> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tfpi-55e91512-a0e1-54c9-8447-c36bc030ef73 > Record changed: 2026-10-13 # TFPI ENSG00000003436 Target class Unclassified protein Chromosome 2 Approved drugs 3 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** No ## Names **Target name** TFPI **Gene name** Tissue factor pathway inhibitor **Gene symbol** TFPI **Previous gene symbols** - LACI **Protein name** Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) ### Other names (3) - EPI - TFI - TFPI1 ## Classification **Gene biotype** Protein coding **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 43 **Highest tissue expression** 126.79 **Tissue specificity (Gini)** 0.542 **Tissue specificity (tau)** 0.843 ## Pathways and interactions **KEGG gene identifiers** - hsa:7035 **Protein interaction confidence** 0.816542 **Protein interaction partners** 24 ## Genomic location **End position** 187565846 **Start position** 187463823 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000003436 **HGNC ID** HGNC:11760 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11760) **NCBI Gene ID** 7035 **UniProt ID** P10646 ## Cellular location - \[Isoform Alpha\]: Secreted. - SUBCELLULAR LOCATION: \[Isoform Beta\]: Microsome membrane - Lipid-anchor, GPI-anchor . ### Publication evidence - PubMed 22144186 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22144186/) ## Tissue expression **Tissue specificity (tau)** 0.84344 **Expression inequality (Gini)** 0.54167 ### Highest expression Expression in transcripts per million **Lung** 126.79 **Cells - Cultured fibroblasts** 77.24 **Liver** 58.72 **Artery - Coronary** 54.13 **Adipose - Subcutaneous** 52.98 ### All tissues (54) Expression in transcripts per million - Lung126.79 - Cells - Cultured fibroblasts77.24 - Liver58.72 - Artery - Coronary54.13 - Adipose - Subcutaneous52.98 - Adipose - Visceral (Omentum)45.04 - Breast - Mammary Tissue44.68 - Fallopian Tube43.23 - Thyroid42.01 - Nerve - Tibial41.94 - Cervix - Ectocervix41.62 - Cervix - Endocervix39.39 - Artery - Tibial37.84 - Bladder33.33 - Esophagus - Gastroesophageal Junction32.16 - Vagina30.92 - Small Intestine - Terminal Ileum29.7 - Uterus29.69 - Artery - Aorta29.19 - Esophagus - Muscularis26.59 - Kidney - Medulla23.12 - Ovary21.06 - Colon - Sigmoid19.35 - Spleen17.61 - Kidney - Cortex17.54 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596) - GO:0030195 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030195) - GO:0071383 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071383) ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005901) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) ### Molecular functions - GO:0004866 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004866) ## Related records ### Trials (44) - A Clinical Trial of Study Medicine (Marstacimab) in Pediatric Patients With Hemophilia A or Hemophilia B - A Healthy Volunteer Pharmacokinetics (PK)/Pharmacodynamics (PD), Safety and Tolerability Study of Andexanet in Healthy Japanese and Caucasian Subjects - A Healthy Volunteer PK/PD, Safety and Tolerability Study of Andexanet After Betrixaban Dosing - A Healthy Volunteer PK/PD, Safety and Tolerability Study of Second Generation Andexanet Alfa - A Multi-centre, Open Labelled, Multiple Dosing Trial Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC 0172-2021 Administered Subcutaneously to Healthy Male Subjects and Haemophilia Subjects - A Research Study on How Well Concizumab Works for You if You Have Haemophilia A or B With or Without Inhibitors - A Single Escalating Dose and Multiple Dose Study of BAY 1093884 in Subjects With Severe Hemophilia Types A or B, With or Without Inhibitors - A Study of Andexanet Alfa in Patients Requiring Urgent Surgery or Procedure - A Study of Marstacimab to Compare Prefilled Pen (PFP) Device to Prefilled Syringe (PFS) Device - A Study to Assess Pharmacokinetics and Pharmacodynamics Following Administration of BAY1093884 in Patients With Severe Hemophilia - [A Study to Investigate Andexanet Dosing and the Interaction Between Andexanet and Subsequent Enoxaparin in Healthy Participants](https://trialight.com/data/trial/a-study-to-investigate-andexanet-dosing-and-the-interaction-987fbcda-b695-4322-aeba-d98d15849af7.md) - A Study to Learn About How Changing Therapy From Emicizumab to Marstacimab Affects People With the Severe Hemophilia A. - A Study to Learn About the Study Medicine -Hympavzi in Congenital Hemophilia Patients Without Inhibitors in Japan. - A Trial Evaluating Efficacy and Safety of Prophylactic Administration of Concizumab in Patients With Severe Haemophilia A Without Inhibitors - A Trial Evaluating the Efficacy and Safety of Prophylactic Administration of Concizumab in Haemophilia A and B Patients With Inhibitors - Adult and Adolescent Hemophilia Patients Treated With Marstacimab: a Patient Experience Registry - Andexanet Alfa and 4F-PCC Use in Patients Hospitalised With an Anticoagulant-related Major Bleed - Compassionate Use of Concizumab if You Have Haemophilia - Dose Escalation Study of PF-06741086 In Healthy Subjects - Investigation of the Pharmacokinetics of NNC172-2021, at Two Different Dose Levels, in Healthy Japanese Subjects ### Drugs (4) - [Andexanet alfa](https://trialight.com/data/asset/andexanet-alfa-9caba2c5-7b01-4a0f-a459-eebd0f65650a.md) Tissue factor pathway inhibitor inhibitor - BAY-1093884 Tissue factor pathway inhibitor inhibitor - Concizumab Tissue factor pathway inhibitor inhibitor - Marstacimab Tissue factor pathway inhibitor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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