THRA

ENSG00000126351
Target class
Nuclear receptor
Chromosome
17
Approved drugs
5
Clinical candidates (approved and in development)
6

Approved drugs
5
Clinical candidates (approved and in development)
6

Chemical probe available
No

Target name
THRA
Gene name
Thyroid hormone receptor alpha
Gene symbol
THRA
Protein name
Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)

  • EAR-7.1/EAR-7.2
  • THRA3
  • AR7
  • ERBA
  • NR1A1
  • TRalpha
  • TRalpha1
  • TRalpha2
  • c-ERBA-1
  • c-erbA
  • THRalpha
  • THRalpha1
  • THRalpha2

  • THRA1
  • THRA2
  • ERBA1

Gene biotype
Protein coding
Gene family
Thyroid hormone receptors
Target class
Nuclear receptor
Target type
Human gene

Tissues expressed in
54
Protein localisation evidence grade
Uncertain
Highest tissue expression
172.85
Tissue specificity (Gini)
0.371
Tissue specificity (tau)
0.715

KEGG gene identifiers
  • hsa:7067
Reactome pathways
  • R-HSA-383280
Protein interaction confidence
0.870793
Protein interaction partners
29

End position
40093867
Start position
40058290
Chromosome
17
Strand
Forward

Ensembl gene ID
ENSG00000126351
HGNC ID
HGNC:11796
www.genenames.org
NCBI Gene ID
7067
UniProt ID
P10827

  • Nucleus.
  • SUBCELLULAR LOCATION: [Isoform Alpha-2]: Cytoplasm . Nucleus . Note=When overexpressed found in the cytoplasm where it colocalizes with TACC1. .

Tissue specificity (tau)
0.715442
Expression inequality (Gini)
0.371082

Expression in transcripts per million

Brain - Nucleus accumbens (basal ganglia)
172.85
Brain - Cerebellar Hemisphere
144.48
Brain - Cerebellum
126.29
Brain - Caudate (basal ganglia)
110.37
Brain - Anterior cingulate cortex (BA24)
109.66

Expression in transcripts per million

  • Brain - Nucleus accumbens (basal ganglia)172.85
  • Brain - Cerebellar Hemisphere144.48
  • Brain - Cerebellum126.29
  • Brain - Caudate (basal ganglia)110.37
  • Brain - Anterior cingulate cortex (BA24)109.66
  • Brain - Frontal Cortex (BA9)103.82
  • Brain - Cortex94.77
  • Brain - Amygdala92.99
  • Brain - Hypothalamus78.25
  • Brain - Putamen (basal ganglia)74.6
  • Artery - Tibial72.67
  • Cervix - Ectocervix71.27
  • Ovary68.53
  • Brain - Hippocampus67.53
  • Colon - Sigmoid65.76
  • Cervix - Endocervix65.73
  • Brain - Spinal cord (cervical c-1)65.36
  • Uterus65.17
  • Brain - Substantia nigra58.58
  • Fallopian Tube57.7
  • Artery - Aorta55.18
  • Esophagus - Gastroesophageal Junction53.28
  • Nerve - Tibial53.1
  • Esophagus - Muscularis50.54
  • Artery - Coronary48.58

And 29 more, listed on the interactive page.

  • receptor binding

    Studies

    • biochemical: NVS_NR_hTRa_Antagonist, is one of one assay component(s) measured or calculated from the NVS_NR_hTRa_Antagonist assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with chemiluminescence signals by AlphaLISA immunoassay technology.

    Biological samples

    • cell-free
    Evidence source
    www.epa.gov

  • regulation of transcription factor activity

    • cell-based: ATG_THRa1_TRANS, is one of 30 assay component(s) measured or calculated from the ATG_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.
    • cell-based: ATG_THRa1_TRANS, is one of 30 assay component(s) measured or calculated from the ATG_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.

    Biological samples

    • HepG2, cell line
    Evidence source
    www.epa.gov

Related records

Trials (200)

Drugs (7)