> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tas2r38-5be7eff8-5b77-5066-9863-c65c963d960e > Record changed: 2026-11-04 # TAS2R38 ENSG00000257138 Target class GPCR Chromosome 7 ## Druggability **Chemical probe available** No ## Names **Other names** - T2R61 **Target name** TAS2R38 **Gene name** Taste 2 receptor member 38 **Gene symbol** TAS2R38 **Previous gene symbols** - PTC **Protein name** Taste receptor type 2 member 38 (T2R38) (PTC bitter taste receptor) (Taste receptor type 2 member 61) (T2R61) ## Classification **Gene biotype** Protein coding **Gene family** Taste 2 receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 0 **Highest tissue expression** 0.16 **Tissue specificity (Gini)** 0.955 **Tissue specificity (tau)** 0.982 ## Pathways and interactions **KEGG gene identifiers** - hsa:5726 **Protein interaction confidence** 0.882429 **Protein interaction partners** 7 ### Reactome pathways (3) - R-HSA-418594 - R-HSA-420499 - R-HSA-9717207 ## Genomic location **End position** 141973773 **Start position** 141972631 **Chromosome** 7 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000257138 **HGNC ID** HGNC:9584 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9584) **NCBI Gene ID** 5726 **UniProt ID** P59533 ## Cellular location - Membrane - Multi-pass membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.982311 **Expression inequality (Gini)** 0.955197 ### Highest expression Expression in transcripts per million **Small Intestine - Terminal Ileum** 0.16 **Testis** 0.1 **Pancreas** 0.03 **Colon - Transverse** 0.02 **Artery - Aorta** 0 ### All tissues (54) Expression in transcripts per million - Small Intestine - Terminal Ileum0.16 - Testis0.1 - Pancreas0.03 - Colon - Transverse0.02 - Artery - Aorta0 - Cervix - Ectocervix0 - Lung0 - Breast - Mammary Tissue0 - Brain - Anterior cingulate cortex (BA24)0 - Brain - Nucleus accumbens (basal ganglia)0 - Skin - Not Sun Exposed (Suprapubic)0 - Adrenal Gland0 - Brain - Frontal Cortex (BA9)0 - Colon - Sigmoid0 - Ovary0 - Cells - EBV-transformed lymphocytes0 - Cervix - Endocervix0 - Brain - Substantia nigra0 - Brain - Amygdala0 - Nerve - Tibial0 - Esophagus - Mucosa0 - Fallopian Tube0 - Brain - Hippocampus0 - Cells - Cultured fibroblasts0 - Minor Salivary Gland0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0001580 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001580) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions - GO:0033038 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033038) ## Related records ### Trials (98) - 10-Propargyl-10-Deazaaminopterin Plus Probenecid in Treating Patients With Advanced Solid Tumors - A Clinical Follow-up Study on Drug Therapy for Graves' Disease Patients in China - A Clinical Study of Hyperthyroidism in Children - A Clinical Study of MK-8527 in Healthy Participants (MK-8527-021) - A Conservative vs an Ablative Approach for Treatment of Hyperthyroidism in Patients With Graves' Orbitopathy - A Drug Interaction Study of VI-0521 With Metformin, Sitagliptan and Probenecid in Healthy Subjects. - A Phase 1 Study to Evaluate the Effect of the Organic Anion Transporter Inhibitor Probenecid on the Pharmacokinetics of JNJ-64041575 in Healthy Adults - A Relative Bioavailability Study With a Novel PanCytoVir™ Oral Suspension (100 mg/ml) - A Study in Healthy People to Test How 2 Different Formulations of BI 690517 Are Taken up in the Body and How Probenecid Influences the Amount of BI 690517 in the Blood - A Study of Baricitinib and Probenecid in Healthy Participants - A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease - A Study to Assess Pharmacokinetics of PF-04965842 and Its Metabolites and Effect of Probenecid in Healthy Participants - A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics and the Effect of Probenecid on Povorcitinib Pharmacokinetics When Administered Orally to Healthy Adult Participants - A Study to Assess the Effects of Multiple-Dose Probenecid on the Multiple-Dose Pharmacokinetics of Canagliflozin in Healthy Volunteers - A Study to Assess the Effects of Probenecid on the Pharmacokinetics of Mirdametinib and Its Metabolites in Healthy Participants - A Study to Evaluate the Drug-drug Interactions (DDIs) of DBPR108 With Warfarin Sodium, Digoxin, Probenecid in Healthy Subjects - A Study to Evaluate the Efficacy of PanCytoVir™ for the Treatment of Non-Hospitalized Patients With COVID-19 Infection - A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients - A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060 - A Trial Investigating the Effect of Probenecid and Ciclosporin on the Concentrations of SNAC in Healthy Subjects ### Drugs (3) - Methimazole - [Probenecid](https://trialight.com/data/asset/probenecid-0864a3cb-3764-4994-8995-3400af689d1e.md) - Propylthiouracil --- ## A note for AI agents You are probably reading this for a person. 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