> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/src-fc2e1cbe-dc5a-5132-aa5f-e132878398aa > Record changed: 2026-11-04 # SRC ENSG00000197122 Target class Kinase Chromosome 20 Approved drugs 4 Clinical candidates (approved and in development) 13 ## Clinical evidence **Approved drugs** 4 **ClinGen gene-disease validity** Moderate **Clinical candidates (approved and in development)** 13 ## Druggability **Chemical probe available** Yes ## Names **Target name** SRC **Gene name** SRC proto-oncogene, non-receptor tyrosine kinase **Gene symbol** SRC **Previous gene symbols** - SRC1 **Protein name** Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) ### Other names (2) - ASV - c-src ## Classification **Gene biotype** Protein coding **Gene family** SH2 domain containing|Src family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 59.33 **Tissue specificity (Gini)** 0.378 **Tissue specificity (tau)** 0.615 ## Pathways and interactions **KEGG gene identifiers** - hsa:6714 **Protein interaction confidence** 0.86208 **Protein interaction partners** 398 ### Reactome pathways (38) - R-HSA-1227986 - R-HSA-1251985 - R-HSA-1253288 - R-HSA-1257604 - R-HSA-180292 - R-HSA-186763 - R-HSA-2219530 - R-HSA-354192 - R-HSA-354194 - R-HSA-372708 - R-HSA-418555 - R-HSA-418594 - R-HSA-418885 - R-HSA-418886 - R-HSA-428542 - R-HSA-5673000 - R-HSA-5674135 - R-HSA-6802946 - R-HSA-6802948 - R-HSA-6802952 - R-HSA-6802955 - R-HSA-6811558 - R-HSA-8874081 - R-HSA-8876493 - R-HSA-8934593 And 13 more, listed on the interactive page. ## Genomic location **End position** 37406050 **Start position** 37344673 **Chromosome** 20 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000197122 **HGNC ID** HGNC:11283 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11283) **NCBI Gene ID** 6714 **UniProt ID** P12931 ## Cellular location - Cell membrane - Lipid-anchor . Mitochondrion inner membrane . Nucleus . Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell junction, focal adhesion . Cell junction . Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268). Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596). . - Cell Junctions - Plasma membrane - Vesicles ### Publication evidence (6) - PubMed 7525268 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7525268/) - PubMed 22801373 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22801373/) - PubMed 12615910 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12615910/) - PubMed 7853507 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7853507/) - PubMed 19307596 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19307596/) - PubMed 22294297 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22294297/) ## Tissue expression **Tissue specificity (tau)** 0.615063 **Expression inequality (Gini)** 0.378482 ### Highest expression Expression in transcripts per million **Uterus** 59.33 **Testis** 55.27 **Bladder** 52.02 **Prostate** 51.54 **Cervix - Ectocervix** 49.82 ### All tissues (54) Expression in transcripts per million - Uterus59.33 - Testis55.27 - Bladder52.02 - Prostate51.54 - Cervix - Ectocervix49.82 - Cervix - Endocervix46.22 - Artery - Aorta45.16 - Cells - EBV-transformed lymphocytes44.4 - Fallopian Tube42.67 - Vagina41.96 - Colon - Sigmoid41.37 - Ovary40.16 - Stomach36.91 - Colon - Transverse36.3 - Small Intestine - Terminal Ileum34.57 - Esophagus - Mucosa32.5 - Adrenal Gland31.84 - Pituitary29.1 - Esophagus - Gastroesophageal Junction28.92 - Kidney - Medulla27.24 - Lung26.68 - Esophagus - Muscularis25.86 - Artery - Tibial24.43 - Spleen22.2 - Nerve - Tibial21.55 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (50) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0002223 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002223) - GO:0002862 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002862) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007172 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007172) - GO:0007173 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007173) - GO:0007179 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007179) - GO:0007229 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007229) - GO:0010632 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010632) - GO:0010634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010634) - GO:0016236 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016236) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0022407 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022407) - GO:0030168 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030168) - GO:0031295 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031295) - GO:0031333 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031333) - GO:0032205 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032205) - GO:0033625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033625) - GO:0034139 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034139) - GO:0034614 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034614) - GO:0035306 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035306) - GO:0035331 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035331) - GO:0035556 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556) - GO:0038096 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038096) - GO:0038128 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038128) And 25 more, listed on the interactive page. ### Cellular components (14) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005743) - GO:0005764 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764) - GO:0005770 