> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/thra-794e5b29-0985-5208-bfb5-40a8ff0430b7 > Record changed: 2026-10-13 # THRA ENSG00000126351 Target class Nuclear receptor Chromosome 17 Approved drugs 5 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Target name** THRA **Gene name** Thyroid hormone receptor alpha **Gene symbol** THRA **Protein name** Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha) ### Other names (13) - EAR-7.1/EAR-7.2 - THRA3 - AR7 - ERBA - NR1A1 - TRalpha - TRalpha1 - TRalpha2 - c-ERBA-1 - c-erbA - THRalpha - THRalpha1 - THRalpha2 ### Previous gene symbols (3) - THRA1 - THRA2 - ERBA1 ## Classification **Gene biotype** Protein coding **Gene family** Thyroid hormone receptors **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 172.85 **Tissue specificity (Gini)** 0.371 **Tissue specificity (tau)** 0.715 ## Pathways and interactions **KEGG gene identifiers** - hsa:7067 **Reactome pathways** - R-HSA-383280 **Protein interaction confidence** 0.870793 **Protein interaction partners** 29 ## Genomic location **End position** 40093867 **Start position** 40058290 **Chromosome** 17 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000126351 **HGNC ID** HGNC:11796 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11796) **NCBI Gene ID** 7067 **UniProt ID** P10827 ## Cellular location - Nucleus. - SUBCELLULAR LOCATION: \[Isoform Alpha-2\]: Cytoplasm . Nucleus . Note=When overexpressed found in the cytoplasm where it colocalizes with TACC1\. . ## Tissue expression **Tissue specificity (tau)** 0.715442 **Expression inequality (Gini)** 0.371082 ### Highest expression Expression in transcripts per million **Brain - Nucleus accumbens (basal ganglia)** 172.85 **Brain - Cerebellar Hemisphere** 144.48 **Brain - Cerebellum** 126.29 **Brain - Caudate (basal ganglia)** 110.37 **Brain - Anterior cingulate cortex (BA24)** 109.66 ### All tissues (54) Expression in transcripts per million - Brain - Nucleus accumbens (basal ganglia)172.85 - Brain - Cerebellar Hemisphere144.48 - Brain - Cerebellum126.29 - Brain - Caudate (basal ganglia)110.37 - Brain - Anterior cingulate cortex (BA24)109.66 - Brain - Frontal Cortex (BA9)103.82 - Brain - Cortex94.77 - Brain - Amygdala92.99 - Brain - Hypothalamus78.25 - Brain - Putamen (basal ganglia)74.6 - Artery - Tibial72.67 - Cervix - Ectocervix71.27 - Ovary68.53 - Brain - Hippocampus67.53 - Colon - Sigmoid65.76 - Cervix - Endocervix65.73 - Brain - Spinal cord (cervical c-1)65.36 - Uterus65.17 - Brain - Substantia nigra58.58 - Fallopian Tube57.7 - Artery - Aorta55.18 - Esophagus - Gastroesophageal Junction53.28 - Nerve - Tibial53.1 - Esophagus - Muscularis50.54 - Artery - Coronary48.58 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0006357 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006357) - GO:0006366 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006366) - GO:0009755 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009755) - GO:0017055 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017055) - GO:0045892 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045892) - GO:2000143 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000143) ### Cellular components (3) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (8) - GO:0000976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000976) - GO:0003700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003700) - GO:0004879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0017025 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017025) - GO:0019904 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019904) - GO:0070324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070324) - GO:0140296 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140296) ## Off-target safety - receptor binding ### Studies - biochemical: NVS\_NR\_hTRa\_Antagonist, is one of one assay component(s) measured or calculated from the NVS\_NR\_hTRa\_Antagonist assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with chemiluminescence signals by AlphaLISA immunoassay technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of transcription factor activity ### Studies (2) - cell-based: ATG\_THRa1\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_THRa1\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. ### Biological samples - HepG2, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (200) - 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma - A Clinical Trial of Adjunctive Thyroxine for Avolition in Schizophrenia - A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell Origin - A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients - A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients - [A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Patients With Primary Hypothyroidism](https://trialight.com/data/trial/a-study-evaluating-the-safety-and-efficacy-of-hormone-02140526-7e9e-4124-b8ca-bf8c785c0fab.md) - [A Study Evaluation the Safety and Efficacy of Hormone Replacement Therapy With North Star Compared to Levothyroxine in Patients With Primary Hypothyroidism](https://trialight.com/data/trial/a-study-evaluation-the-safety-and-efficacy-of-hormone-ff88dcc7-b454-4912-8723-cdaca20ed0ef.md) - A Study in Healthy Male Volunteers to Investigate the Safety and Tolerability of a Single Dose of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Without Epinephrine) for Brachial Plexus Blockade - A Study in Healthy Men That Tests if Taking BI 1265162 by Mouth, Intravenously, or Inhaled Influences the Amount of BI 1265162 in the Blood - A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid Participants - A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028) - A Study of Sustained-Release Liothyronine Sodium (T3) in Healthy Subjects - A Study of T3 Therapy in Patients With Hypothyroidism - [A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants](https://trialight.com/data/trial/a-study-to-assess-the-safety-and-efficacy-of-oral-armour-7d3645f2-766a-449b-9d76-575c4384a231.md) - A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Levothyroxine and the Influence of Co-administered Tablets on the Pharmacokinetics of Semaglutide Administered Orally in Healthy Subjects. - Acceleration and Relapse Prevention With Triiodothyronine (T3) as an Adjunct to Electroconvulsive Therapy (ECT) - Antithyroid Drug Treatment of Thyrotoxicosis in Young People - Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T3)and Reboxetine: Clinical Efficacy, Adverse Effects and Predictors of Response. - Azacitidine to Restore Thyroid Function in Patients With Persistent or Metastatic Thyroid Cancer - BE of Euthyrox® Tablets (Merck Nantong Versus Merck Darmstadt Sites) ### Drugs (7) - Dextrothyroxine Thyroid hormone receptor agonist - Dextrothyroxine sodium Thyroid hormone receptor agonist - Levothyroxine Thyroid hormone receptor agonist - [Levothyroxine sodium](https://trialight.com/data/asset/levothyroxine-sodium-748a279d-1239-41f1-b758-863bd96e359b.md) Thyroid hormone receptor agonist - Liothyronine Thyroid hormone receptor agonist - Liothyronine sodium Thyroid hormone receptor agonist - Tiratricol Thyroid hormone receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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