  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032497)
- GO:0032722  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032722)
- GO:0032731  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032731)
- GO:0032735  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032735)
- GO:0032755  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032755)
- GO:0032757  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032757)
- GO:0032760  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032760)
- GO:0034142  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034142)
- GO:0042116  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042116)
- GO:0042742  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042742)
- GO:0043123  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123)
- GO:0045087  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045087)
- GO:0045944  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944)
- GO:0050729  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050729)
- GO:0050829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050829)
- GO:0071222  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071222)
- GO:0071260  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071260)

And 7 more, listed on the interactive page.

### Cellular components (9)

- GO:0001891  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001891)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0009897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009897)
- GO:0009986  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986)
- GO:0010008  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008)
- GO:0043235  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235)
- GO:0046696  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046696)
- GO:0048471  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471)

### Molecular functions (9)

- GO:0001530  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001530)
- GO:0001540  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001540)
- GO:0001875  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001875)
- GO:0004888  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888)
- GO:0005102  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0038023  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038023)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)
- GO:0046982  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982)

## Related records

### Trials (16)

- A Phase I, 2-part (Part 1 Being a Single Dose Escalation and Part 2, a Parallel Group) Study of Toll-like Receptor (TLR4) Agonist (GSK1795091) in Healthy Subjects
- A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis
- A Study of Eritoran (E5564) Administered IV Over 14 Days Prior to and During Bone Marrow Engraftment in BMT Patients Who Have Received Myeloablative Conditioning Treatment and Are Receiving Bone Marrow or Stem Cells From Matched Related Donors
- A-TANGO Phase 2 Study
- ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis
- Efficacy & Safety of Resatorvid in Adults With Severe Sepsis
- Efficacy and Safety of Resatorvid in Patients With Sepsis-induced Cardiovascular and Respiratory Failure
- [JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)](https://trialight.com/data/trial/just-breathe-breathing-life-into-innovative-therapies-for-b9153690-ceb2-4470-888a-92b70ddd73e7.md)
- JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart
- Mechanisms of Pain Hypersensitivity in a Human Skin Inflammation Model
- Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
- Study of a Combination of GSK1795091 and Immunotherapies in Subjects With Advanced Solid Tumors
- Study of an Anti-TLR4 mAb in Rheumatoid Arthritis
- TAK-242 in Patients With Acute Alcoholic Hepatitis
- The Effect of TLR4 Inhibition in Obese and Type 2 Diabetic Subjects
- The Role of TLR4 on Lipid-induced Insulin Resistance

### Drugs (5)

- Eritoran Toll-like receptor 4/MD-2 antagonist
- Eritoran tetrasodium Toll-like receptor 4/MD-2 antagonist
- GSK-1795091
- [Paridiprubart](https://trialight.com/data/asset/paridiprubart-58fc10af-7812-4b60-a9fa-9a3cd77868d1.md)
- Resatorvid Toll-like receptor 4 inhibitor

---

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