> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/sost-f2355ba2-d85c-5033-b785-2bb5c83919d8 > Record changed: 2026-11-04 # SOST ENSG00000167941 Target class Unclassified protein Chromosome 17 Approved drugs 1 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Target name** SOST **Gene name** Sclerostin **Gene symbol** SOST **Protein name** Sclerostin ### Other names (2) - VBCH - DAND6 ## Classification **Gene biotype** Protein coding **Gene family** DAN family **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 5 **Highest tissue expression** 71.74 **Tissue specificity (Gini)** 0.954 **Tissue specificity (tau)** 0.988 ## Pathways and interactions **KEGG gene identifiers** - hsa:50964 **Protein interaction confidence** 0.819 **Protein interaction partners** 32 ### Reactome pathways (2) - R-HSA-201681 - R-HSA-3772470 ## Genomic location **End position** 43758791 **Start position** 43753738 **Chromosome** 17 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000167941 **HGNC ID** HGNC:13771 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:13771) **NCBI Gene ID** 50964 **UniProt ID** Q9BQB4 ## Cellular location - Secreted, extracellular space, extracellular matrix . ### Publication evidence - PubMed 20551380 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20551380/) ## Tissue expression **Tissue specificity (tau)** 0.988191 **Expression inequality (Gini)** 0.953891 ### Highest expression Expression in transcripts per million **Artery - Aorta** 71.74 **Artery - Tibial** 29.99 **Kidney - Cortex** 7.06 **Artery - Coronary** 4.4 **Kidney - Medulla** 1.82 ### All tissues (54) Expression in transcripts per million - Artery - Aorta71.74 - Artery - Tibial29.99 - Kidney - Cortex7.06 - Artery - Coronary4.4 - Kidney - Medulla1.82 - Heart - Atrial Appendage0.41 - Testis0.12 - Lung0.1 - Skin - Sun Exposed (Lower leg)0.09 - Brain - Frontal Cortex (BA9)0.08 - Nerve - Tibial0.07 - Brain - Cortex0.07 - Vagina0.05 - Thyroid0.04 - Skin - Not Sun Exposed (Suprapubic)0.04 - Spleen0.04 - Prostate0.04 - Adipose - Subcutaneous0.03 - Pituitary0.03 - Brain - Cerebellum0.03 - Brain - Hypothalamus0.03 - Adipose - Visceral (Omentum)0.02 - Fallopian Tube0.02 - Uterus0.02 - Adrenal Gland0.02 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0009612 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009612) - GO:0030514 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030514) - GO:0031333 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031333) - GO:0045893 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045893) - GO:0071374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071374) - GO:0090090 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090090) ### Cellular components - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) ### Molecular functions (4) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030246 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030246) - GO:0140297 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140297) - GO:0140678 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140678) ## Related records ### Trials (61) - A First-in-human Study Evaluating AMG 167 in Healthy Men and Postmenopausal Women - A First-in-human Study Evaluating Romosozumab (AMG 785) in Healthy Men and Postmenopausal Women - A Multiple Dose Study of LY2541546 in Healthy Postmenopausal Women - A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Romosozumab (AMG 785) - A Randomized Phase 3 Study to Evaluate Two Formulations of Romosozumab in Postmenopausal Women With Osteoporosis - A Safety and Efficacy Study to Evaluate Romosozumab (AMG 785) in South Korean Women With Osteoporosis - A Single-dose Study Evaluating Romosozumab (AMG 785) in Healthy Postmenopausal Japanese and Non-Japanese Women - A Study in Adult Patients With Type I, III or IV Osteogenesis Imperfecta Treated With BPS804 - A Study of 2 Different Formulations of Blosozumab (LY2541546) in Post Menopausal Women - A Study of Blosozumab (LY2541546) in Postmenopausal Female Participants - A Study of LY2541546 in Healthy Postmenopausal Women - A Study of LY2541546 in Women With Low Bone Mineral Density - A Study of Romosozumab (EVENITY®) in Postmenopausal Women in India With Osteoporosis at a High Risk of Fracture. - A Study of Romosozumab in People With Breast Cancer and Osteoporosis - A Study of Romosozumab in Women With Multiple Myeloma and Osteoporosis - A Study to Compare the Safety and Efficacy of Romosozumab (AMG 785) Versus Placebo in Men With Osteoporosis - A Study to Evaluate the Effect of Romosozumab (AMG 785) on Bone Quality of the Forearm in Postmenopausal Women With Low Bone Mass - A Study to Test the Efficacy, Safety and Tolerability of Romosozumab Treatment in Postmenopausal Chinese Women With Osteoporosis - An Ascending Multiple Dose Study Evaluating AMG 167 in Healthy Men and Postmenopausal Women With Low Bone Mineral Density - An Exploratory Study of BPS804 Treatment in Adult Patients With Type I, III or IV Osteogenesis Imperfecta ### Drugs (5) - AMG-167 Sclerostin inhibitor - Anti-sclerostin Sclerostin inhibitor - Blosozumab Sclerostin inhibitor - [Romosozumab](https://trialight.com/data/asset/romosozumab-fb80f276-fd9e-412d-9931-fac49b9b05f2.md) Sclerostin inhibitor - Setrusumab Sclerostin inhibitor --- ## A note for AI agents You are probably reading this for a person. 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