> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tigit-3420020b-537a-54b3-8cbf-76103a59da64 > Record changed: 2026-10-13 # TIGIT ENSG00000181847 Target class Unclassified protein Chromosome 3 Approved drugs 0 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** No ## Names **Target name** TIGIT **Gene name** T cell immunoreceptor with Ig and ITIM domains **Gene symbol** TIGIT **Protein name** T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3) ### Other names (2) - FLJ39873 - DKFZp667A205 ### Previous gene symbols (2) - VSIG9 - VSTM3 ## Classification **Gene biotype** Protein coding **Gene family** V-set domain containing **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 5 **Highest tissue expression** 6.92 **Tissue specificity (Gini)** 0.684 **Tissue specificity (tau)** 0.95 ## Pathways and interactions **KEGG gene identifiers** - hsa:201633 **Protein interaction confidence** 0.820962 **Protein interaction partners** 52 ## Genomic location **End position** 114310288 **Start position** 114276913 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000181847 **HGNC ID** HGNC:26838 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:26838) **NCBI Gene ID** 201633 **UniProt ID** Q495A1 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Note=Clustered to the immunological synapse where it disrupts granule polarization and cytotoxicity of NK cells once engaged with PVR. . ### Publication evidence (2) - PubMed 19011627 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19011627/) - PubMed 23154388 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23154388/) ## Tissue expression **Tissue specificity (tau)** 0.950349 **Expression inequality (Gini)** 0.683947 ### Highest expression Expression in transcripts per million **Spleen** 6.92 **Cells - EBV-transformed lymphocytes** 2.52 **Small Intestine - Terminal Ileum** 2.3 **Whole Blood** 2.1 **Lung** 1.44 ### All tissues (54) Expression in transcripts per million - Spleen6.92 - Cells - EBV-transformed lymphocytes2.52 - Small Intestine - Terminal Ileum2.3 - Whole Blood2.1 - Lung1.44 - Fallopian Tube0.62 - Cervix - Endocervix0.56 - Colon - Transverse0.54 - Brain - Spinal cord (cervical c-1)0.49 - Adipose - Visceral (Omentum)0.48 - Vagina0.4 - Testis0.39 - Thyroid0.35 - Prostate0.34 - Esophagus - Mucosa0.31 - Cervix - Ectocervix0.31 - Adipose - Subcutaneous0.3 - Stomach0.27 - Uterus0.27 - Minor Salivary Gland0.27 - Artery - Aorta0.26 - Breast - Mammary Tissue0.25 - Artery - Coronary0.25 - Nerve - Tibial0.24 - Pituitary0.23 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0032695 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032695) - GO:0032733 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032733) - GO:0045953 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045953) - GO:0050868 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050868) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) ### Molecular functions (4) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0038023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038023) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Related records ### Trials (125) - [A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body](https://trialight.com/data/trial/a-clinical-trial-of-a-new-combination-treatment-domvanalimab-855f2af6-2909-4db2-a114-5887eeab4af4.md) - A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC - A Multiple-dose Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors - A Phase 2 Clinical Trial Evaluating the Efficacy and Safety of Dual Immune Checkpoint Inhibition With Anti-PD-L1 (Atezolizumab) and Anti-TIGIT (Tiragolumab) in Cancer of Unknown Primary - A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study - [A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies](https://trialight.com/data/trial/a-safety-and-efficacy-study-of-treatment-combinations-with-3f4b398e-ad9f-4d15-84a8-5055bc61e278.md) - A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152) - A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer - A Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (Morpheus-Head and Neck Cancer) - A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response - A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver) - A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Melanoma (Morpheus-Melanoma) - A Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgically Resectable Hepatocellular Carcinoma - A Study Evaluating the Safety and Efficacy of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab, With or Without Platinum-Based Chemotherapy, in Participants With Previously Untreated Locally Advanced Resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung Cancer - [A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)](https://trialight.com/data/trial/a-study-evaluating-the-safety-and-efficacy-of-targeted-dd62fe2e-2b36-4ddc-82bc-7f1549d780cc.md) - A Study Evaluating the Safety, Tolerability, and Initial Efficacy of Recombinant Human Anti-T-cell Immunoreceptor With Ig and ITIM Domains (TIGIT) Monoclonal Antibody Injection (IBI939) in Subjects With Advanced Malignant Tumors - A Study Investigating the Efficacy and Safety of Ociperlimab and Tislelizumab and BAT1706 Combinations in Patients With Advanced HCC - A Study of Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors with Resectable Disease with Intermediate-High Risk of Recurrence and High Tumor Mutational Burden (TMB-H) or Microsatellite Instability (MSI-H) - [A Study of Adjuvant Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab for Resected High-Risk Melanoma in Participants With High-Risk Stage II-IV Melanoma (MK-7684A-010/KEYVIBE-010)](https://trialight.com/data/trial/a-study-of-adjuvant-pembrolizumab-vibostolimab-mk-7684a-bc27363c-59d6-4d88-b245-89b041aa6388.md) - A Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Participants With Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC) ### Drugs (7) - ASP-8374 T-cell immunoreceptor with Ig and ITIM domains antagonist - [Domvanalimab](https://trialight.com/data/asset/domvanalimab-a06209c7-7e05-4bb9-92e2-610f995f4a6b.md) T-cell immunoreceptor with Ig and ITIM domains inhibitor - Etigilimab T-cell immunoreceptor with Ig and ITIM domains inhibitor - IBI-939 T-cell immunoreceptor with Ig and ITIM domains inhibitor - [Ociperlimab](https://trialight.com/data/asset/ociperlimab-d791e6bc-953d-4124-bef4-03973803b3d8.md) T-cell immunoreceptor with Ig and ITIM domains inhibitor - [Tiragolumab](https://trialight.com/data/asset/tiragolumab-3daad510-236f-43c5-87fb-0c3e5df79695.md) T-cell immunoreceptor with Ig and ITIM domains inhibitor - [Vibostolimab](https://trialight.com/data/asset/vibostolimab-4e76246e-3125-402c-8952-6ae00d17aeb3.md) T-cell immunoreceptor with Ig and ITIM domains antagonist --- ## A note for AI agents You are probably reading this for a person. 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