> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tek-8c4a1834-7f6d-5bd8-856d-23e03f1ae791 > Record changed: 2026-10-13 # TEK ENSG00000120156 Target class Kinase Chromosome 9 Approved drugs 2 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 2 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** Yes ## Names **Target name** TEK **Gene name** TEK receptor tyrosine kinase **Gene symbol** TEK **Previous gene symbols** - VMCM **Protein name** Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) ### Other names (4) - TIE2 - TIE-2 - VMCM1 - CD202b ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|CD molecules|Fibronectin type III domain containing|Immunoglobulin like domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Protein localisation evidence grade** Supported **Highest tissue expression** 50.74 **Tissue specificity (Gini)** 0.426 **Tissue specificity (tau)** 0.828 ## Pathways and interactions **KEGG gene identifiers** - hsa:7010 **Protein interaction confidence** 0.815547 **Protein interaction partners** 75 ### Reactome pathways (2) - R-HSA-210993 - R-HSA-5673001 ## Genomic location **End position** 27232092 **Start position** 27109030 **Chromosome** 9 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000120156 **HGNC ID** HGNC:11724 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11724) **NCBI Gene ID** 7010 **UniProt ID** Q02763 ## Cellular location - Cell membrane - Single-pass type I membrane protein. Cell junction . Cell junction, focal adhesion . Cytoplasm, cytoskeleton. Secreted . Note=Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425119, PubMed:18425120). Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244). . - Plasma membrane ### Publication evidence (6) - PubMed 18425119 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18425119/) - PubMed 18425120 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18425120/) - PubMed 19079259 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19079259/) - PubMed 27270174 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27270174/) - PubMed 19293632 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19293632/) - PubMed 11806244 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11806244/) ## Tissue expression **Tissue specificity (tau)** 0.827798 **Expression inequality (Gini)** 0.425689 ### Highest expression Expression in transcripts per million **Lung** 50.74 **Adipose - Subcutaneous** 32.65 **Adipose - Visceral (Omentum)** 26.35 **Breast - Mammary Tissue** 23.38 **Thyroid** 21.75 ### All tissues (54) Expression in transcripts per million - Lung50.74 - Adipose - Subcutaneous32.65 - Adipose - Visceral (Omentum)26.35 - Breast - Mammary Tissue23.38 - Thyroid21.75 - Spleen19.54 - Kidney - Medulla17.8 - Uterus17.65 - Artery - Coronary15.96 - Nerve - Tibial14.25 - Fallopian Tube12.81 - Cervix - Endocervix12.69 - Kidney - Cortex11.36 - Artery - Tibial10.62 - Cervix - Ectocervix10.55 - Esophagus - Gastroesophageal Junction10.3 - Esophagus - Muscularis10.09 - Adrenal Gland9.95 - Heart - Atrial Appendage9.63 - Artery - Aorta9.56 - Heart - Left Ventricle9.36 - Small Intestine - Terminal Ileum8.49 - Colon - Sigmoid8.48 - Bladder8.17 - Vagina7.16 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (25) - GO:0001525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001525) - GO:0001938 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001938) - GO:0002040 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002040) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007169) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0010595 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010595) - GO:0016525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016525) - GO:0032878 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032878) - GO:0034446 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034446) - GO:0035022 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035022) - GO:0035025 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035025) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0043114 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043114) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0045766 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045766) - GO:0048014 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048014) - GO:0050728 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050728) - GO:0051894 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051894) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0060216 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060216) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) - GO:0071260 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071260) - GO:1902533 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902533) - GO:2000351 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000351) ### Cellular components (12) - GO:0001725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001725) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005884 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005884) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005902 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005902) - GO:0005911 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005911) - GO:0009925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009925) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0016323 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) - GO:0070161 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070161) ### Molecular functions (7) - GO:0004672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019199 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019199) - GO:0038023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038023) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hTie2, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hTie2 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (555) - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST - \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib - \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial - \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation - 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) - 18F-DCFBC PET/CT in Prostate Cancer - 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer - 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer - 68Ga-NODAGA-RGD PET/ CT for Tumoral Neoangiogenesis - 68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC. - 68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC - 68Ga-PSMA PET/CT in Prostate Cancer - 68Ga-PSMA PET/CT in Prostate Cancer - 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Intermediate Risk Prostate Cancer Imaging - 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Prostate Cancer Imaging According to Various Metastatic Risks - 89Zr-TLX250 for PET/CT Imaging of ccRCC - ZIRCON-CP Study ### Drugs (8) - Altiratinib Tyrosine-protein kinase TIE-2 inhibitor - CE-245677 Tyrosine-protein kinase TIE-2 inhibitor - [CEP-11981](https://trialight.com/data/asset/cep-11981-b221c5f0-2453-4f9c-b8b4-15a86c81e937.md) Tyrosine-protein kinase TIE-2 inhibitor - Foretinib Tyrosine-protein kinase TIE-2 inhibitor - Glesatinib Tyrosine-protein kinase TIE-2 inhibitor - Pexmetinib Tyrosine-protein kinase TIE-2 inhibitor - [Regorafenib](https://trialight.com/data/asset/regorafenib-333c1c36-b89a-41d5-b39e-bcec7346fe94.md) Tyrosine-protein kinase TIE-2 inhibitor - Vandetanib Tyrosine-protein kinase TIE-2 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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