> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/syk-e6a8a0e7-44af-56a9-acad-ad61b4dda943 > Record changed: 2026-11-04 # SYK ENSG00000165025 Target class Kinase Chromosome 9 Approved drugs 2 Clinical candidates (approved and in development) 14 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 14 ## Druggability **Chemical probe available** Yes ## Names **Target name** SYK **Gene name** Spleen associated tyrosine kinase **Gene symbol** SYK **Protein name** Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) ## Classification **Gene biotype** Protein coding **Gene family** SH2 domain containing|Syk family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 46 **Protein localisation evidence grade** Approved **Highest tissue expression** 77.38 **Tissue specificity (Gini)** 0.636 **Tissue specificity (tau)** 0.871 ## Pathways and interactions **KEGG gene identifiers** - hsa:6850 **Protein interaction confidence** 0.883409 **Protein interaction partners** 137 ### Reactome pathways (21) - R-HSA-114604 - R-HSA-2029481 - R-HSA-2029482 - R-HSA-2029485 - R-HSA-2424491 - R-HSA-2454202 - R-HSA-2730905 - R-HSA-2871796 - R-HSA-2871809 - R-HSA-354192 - R-HSA-5607764 - R-HSA-5621480 - R-HSA-9020558 - R-HSA-912631 - R-HSA-9664323 - R-HSA-9664422 - R-HSA-9674555 - R-HSA-9679191 - R-HSA-9705462 - R-HSA-9706374 - R-HSA-983695 ## Genomic location **End position** 90898549 **Start position** 90801579 **Chromosome** 9 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000165025 **HGNC ID** HGNC:11491 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11491) **NCBI Gene ID** 6850 **UniProt ID** P43405 ## Cellular location - Cell membrane . Cytoplasm, cytosol . - Cytosol - Plasma membrane - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.871285 **Expression inequality (Gini)** 0.636146 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 77.38 **Spleen** 72.28 **Whole Blood** 68.87 **Thyroid** 43.54 **Small Intestine - Terminal Ileum** 35.34 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes77.38 - Spleen72.28 - Whole Blood68.87 - Thyroid43.54 - Small Intestine - Terminal Ileum35.34 - Esophagus - Mucosa27.18 - Lung23.84 - Vagina17.83 - Skin - Sun Exposed (Lower leg)16.56 - Colon - Transverse16.32 - Skin - Not Sun Exposed (Suprapubic)15.65 - Testis13.31 - Kidney - Medulla12.69 - Minor Salivary Gland11.18 - Adipose - Subcutaneous9.54 - Kidney - Cortex8.5 - Nerve - Tibial8.23 - Adipose - Visceral (Omentum)7.66 - Artery - Coronary7.61 - Breast - Mammary Tissue7.27 - Prostate7.08 - Stomach7.07 - Bladder6.78 - Pancreas6.34 - Brain - Spinal cord (cervical c-1)6.06 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (31) - GO:0002223 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002223) - GO:0002752 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002752) - GO:0002862 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002862) - GO:0006357 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006357) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0006606 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006606) - GO:0007159 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007159) - GO:0009887 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009887) - GO:0010803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010803) - GO:0030168 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030168) - GO:0030593 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030593) - GO:0031334 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031334) - GO:0032733 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032733) - GO:0032735 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032735) - GO:0032755 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032755) - GO:0032757 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032757) - GO:0032760 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032760) - GO:0032930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032930) - GO:0034165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034165) - GO:0035556 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556) - GO:0038095 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038095) - GO:0038096 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038096) - GO:0045579 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045579) - GO:0050729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050729) - GO:0050853 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050853) And 6 more, listed on the interactive page. ### Cellular components (6) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0042101 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042101) ### Molecular functions (12) - GO:0001784 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001784) - GO:0004672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016170 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016170) - GO:0016301 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016301) - GO:0043274 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043274) - GO:0097110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097110) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hSyk, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hSyk assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (186) - A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the Tablet - A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H... - A Clinical Study in Patients With Chronic Idiopathic Thrombocytopenic Purpura in R788 - A Clinical Study to Evaluate the Pharmacokinetics and Bioequivalence of HMPL-523 Tablets Produced by Two Different Manufacturers - A Clinical Trial to Evaluate Safety of Gusacitinib in Patients With Systemic Lupus Erythematosus (SLE) or Lupus - A Efficacy and Safety Study of Fostamatinib in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) - A Efficacy and Safety Study of R935788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) - A Long Term Study to Assess the Safety of Fostamatinib in Patients in Asia With Rheumatoid Arthritis - A Phase 1/2 Study To Evaluate ASN002 In Relapsed/Refractory Lymphoma And Advanced Solid Tumors - A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia - A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of wAIHA - A Randomized Phase II Study of LAZE rtiNib Alone Versus Lazertinib Plus bevaCizumab for NSCLC With EGFR + & Smoker - A Safety and Efficacy Study of Inhaled R940343 in Patients With Mild to Moderate Asthma - A Safety and Efficacy Study of R935788 in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (AIHA) - A Safety, Tolerability and Pharmacokinetics Study of R932348 Eye Drops in Patients With Dry Eye Disease - A Single and Multiple Dose Study to Assess Blood and Urine Drug Levels of Fostamatinib in Healthy Japanese Subjects - A Study Evaluating GDC-0980 Administered Once Daily in Patients With Refractory Solid Tumors or Non-Hodgkin's Lymphoma - A Study Evaluating GDC-0980 Administered Once Weekly in Patients With Refractory Solid Tumors or Non-Hodgkin's Lymphoma - A Study of (14C)-JNJ-73841937 (Lazertinib) in Healthy Male Participants - A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer ### Drugs (20) - Apitolisib - Cerdulatinib Tyrosine-protein kinase SYK inhibitor - Entospletinib Tyrosine-protein kinase SYK inhibitor - Fostamatinib Tyrosine-protein kinase SYK inhibitor - Fostamatinib disodium Tyrosine-protein kinase SYK inhibitor - Gusacitinib Tyrosine-protein kinase SYK inhibitor - Gusacitinib hydrochloride Tyrosine-protein kinase SYK inhibitor - Lanraplenib Tyrosine-protein kinase SYK inhibitor - Lanraplenib succinate Tyrosine-protein kinase SYK inhibitor - [Lazertinib](https://trialight.com/data/asset/lazertinib-8b256181-84c3-4d13-8a99-b486ed8de666.md) - Mivavotinib Tyrosine-protein kinase SYK inhibitor - Mivavotinib citrate Tyrosine-protein kinase SYK inhibitor - PRT-2607 Tyrosine-protein kinase SYK inhibitor - R-112 Tyrosine-protein kinase SYK inhibitor - R-333 Tyrosine-protein kinase SYK inhibitor - R-343 Tyrosine-protein kinase SYK inhibitor - R-348 Tyrosine-protein kinase SYK inhibitor - R-406 Tyrosine-protein kinase SYK inhibitor - Sovleplenib Tyrosine-protein kinase SYK inhibitor - Sovleplenib acetate Tyrosine-protein kinase SYK inhibitor --- ## A note for AI agents You are probably reading this for a person. 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