SRC

ENSG00000197122
Target class
Kinase
Chromosome
20
Approved drugs
4
Clinical candidates (approved and in development)
13

Approved drugs
4
ClinGen gene-disease validity
Moderate
Clinical candidates (approved and in development)
13

Chemical probe available
Yes

Target name
SRC
Gene name
SRC proto-oncogene, non-receptor tyrosine kinase
Gene symbol
SRC
Previous gene symbols
  • SRC1
Protein name
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)

  • ASV
  • c-src

Gene biotype
Protein coding
Gene family
SH2 domain containing|Src family tyrosine kinases
Target class
Kinase
Target type
Human gene

Tissues expressed in
54
Protein localisation evidence grade
Supported
Highest tissue expression
59.33
Tissue specificity (Gini)
0.378
Tissue specificity (tau)
0.615

KEGG gene identifiers
  • hsa:6714
Protein interaction confidence
0.86208
Protein interaction partners
398

  • R-HSA-1227986
  • R-HSA-1251985
  • R-HSA-1253288
  • R-HSA-1257604
  • R-HSA-180292
  • R-HSA-186763
  • R-HSA-2219530
  • R-HSA-354192
  • R-HSA-354194
  • R-HSA-372708
  • R-HSA-418555
  • R-HSA-418594
  • R-HSA-418885
  • R-HSA-418886
  • R-HSA-428542
  • R-HSA-5673000
  • R-HSA-5674135
  • R-HSA-6802946
  • R-HSA-6802948
  • R-HSA-6802952
  • R-HSA-6802955
  • R-HSA-6811558
  • R-HSA-8874081
  • R-HSA-8876493
  • R-HSA-8934593

And 13 more, listed on the interactive page.

End position
37406050
Start position
37344673
Chromosome
20
Strand
Forward

Ensembl gene ID
ENSG00000197122
HGNC ID
HGNC:11283
www.genenames.org
NCBI Gene ID
6714
UniProt ID
P12931

  • Cell membrane
  • Lipid-anchor . Mitochondrion inner membrane . Nucleus . Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell junction, focal adhesion . Cell junction . Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268). Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596). .
  • Cell Junctions
  • Plasma membrane
  • Vesicles

Tissue specificity (tau)
0.615063
Expression inequality (Gini)
0.378482

Expression in transcripts per million

Uterus
59.33
Testis
55.27
Bladder
52.02
Prostate
51.54
Cervix - Ectocervix
49.82

Expression in transcripts per million

  • Uterus59.33
  • Testis55.27
  • Bladder52.02
  • Prostate51.54
  • Cervix - Ectocervix49.82
  • Cervix - Endocervix46.22
  • Artery - Aorta45.16
  • Cells - EBV-transformed lymphocytes44.4
  • Fallopian Tube42.67
  • Vagina41.96
  • Colon - Sigmoid41.37
  • Ovary40.16
  • Stomach36.91
  • Colon - Transverse36.3
  • Small Intestine - Terminal Ileum34.57
  • Esophagus - Mucosa32.5
  • Adrenal Gland31.84
  • Pituitary29.1
  • Esophagus - Gastroesophageal Junction28.92
  • Kidney - Medulla27.24
  • Lung26.68
  • Esophagus - Muscularis25.86
  • Artery - Tibial24.43
  • Spleen22.2
  • Nerve - Tibial21.55

And 29 more, listed on the interactive page.

And 25 more, listed on the interactive page.

  • pulmonary arterial hypertension

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • CV
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • pulmonary oedema

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • respiratory
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • cell hypertrophy

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • Abnormal behaviour

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • CNS
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • Pleural effusion

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • respiratory
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • cognitive disorder

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • CNS
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • anxiety

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • CNS
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • bone disorder

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • bone
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • thrombocytopenia

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • blood
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • deep vein thrombosis

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • CV
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • platelet dysfunction

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • blood/bone marrow
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • regulation of catalytic activity

    • biochemical: NVS_ENZ_hSRC, is one of one assay component(s) measured or calculated from the NVS_ENZ_hSRC assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology.
    • biochemical: NVS_ENZ_hSRC, is one of one assay component(s) measured or calculated from the NVS_ENZ_hSRC assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology.

    Biological samples

    • cell-free
    Evidence source
    www.epa.gov

Related records

Trials (1,487)

Drugs (27)