> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/sort1-d6fdf338-0d72-5427-ae38-608f5e4c6d23
> Record changed: 2026-11-04

# SORT1

ENSG00000134243

Target class

Membrane receptor

Chromosome

1

## Druggability

**Chemical probe available**

No

## Names

**Target name**

SORT1

**Gene name**

Sortilin 1

**Gene symbol**

SORT1

**Protein name**

Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)

### Other names (2)

- Gp95
- NT3

## Classification

**Gene biotype**

Protein coding

**Target class**

Membrane receptor

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

183.26

**Tissue specificity (Gini)**

0.412

**Tissue specificity (tau)**

0.767

## Pathways and interactions

**KEGG gene identifiers**

- hsa:6272

**Reactome pathways**

- R-HSA-432722

**Protein interaction confidence**

0.847756

**Protein interaction partners**

41

## Genomic location

**End position**

109397967

**Start position**

109309568

**Chromosome**

1

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000134243

**HGNC ID**

HGNC:11186

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11186)

**NCBI Gene ID**

6272

**UniProt ID**

Q99523

## Cellular location

- Golgi apparatus, Golgi stack membrane
- Single-pass type I membrane protein . Endosome membrane
- Single-pass type I membrane protein . Endoplasmic reticulum membrane
- Single-pass type I membrane protein . Nucleus membrane
- Single-pass type I membrane protein . Cell membrane
- Single-pass type I membrane protein
- Extracellular side. Lysosome membrane
- Single-pass type I membrane protein . Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin.
- Cytosol
- Golgi apparatus
- Plasma membrane

### Publication evidence (2)

- PubMed 16787399  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16787399/)
- PubMed 18817523  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18817523/)

## Tissue expression

**Tissue specificity (tau)**

0.766949

**Expression inequality (Gini)**

0.411554

### Highest expression

Expression in transcripts per million

**Artery - Tibial**

183.26

**Brain - Spinal cord (cervical c-1)**

180.68

**Artery - Coronary**

172.11

**Artery - Aorta**

165.92

**Brain - Frontal Cortex (BA9)**

76.47

### All tissues (54)

Expression in transcripts per million

- Artery - Tibial183.26
- Brain - Spinal cord (cervical c-1)180.68
- Artery - Coronary172.11
- Artery - Aorta165.92
- Brain - Frontal Cortex (BA9)76.47
- Nerve - Tibial74.63
- Brain - Hippocampus71.44
- Lung65.4
- Testis64.5
- Esophagus - Muscularis63.42
- Brain - Cortex61.01
- Muscle - Skeletal57.18
- Brain - Substantia nigra56.23
- Adipose - Subcutaneous56.21
- Esophagus - Gastroesophageal Junction52.7
- Thyroid50.18
- Brain - Caudate (basal ganglia)47.02
- Brain - Putamen (basal ganglia)45.33
- Brain - Anterior cingulate cortex (BA24)43.05
- Esophagus - Mucosa42.7
- Brain - Hypothalamus35.8
- Brain - Nucleus accumbens (basal ganglia)35.71
- Breast - Mammary Tissue35.16
- Uterus35.02
- Brain - Amygdala34.87

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (10)

- GO:0006893  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006893)
- GO:0006895  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006895)
- GO:0006897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006897)
- GO:0008333  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008333)
- GO:0014902  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014902)
- GO:0016050  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016050)
- GO:0032509  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032509)
- GO:0032868  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032868)
- GO:0048227  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048227)
- GO:0090160  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090160)

### Cellular components (11)

- GO:0005764  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764)
- GO:0005769  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005769)
- GO:0005794  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0005905  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005905)
- GO:0009986  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986)
- GO:0010008  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008)
- GO:0030136  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030136)
- GO:0031410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031410)
- GO:0048471  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471)

### Molecular functions (5)

- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0019899  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899)
- GO:0038024  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038024)
- GO:0048406  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048406)
- GO:1905394  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905394)

## Related records

### Trials (12)

- A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin (GRN) Mutation
- A Phase 2 Study to Evaluate AL001 in C9orf72-Associated ALS
- A Phase 2 Study to Evaluate Safety of Long-term AL001 Dosing in Frontotemporal Dementia (FTD) Patients (INFRONT-2)
- A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3)
- A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Healthy Adult Subjects
- A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Subjects With Bipolar I Disorder
- Continuation Study for Latozinemab
- Efficacy and Safety of AL-001 Ophthalmic Injection in Subjects with WAMD
- [Efficacy and Safety of GSK4527226 \[AL101\] in Participants With Early Alzheimer's Disease](https://trialight.com/data/trial/efficacy-and-safety-of-gsk4527226-al101-in-participants-with-64baf144-d28d-4a87-a22c-4adf272e1857.md)
- Multiple Ascending Dose Safety, Tolerability, PK Study of AL001 in Alzheimer's Disease Patients & Healthy Adult Subjects
- Open-label Extension Study in Participants With Early Alzheimer's Disease
- Safety and Tolerability of AL-001 Ophthalmic Injection in Subjects with WAMD

### Drugs (2)

- Latozinemab
- [Nivisnebart](https://trialight.com/data/asset/nivisnebart-24826803-d482-4174-b52d-6636b4a1c6d3.md)

---

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