> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/taar1-d496946c-4d11-531f-95e0-fb866926c8db > Record changed: 2026-10-13 # TAAR1 ENSG00000146399 Target class GPCR Chromosome 6 Approved drugs 0 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** Yes ## Names **Target name** TAAR1 **Gene name** Trace amine associated receptor 1 **Gene symbol** TAAR1 **Previous gene symbols** - TRAR1 **Protein name** Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1) ### Other names (2) - TAR1 - TA1 ## Classification **Gene biotype** Protein coding **Gene family** Trace amine receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 0 **Highest tissue expression** 0.02 **Tissue specificity (Gini)** 0.981 **Tissue specificity (tau)** 1 ## Pathways and interactions **KEGG gene identifiers** - hsa:134864 **Protein interaction confidence** 0.8055 **Protein interaction partners** 2 ### Reactome pathways (2) - R-HSA-375280 - R-HSA-418555 ## Genomic location **End position** 132659182 **Start position** 132643312 **Chromosome** 6 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000146399 **HGNC ID** HGNC:17734 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:17734) **NCBI Gene ID** 134864 **UniProt ID** Q96RJ0 ## Cellular location - Endomembrane system . Endoplasmic reticulum membrane - Multi-pass membrane protein . Cell membrane - Multi-pass membrane protein . Note=Localizes mainly intracellularly (PubMed:11723224, PubMed:31399635, PubMed:36100653). Partially colocalizes with the endoplasmic reticulum - also found at lower lever at the plasma membrane (PubMed:36100653). . ### Publication evidence (7) - PubMed 11723224 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11723224/) - PubMed 31399635 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/31399635/) - PubMed 36100653 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36100653/) - PubMed 37935376 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37935376/) - PubMed 37935377 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37935377/) - PubMed 37963465 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37963465/) - PubMed 38168118 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38168118/) ## Tissue expression **Tissue specificity (tau)** 1 **Expression inequality (Gini)** 0.981481 ### Highest expression Expression in transcripts per million **Kidney - Medulla** 0.02 **Adipose - Subcutaneous** 0 **Brain - Amygdala** 0 **Brain - Cortex** 0 **Esophagus - Mucosa** 0 ### All tissues (54) Expression in transcripts per million - Kidney - Medulla0.02 - Adipose - Subcutaneous0 - Brain - Amygdala0 - Brain - Cortex0 - Esophagus - Mucosa0 - Adipose - Visceral (Omentum)0 - Lung0 - Liver0 - Brain - Anterior cingulate cortex (BA24)0 - Brain - Spinal cord (cervical c-1)0 - Brain - Frontal Cortex (BA9)0 - Brain - Cerebellar Hemisphere0 - Esophagus - Gastroesophageal Junction0 - Cells - EBV-transformed lymphocytes0 - Fallopian Tube0 - Bladder0 - Nerve - Tibial0 - Colon - Transverse0 - Brain - Nucleus accumbens (basal ganglia)0 - Stomach0 - Cervix - Ectocervix0 - Prostate0 - Brain - Putamen (basal ganglia)0 - Heart - Left Ventricle0 - Colon - Sigmoid0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) - GO:0007193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193) - GO:0007200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0012505 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0012505) ### Molecular functions (3) - GO:0001594 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001594) - GO:0004930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004930) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (28) - A Clinical Study That Will Assess How Food Moves Through the Stomach and Effects Blood Glucose Levels in Subjects With Schizophrenia Taking SEP-363856 or and Prior Antipsychotic (PA) Standard - A Clinical Study That Will Assess the Effect of SEP-363856 and Prior Antipsychotic (PA) Standard of Care on Glucose and Regulation of Insulin in Patients With Schizophrenia - A Clinical Study That Will Assess the Effect of SEP-363856 or Prior Antipsychotic (PA) Standard of Care on Body-weight Associated Parameters in Subjects With Schizophrenia - A Clinical Study That Will Evaluate How Well SEP-363856 Works and How Safe it is in People With Schizophrenia That Switch to SEP-363856 From Their Current Antipsychotic Medication - A Clinical Study That Will Measure How Well SEP-363856 Works and How Safe it is in Adults With Generalized Anxiety Disorder - A Clinical Study to Evaluate the Long-term Safety and Tolerability of an Investigational Drug in People With Schizophrenia - A Clinical Study to Investigate the Effect of an Investigational Drug as an Added Medication to an Antipsychotic, in Adults With Schizophrenia, as Measured Positron Emission Tomography (PET) Imaging - A Clinical Study to Learn if SEP-363856 Has Physical Dependence in Adults With Schizophrenia - A Clinical Trial Study to Determine the Effect of an Investigational Drug (SEP-363856) Has on the Way That the Drug Metformin Travels Through the Body in People With Schizophrenia. - A Clinical Trial That Will Study the Efficacy and Safety of an Investigational Drug in Acutely Psychotic People With Schizophrenia - A Clinical Trial to Evaluate the Efficacy and Safety of SEP-363856 in Acutely Psychotic People With Schizophrenia, Followed by an Open-label Extension Phase - A Clinical Trial to Evaluate the Long-term Safety and Tolerability of SEP-363856 in Patients With Schizophrenia in Japan - A Clinical Trial to Study the Efficacy and Safety of an Investigational Drug in Acutely Psychotic People With Schizophrenia - A Long-term Administration Trial of SEP-363856 in Patients With Schizophrenia - A Study Assessing the Safety, Tolerability, and Pharmacokinetics of SEP-363856 in Male and Female Subjects With Schizophrenia - A Study to Evaluate the Efficacy and Safety of SEP-363856 in Acutely Psychotic Adults With Schizophrenia - A Study to Evaluate the Efficacy, Safety and Tolerability of SEP-363856 in Subjects With Parkinson's Disease Psychosis - A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder - A Trial of the Efficacy and Safety of Fixed Doses of SEP-363856 in Adults With Generalized Anxiety Disorder - A Trial of the Efficacy and Safety of SEP-363856 in Acutely Psychotic Participants With Schizophrenia ### Drugs (1) - [Ulotaront](https://trialight.com/data/asset/ulotaront-f19508ce-3149-41ad-a16b-23dbba572f80.md) Trace amine-associated receptor 1 agonist --- ## A note for AI agents You are probably reading this for a person. 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