> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tacstd2-dcd01535-775a-5186-8b63-b561f4a468af > Record changed: 2026-10-13 # TACSTD2 ENSG00000184292 Target class Unclassified protein Chromosome 1 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** TACSTD2 **Gene name** Tumor associated calcium signal transducer 2 **Gene symbol** TACSTD2 **Previous gene symbols** - M1S1 **Protein name** Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1) ### Other names (3) - TROP2 - GA733-1 - EGP-1 ## Classification **Gene biotype** Protein coding **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 36 **Protein localisation evidence grade** Supported **Highest tissue expression** 1,419.1 **Tissue specificity (Gini)** 0.876 **Tissue specificity (tau)** 0.952 ## Pathways and interactions **KEGG gene identifiers** - hsa:4070 **Protein interaction confidence** 0.809833 **Protein interaction partners** 6 ## Genomic location **End position** 58577252 **Start position** 58575433 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000184292 **HGNC ID** HGNC:11530 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11530) **NCBI Gene ID** 4070 **UniProt ID** P09758 ## Cellular location - Membrane - Single-pass type I membrane protein. - Nucleoli - Plasma membrane - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.952015 **Expression inequality (Gini)** 0.876374 ### Highest expression Expression in transcripts per million **Esophagus - Mucosa** 1,419.1 **Skin - Not Sun Exposed (Suprapubic)** 708.7 **Skin - Sun Exposed (Lower leg)** 683.92 **Minor Salivary Gland** 680.75 **Vagina** 655.98 ### All tissues (54) Expression in transcripts per million - Esophagus - Mucosa1,419.1 - Skin - Not Sun Exposed (Suprapubic)708.7 - Skin - Sun Exposed (Lower leg)683.92 - Minor Salivary Gland680.75 - Vagina655.98 - Kidney - Medulla218.48 - Prostate154.07 - Breast - Mammary Tissue131.47 - Lung118.69 - Kidney - Cortex59.22 - Pancreas46.47 - Bladder38.39 - Fallopian Tube18.22 - Nerve - Tibial11.65 - Stomach9.72 - Thyroid8.1 - Adipose - Subcutaneous6.28 - Artery - Aorta6.04 - Artery - Tibial5.06 - Cervix - Ectocervix5.05 - Uterus4.84 - Cervix - Endocervix4.15 - Artery - Coronary3.98 - Cells - Cultured fibroblasts2.93 - Adipose - Visceral (Omentum)2.23 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0007601 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007601) ### Cellular components (4) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (185) - A Multicenter, Prospective, Cohort Study of Trop-2 ADC Combination Therapy for Advanced Triple-negative Breast Cancer - A Multicenter, Prospective, Phase II Study of TROP-2 ADC in Combination With Toripalimab for Resectable Locally Advanced Oral Squamous Cell Carcinoma - A Phase I/II Study of Sacituzumab Govitecan Plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmonary Small Cell Neuroendocrine Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP Inhibitors - A Phase II Study of Neoadjuvant Sacituzumab Govitecan and Pembrolizumab Therapy for Immunochemotherapy-resistant Early-stage Triple-negative Breast Cancer (TNBC) - A Phase II Trial of Sacituzumab Govitecan in Patients With Advanced Thymic Epithelial Tumors - [A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer](https://trialight.com/data/trial/a-phase-iii-randomised-study-to-evaluate-dato-dxd-and-e686a63e-e154-4541-9257-c890ab5f83d0.md) - A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05) - A Phase III Study of JSKN016 Versus Treatment of Physician's Choice in Patients With Triple-Negative Breast Cancer Who Have Failed Standard of Care - A Phase III, Randomised Study of Adjuvant Dato-DXd in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Standard of Care, Following Complete Tumour Resection, in Participants With Stage I Adenocarcinoma NSCLC Who Are ctDNA-positive or Have High-risk Pathological Features - A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01) - A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer) - A Single-arm Phase II Trial of SAcituzumab Govitecan and Trastuzumab for HER2+ Metastatic Breast Cancer After Trastuzumab dEruxtEcaN (SATEEN) - A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer - A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer - [A Study of AZD3470, a PRMT5 Inhibitor, Given as Monotherapy and in Combination in Patients With MTAP Deficient Advanced/Metastatic Solid Tumors](https://trialight.com/data/trial/a-study-of-azd3470-a-prmt5-inhibitor-given-as-monotherapy-a149dcf4-f4d6-4334-a82f-2f92ad0af0eb.md) - [A Study of CLN-619 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors](https://trialight.com/data/trial/a-study-of-cln-619-alone-and-in-combination-with-ab3889da-c2fc-42ea-9116-1f8a95302189.md) - A Study of Dato-DXd in Chinese Patients With Advanced Non-Small Cell Lung Cancer, Triple-negative Breast Cancer and Other Solid Tumors (TROPION-PanTumor02) - A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer - A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02) - [A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)](https://trialight.com/data/trial/a-study-of-dato-dxd-with-or-without-durvalumab-versus-3cb6b909-4ecb-4ab6-8ea2-206cf5254fd4.md) ### Drugs (2) - [Datopotamab deruxtecan](https://trialight.com/data/asset/datopotamab-deruxtecan-7c3e1007-5db7-4633-bfdb-335de1c23f10.md) Tumor-associated calcium signal transducer 2 binding agent - [Sacituzumab govitecan](https://trialight.com/data/asset/sacituzumab-govitecan-fce40bcf-4086-4a36-a9b1-767dee19e0ba.md) Tumor-associated calcium signal transducer 2 binding agent --- ## A note for AI agents You are probably reading this for a person. 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