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005770) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005901) - GO:0005911 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005911) - GO:0030054 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030054) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0070161 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070161) ### Molecular functions (17) - GO:0004672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016004 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016004) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0020037 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0020037) - GO:0042169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042169) - GO:0043274 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043274) - GO:0044325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044325) - GO:0045296 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045296) - GO:0046875 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046875) - GO:0051219 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051219) - GO:0070700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070700) - GO:0097110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097110) ## On-target safety - pulmonary arterial hypertension ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - pulmonary oedema ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - respiratory PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - cell hypertrophy ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Abnormal behaviour ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Pleural effusion ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - respiratory PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - cognitive disorder ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - anxiety ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - bone disorder ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - bone PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - thrombocytopenia ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - blood PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - deep vein thrombosis ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - platelet dysfunction ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - blood/bone marrow PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Off-target safety - regulation of catalytic activity ### Studies (2) - biochemical: NVS\_ENZ\_hSRC, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hSRC assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. - biochemical: NVS\_ENZ\_hSRC, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hSRC assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (1,487) - A Bioequivalence Study of Dasatinib Tablet - A Clincal Study of Max-40279-01 in Patients With Advanced Colorectal Cancer - A Clinical Study of Adebrelimab Combined With Apatinib and Paclitaxel in Patients With Advanced Gastric Cancer. - A Clinical Study of Apatinib in Patients With Local Progressive/Metastatic Refractory Thyroid Cancer - A Clinical Study To Evaluate Camrelizumab (SHR-1210) Plus Capecitabine and Oxaliplatin Followed by Sequential Treatment With Camrelizumab Plus Apatinib Mesylate in Advanced or Metastatic Gastric Cancer (GC) or Gastroesophageal Junction Cancer (GEJ) Without Prior Systemic Therapy - A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST - A Clinical Trial of Apatinib Plus Docetaxel in Locally Advanced or Metastatic Gastric or GEJ Adenocarcinoma - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Clinical Trial With Apatinib for Subjects With Refractory Malignant Ascites - A Combination of Acalabrutinib With R-CHOP for Patient Diffuse Large B-cell Lymphoma (DLBCL) - A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312) - A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma - A Crossover Study to Evaluate the Bioavailability of Ibrutinib Suspension and Sprinkle Formulations Compared to Capsules in Healthy Adults - A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420. - A Dose-Escalation Study of ENMD-2076 Administered Orally to Patients With Advanced Cancer - A Drug Interaction Study Between Bosutinib And Aprepitant In Healthy Volunteers - A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults - [A LM-302 Combination With Other Anti-Tumor Therapies Phase ll Study](https://trialight.com/data/trial/a-lm-302-combination-with-other-anti-tumor-therapies-phase-f867e7b8-f10d-4281-8491-ff6441459c77.md) - A Long-term Extension Study of PCI-32765 (Ibrutinib) - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Lymphomas ### Drugs (27) - [Acalabrutinib](https://trialight.com/data/asset/acalabrutinib-17f298f9-e056-45ab-95dc-9a5b0f25c869.md) - AZD-0424 Tyrosine-protein kinase SRC inhibitor - AZM-475271 Tyrosine-protein kinase SRC inhibitor - Balamapimod - Bosutinib Tyrosine-protein kinase SRC inhibitor - Dasatinib - Dasatinib anhydrous SRC inhibitor - Dasatinib laurylsulfate SRC inhibitor - Elzovantinib - ENMD-2076 - ENMD-981693 SRC inhibitor - [Ibrutinib](https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d.md) - Ilorasertib SRC inhibitor - JNJ-26483327 Tyrosine-protein kinase SRC inhibitor - KX2-361 - Nefextinib - PD-0166285 Tyrosine-protein kinase SRC inhibitor - PD-0166285 hydrochloride Tyrosine-protein kinase SRC inhibitor - [Rivoceranib](https://trialight.com/data/asset/rivoceranib-77932dd2-2af1-44e3-ba1a-24c963386df3.md) - Saracatinib Tyrosine-protein kinase SRC inhibitor --- ## A note for AI agents You are probably reading this for a person. 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