> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/sts-e89e2f4f-fc52-56e8-b0b4-b61f2c9cd8d3 > Record changed: 2026-10-13 # STS ENSG00000101846 Target class Enzyme Chromosome X Approved drugs 0 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** Yes ## Names **Other names** - ARSC **Target name** STS **Gene name** Steroid sulfatase **Gene symbol** STS **Previous gene symbols** - ARSC1 **Protein name** Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Estrone sulfatase) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase) ## Classification **Gene biotype** Protein coding **Gene family** Sulfatases|MicroRNA protein coding host genes **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 26.18 **Tissue specificity (Gini)** 0.361 **Tissue specificity (tau)** 0.746 ## Pathways and interactions **KEGG gene identifiers** - hsa:412 **Protein interaction confidence** 0.847278 **Protein interaction partners** 36 ### Reactome pathways (3) - R-HSA-1663150 - R-HSA-196071 - R-HSA-9840310 ## Genomic location **End position** 7804358 **Start position** 7147237 **Chromosome** X **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000101846 **HGNC ID** HGNC:11425 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11425) **NCBI Gene ID** 412 **UniProt ID** P08842 ## Cellular location - Cytoplasmic vesicle, secretory vesicle, microneme membrane - Multi-pass membrane protein. Endoplasmic reticulum membrane - Multi-pass membrane protein. ### Publication evidence - PubMed 2668275 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2668275/) ## Tissue expression **Tissue specificity (tau)** 0.746198 **Expression inequality (Gini)** 0.360942 ### Highest expression Expression in transcripts per million **Artery - Tibial** 26.18 **Cells - Cultured fibroblasts** 18.89 **Artery - Coronary** 16.99 **Adipose - Subcutaneous** 16.72 **Cells - EBV-transformed lymphocytes** 16.29 ### All tissues (54) Expression in transcripts per million - Artery - Tibial26.18 - Cells - Cultured fibroblasts18.89 - Artery - Coronary16.99 - Adipose - Subcutaneous16.72 - Cells - EBV-transformed lymphocytes16.29 - Brain - Frontal Cortex (BA9)14.14 - Artery - Aorta13.83 - Lung11.93 - Adipose - Visceral (Omentum)11.66 - Nerve - Tibial11.05 - Breast - Mammary Tissue10.82 - Fallopian Tube9.1 - Brain - Cortex8.76 - Cervix - Ectocervix8.3 - Thyroid8.17 - Cervix - Endocervix8.03 - Vagina7.82 - Bladder7.65 - Prostate7.33 - Ovary6.88 - Uterus6.55 - Brain - Anterior cingulate cortex (BA24)6.48 - Stomach6.03 - Esophagus - Gastroesophageal Junction5.6 - Brain - Hypothalamus5.58 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0006706 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006706) - GO:0008544 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008544) ### Cellular components (9) - GO:0005764 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0043231 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043231) ### Molecular functions (2) - GO:0004773 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004773) - GO:0008484 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008484) ## Related records ### Trials (87) - A Clinical Trial on the Outcomes of Comprehensive Enhanced Prophylaxis Management (CEPM) in Chinese Patients With EGFR-Mutated Advanced NSCLC Receiving Amivantamab-Based Regimens - A Clinical Trial to Evaluate Tolerability and Pharmacokinetics of HL217 Eye Drop in Healthy Male Subjects - A Dose-escalation Clinical Trial After Multiple Dosing of HL217 Eye Drop in Healthy Male Subjects - A Dose-range Finding Study of MAA868 in Patients With Atrial Fibrillation - A Long-term Safety Study of Infliximab in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD). - A Pharmacokinetic Study of Abiraterone Acetate in Patients With Severe Hepatic Impairment Compared to Patients With Normal Hepatic Function - [A Phase Ib/II Trial of HS-20110 Combination Therapies in Advanced Colorectal Cancer Patients.](https://trialight.com/data/trial/a-phase-ib-ii-trial-of-hs-20110-combination-therapies-in-8d9fea0b-a918-4853-be08-ce877534dfaa.md) - A Safety Study of Abiraterone Acetate Administered in Combination With Docetaxel in Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC) - A Single-Dose Open-Label Study of XOMA 358 in Subjects With Congenital Hyperinsulinism - A Study Combining Ibrutinib With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With CD20-Positive B-Cell Non Hodgkin Lymphoma - A Study of Apatinib Combined With Letrozole With or Without Fluzoparib in Estrogen Receptor-Positive, Platinum-Sensitive Recurrent Ovarian Cancer Previously Treated With First-Line PARP Inhibitor - A Study of ATB1651 in Adults With Mild to Moderate Onchomycosis - A Study of AV0328 Administered to Healthy Adult Volunteers - A Study of GSK2110183 in Subjects With Proteasome Inhibitor Refractory Multiple Myeloma - A Study of HDC/IL-2 Treatment in Chronic Myelomonocytic Leukemia (CMML) - A Study of JNJ-40346527 in Patients With Relapsed or Refractory Hodgkin Lymphoma - A Study of M701 (EpCAM and CD3) in Malignant Ascites - A Study of Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of KAN-101 in Celiac Disease (ACeD-it) - A Study of SY-1365 in Adult Patients With Advanced Solid Tumors - A Study of the Safety and Effectiveness of Irosustat When Added to an AI in ER+ve Locally Advanced or Metastatic Breast Cancer. ### Drugs (1) - [Irosustat](https://trialight.com/data/asset/irosustat-127d5444-c8ee-4eb6-9be9-b5981033e1b0.md) Steryl-sulfatase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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