STS
ENSG00000101846
Target class
Enzyme
Chromosome
X
Approved drugs
0
Clinical candidates (approved and in development)
1
- Approved drugs
- 0
- Clinical candidates (approved and in development)
- 1
- Chemical probe available
- Yes
- Other names
- ARSC
- Target name
- STS
- Gene name
- Steroid sulfatase
- Gene symbol
- STS
- Previous gene symbols
- ARSC1
- Protein name
- Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Estrone sulfatase) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase)
- Gene biotype
- Protein coding
- Gene family
- Sulfatases|MicroRNA protein coding host genes
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 54
- Highest tissue expression
- 26.18
- Tissue specificity (Gini)
- 0.361
- Tissue specificity (tau)
- 0.746
- KEGG gene identifiers
- hsa:412
- Protein interaction confidence
- 0.847278
- Protein interaction partners
- 36
- R-HSA-1663150
- R-HSA-196071
- R-HSA-9840310
- End position
- 7804358
- Start position
- 7147237
- Chromosome
- X
- Strand
- Forward
- Cytoplasmic vesicle, secretory vesicle, microneme membrane
- Multi-pass membrane protein. Endoplasmic reticulum membrane
- Multi-pass membrane protein.
Publication evidence
- PubMed 2668275
- Tissue specificity (tau)
- 0.746198
- Expression inequality (Gini)
- 0.360942
Expression in transcripts per million
- Artery - Tibial
- 26.18
- Cells - Cultured fibroblasts
- 18.89
- Artery - Coronary
- 16.99
- Adipose - Subcutaneous
- 16.72
- Cells - EBV-transformed lymphocytes
- 16.29
Expression in transcripts per million
- Artery - Tibial26.18
- Cells - Cultured fibroblasts18.89
- Artery - Coronary16.99
- Adipose - Subcutaneous16.72
- Cells - EBV-transformed lymphocytes16.29
- Brain - Frontal Cortex (BA9)14.14
- Artery - Aorta13.83
- Lung11.93
- Adipose - Visceral (Omentum)11.66
- Nerve - Tibial11.05
- Breast - Mammary Tissue10.82
- Fallopian Tube9.1
- Brain - Cortex8.76
- Cervix - Ectocervix8.3
- Thyroid8.17
- Cervix - Endocervix8.03
- Vagina7.82
- Bladder7.65
- Prostate7.33
- Ovary6.88
- Uterus6.55
- Brain - Anterior cingulate cortex (BA24)6.48
- Stomach6.03
- Esophagus - Gastroesophageal Junction5.6
- Brain - Hypothalamus5.58
And 29 more, listed on the interactive page.
- GO:0006706
- GO:0008544
- GO:0005764
- GO:0005768
- GO:0005783
- GO:0005788
- GO:0005789
- GO:0005794
- GO:0005886
- GO:0016020
- GO:0043231
- GO:0004773
- GO:0008484
Related records
Trials (87)
- A Clinical Trial on the Outcomes of Comprehensive Enhanced Prophylaxis Management (CEPM) in Chinese Patients With EGFR-Mutated Advanced NSCLC Receiving Amivantamab-Based Regimens
- A Clinical Trial to Evaluate Tolerability and Pharmacokinetics of HL217 Eye Drop in Healthy Male Subjects
- A Dose-escalation Clinical Trial After Multiple Dosing of HL217 Eye Drop in Healthy Male Subjects
- A Dose-range Finding Study of MAA868 in Patients With Atrial Fibrillation
- A Long-term Safety Study of Infliximab in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).
- A Pharmacokinetic Study of Abiraterone Acetate in Patients With Severe Hepatic Impairment Compared to Patients With Normal Hepatic Function
- A Phase Ib/II Trial of HS-20110 Combination Therapies in Advanced Colorectal Cancer Patients.
- A Safety Study of Abiraterone Acetate Administered in Combination With Docetaxel in Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
- A Single-Dose Open-Label Study of XOMA 358 in Subjects With Congenital Hyperinsulinism
- A Study Combining Ibrutinib With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With CD20-Positive B-Cell Non Hodgkin Lymphoma
- A Study of Apatinib Combined With Letrozole With or Without Fluzoparib in Estrogen Receptor-Positive, Platinum-Sensitive Recurrent Ovarian Cancer Previously Treated With First-Line PARP Inhibitor
- A Study of ATB1651 in Adults With Mild to Moderate Onchomycosis
- A Study of AV0328 Administered to Healthy Adult Volunteers
- A Study of GSK2110183 in Subjects With Proteasome Inhibitor Refractory Multiple Myeloma
- A Study of HDC/IL-2 Treatment in Chronic Myelomonocytic Leukemia (CMML)
- A Study of JNJ-40346527 in Patients With Relapsed or Refractory Hodgkin Lymphoma
- A Study of M701 (EpCAM and CD3) in Malignant Ascites
- A Study of Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of KAN-101 in Celiac Disease (ACeD-it)
- A Study of SY-1365 in Adult Patients With Advanced Solid Tumors
- A Study of the Safety and Effectiveness of Irosustat When Added to an AI in ER+ve Locally Advanced or Metastatic Breast Cancer.
Drugs (1)
- Irosustat Steryl-sulfatase inhibitor