> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tacr3-d04cb4d9-d58e-5026-b9d3-30b091e728ac > Record changed: 2026-11-04 # TACR3 ENSG00000169836 Target class GPCR Chromosome 4 Approved drugs 1 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** Yes ## Names **Target name** TACR3 **Gene name** Tachykinin receptor 3 **Gene symbol** TACR3 **Protein name** Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) ### Other names (3) - NK3R - NKR - TAC3R ## Classification **Gene biotype** Protein coding **Gene family** Tachykinin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 2 **Highest tissue expression** 1.34 **Tissue specificity (Gini)** 0.838 **Tissue specificity (tau)** 0.943 ## Pathways and interactions **KEGG gene identifiers** - hsa:6870 **Protein interaction confidence** 0.836 **Protein interaction partners** 11 ### Reactome pathways (2) - R-HSA-380095 - R-HSA-416476 ## Genomic location **End position** 103719985 **Start position** 103586031 **Chromosome** 4 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000169836 **HGNC ID** HGNC:11528 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11528) **NCBI Gene ID** 6870 **UniProt ID** P29371 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence - PubMed 37968728 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37968728/) ## Tissue expression **Tissue specificity (tau)** 0.942551 **Expression inequality (Gini)** 0.838048 ### Highest expression Expression in transcripts per million **Brain - Hypothalamus** 1.34 **Bladder** 1.16 **Brain - Spinal cord (cervical c-1)** 0.51 **Brain - Substantia nigra** 0.42 **Brain - Amygdala** 0.38 ### All tissues (54) Expression in transcripts per million - Brain - Hypothalamus1.34 - Bladder1.16 - Brain - Spinal cord (cervical c-1)0.51 - Brain - Substantia nigra0.42 - Brain - Amygdala0.38 - Brain - Hippocampus0.25 - Brain - Frontal Cortex (BA9)0.16 - Kidney - Cortex0.16 - Brain - Anterior cingulate cortex (BA24)0.16 - Brain - Nucleus accumbens (basal ganglia)0.14 - Brain - Cortex0.14 - Brain - Putamen (basal ganglia)0.12 - Brain - Caudate (basal ganglia)0.11 - Testis0.08 - Pituitary0.06 - Lung0.05 - Muscle - Skeletal0.03 - Kidney - Medulla0.03 - Brain - Cerebellar Hemisphere0.02 - Thyroid0.02 - Brain - Cerebellum0.02 - Skin - Sun Exposed (Lower leg)0.02 - Stomach0.01 - Colon - Transverse0.01 - Small Intestine - Terminal Ileum0.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007209) - GO:0007217 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007217) - GO:1902093 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902093) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0097225 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097225) ### Molecular functions (3) - GO:0004995 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004995) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016498 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016498) ## On-target safety - Contraction of gastric smooth muscle and ileum ### Effects - Activation/Increase/Upregulation ### Studies - preclinical ### Biological samples - GI PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Related records ### Trials (87) - A 24-52-week Study to Evaluate the Long-term Efficacy and Safety of Saredutant in Patients With Depression (MAGENTA) - A Dose-ranging Study of the Efficacy of ESN364 in Postmenopausal Women Suffering Vasomotor Symptoms (Hot Flashes) - A Fifty-two-week Study to Evaluate the Safety of Saredutant in Adult and Elderly Patients With Depression - A North-American Eight-week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Generalized Anxiety Disorder - A Phase 1 Study of Substance P-Saporin in Terminal Cancer Patients With Intractable Pain - A Study Evaluating the Safety and Tolerability of Abrupt Discontinuation of Saredutant in Patients With Depression - A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats - A Study in Canada to Follow Outcomes of Women in Menopause Treated With Fezolinetant for Hot Flashes, When Given in Clinical Practice - A Study in Germany to Learn About the Value of Fezolinetant in Treating Hot Flashes and Night Sweats in Women During Menopause - A Study of AZD4901 in Females With Polycystic Ovary Syndrome - A Study of BAY3427080 (NT-814) in the Treatment of Moderate to Severe Post-menopausal Vasomotor Symptoms - A Study of Fezolinetant to Treat Hot Flashes in Women Going Through Menopause - A Study to Assess Bioequivalence of Fezolinetant Formulations in Healthy Female Participants - A Study to Assess Long-term Safety of Fezolinetant Given to Japanese Women Going Through Menopause - A Study to Assess the Effect of Food With Fezolinetant in Healthy Female Participants - A Study to Assess the Safety and Tolerability of Fezolinetant in Women Seeking Treatment for Relief of Vasomotor Symptoms (VMS) Associated With Menopause - A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ESN364 in Healthy Japanese Male and Pre- and Post-menopausal Female Subjects - A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Chinese Women Going Through Menopause - A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Japanese Women Going Through Menopause - [A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Women With Breast Cancer Who Are Having Hormone Therapy](https://trialight.com/data/trial/a-study-to-confirm-if-fezolinetant-helps-reduce-hot-flashes-7c0717ff-baca-4c04-a97a-6ce0f226799e.md) ### Drugs (9) - Eledoisin - Elinzanetant Neurokinin 3 receptor antagonist - [Fezolinetant](https://trialight.com/data/asset/fezolinetant-9dd0ce26-b5de-4f55-b95e-e1b67eb0b69f.md) Neurokinin 3 receptor antagonist - Osanetant - Pavinetant Neurokinin 3 receptor antagonist - Saredutant - Substance P - Talnetant Neurokinin 3 receptor antagonist - Talnetant hydrochloride Neurokinin 3 receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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