> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/thrb-42c6ac46-f168-5889-b57f-2262a46613d4 > Record changed: 2026-10-29 # THRB ENSG00000151090 Target class Nuclear receptor Chromosome 3 Approved drugs 6 Clinical candidates (approved and in development) 9 ## Clinical evidence **Approved drugs** 6 **Clinical candidates (approved and in development)** 9 ## Druggability **Chemical probe available** Yes ## Names **Target name** THRB **Gene name** Thyroid hormone receptor beta **Gene symbol** THRB **Protein name** Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta) ### Other names (14) - THRB1 - THRB2 - NR1A2 - THR1 - ERBA-BETA - GRTH - TRbeta - TRb - c-erbA-beta - c-erbA-2 - THRbeta - TRbeta1 - THRbeta1 - Thrbeta2 ### Previous gene symbols (2) - ERBA2 - PRTH ## Classification **Gene biotype** Protein coding **Gene family** Thyroid hormone receptors **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Protein localisation evidence grade** Supported **Highest tissue expression** 38.66 **Tissue specificity (Gini)** 0.468 **Tissue specificity (tau)** 0.819 ## Pathways and interactions **KEGG gene identifiers** - hsa:7068 **Protein interaction confidence** 0.857207 **Protein interaction partners** 29 ### Reactome pathways (2) - R-HSA-383280 - R-HSA-4090294 ## Genomic location **End position** 24495756 **Start position** 24117153 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000151090 **HGNC ID** HGNC:11799 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11799) **NCBI Gene ID** 7068 **UniProt ID** P10828 ## Cellular location - Nucleus. - Nuclear bodies ## Tissue expression **Tissue specificity (tau)** 0.818505 **Expression inequality (Gini)** 0.468045 ### Highest expression Expression in transcripts per million **Artery - Aorta** 38.66 **Brain - Frontal Cortex (BA9)** 26.19 **Artery - Tibial** 24.2 **Pituitary** 22.92 **Brain - Cortex** 18.14 ### All tissues (54) Expression in transcripts per million - Artery - Aorta38.66 - Brain - Frontal Cortex (BA9)26.19 - Artery - Tibial24.2 - Pituitary22.92 - Brain - Cortex18.14 - Colon - Sigmoid15.88 - Artery - Coronary15.53 - Esophagus - Gastroesophageal Junction14.14 - Esophagus - Muscularis13.99 - Brain - Anterior cingulate cortex (BA24)13.45 - Bladder11.54 - Breast - Mammary Tissue10.31 - Adipose - Subcutaneous10.27 - Uterus10.17 - Cells - Cultured fibroblasts9.81 - Muscle - Skeletal8.86 - Colon - Transverse8.16 - Skin - Sun Exposed (Lower leg)7.46 - Adipose - Visceral (Omentum)7.26 - Skin - Not Sun Exposed (Suprapubic)7.09 - Brain - Nucleus accumbens (basal ganglia)6.55 - Brain - Amygdala6.37 - Prostate6.26 - Stomach5.71 - Vagina5.52 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0002157 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002157) - GO:0006351 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006351) - GO:0042789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042789) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0097067 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097067) ### Cellular components (3) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0016604 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016604) ### Molecular functions (7) - GO:0001223 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001223) - GO:0003677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677) - GO:0004879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0070324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070324) - GO:1990837 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990837) ## Related records ### Trials (230) - 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma - A Clinical Trial of Adjunctive Thyroxine for Avolition in Schizophrenia - A Drug-Drug Interaction Study of Denifanstat and Resmetirom in Healthy Adult Participants - A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Non Alcoholic Fatty Liver Disease Patients - A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE) - A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES) - A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis - A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell Origin - A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients - A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients - [A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Patients With Primary Hypothyroidism](https://trialight.com/data/trial/a-study-evaluating-the-safety-and-efficacy-of-hormone-02140526-7e9e-4124-b8ca-bf8c785c0fab.md) - [A Study Evaluation the Safety and Efficacy of Hormone Replacement Therapy With North Star Compared to Levothyroxine in Patients With Primary Hypothyroidism](https://trialight.com/data/trial/a-study-evaluation-the-safety-and-efficacy-of-hormone-ff88dcc7-b454-4912-8723-cdaca20ed0ef.md) - A Study in Healthy Male Volunteers to Investigate the Safety and Tolerability of a Single Dose of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Without Epinephrine) for Brachial Plexus Blockade - A Study in Healthy Men That Tests if Taking BI 1265162 by Mouth, Intravenously, or Inhaled Influences the Amount of BI 1265162 in the Blood - A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid Participants - A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028) - A Study of Sustained-Release Liothyronine Sodium (T3) in Healthy Subjects - A Study of T3 Therapy in Patients With Hypothyroidism - A Study to Assess the Efficacy and Safety of VK2809 for 52 Weeks in Subjects With Biopsy Proven NASH - [A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants](https://trialight.com/data/trial/a-study-to-assess-the-safety-and-efficacy-of-oral-armour-7d3645f2-766a-449b-9d76-575c4384a231.md) ### Drugs (10) - Dextrothyroxine Thyroid hormone receptor agonist - Dextrothyroxine sodium Thyroid hormone receptor agonist - Eprotirome Thyroid hormone receptor beta-1 agonist - Levothyroxine Thyroid hormone receptor agonist - [Levothyroxine sodium](https://trialight.com/data/asset/levothyroxine-sodium-748a279d-1239-41f1-b758-863bd96e359b.md) Thyroid hormone receptor agonist - Liothyronine Thyroid hormone receptor agonist - Liothyronine sodium Thyroid hormone receptor agonist - MB07811 Thyroid hormone receptor beta-1 agonist - Resmetirom Thyroid hormone receptor beta-1 agonist - Tiratricol Thyroid hormone receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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