> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/snca-968940e0-5926-55a8-b028-b20048e9b01f
> Record changed: 2026-11-04

# SNCA

ENSG00000145335

Target class

Unclassified protein

Chromosome

4

Approved drugs

0

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

0

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

SNCA

**Gene name**

Synuclein alpha

**Gene symbol**

SNCA

**Protein name**

Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)

### Other names (2)

- NACP
- PD1

### Previous gene symbols (2)

- PARK1
- PARK4

## Classification

**Gene biotype**

Protein coding

**Gene family**

Synuclein family

**Target class**

Unclassified protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

48

**Highest tissue expression**

106.1

**Tissue specificity (Gini)**

0.653

**Tissue specificity (tau)**

0.846

## Pathways and interactions

**KEGG gene identifiers**

- hsa:6622

**Protein interaction confidence**

0.844336

**Protein interaction partners**

119

### Reactome pathways (2)

- R-HSA-977225
- R-HSA-9833482

## Genomic location

**End position**

89838315

**Start position**

89700345

**Chromosome**

4

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000145335

**HGNC ID**

HGNC:11138

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11138)

**NCBI Gene ID**

6622

**UniProt ID**

P37840

## Cellular location

- Cytoplasm . Membrane . Nucleus . Synapse . Secreted . Cell projection, axon . Note=Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). .

### Publication evidence (8)

- PubMed 19762560  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19762560/)
- PubMed 24936070  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24936070/)
- PubMed 25561023  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25561023/)
- PubMed 26442590  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26442590/)
- PubMed 31034892  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/31034892/)
- PubMed 33657088  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33657088/)
- PubMed 12859192  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12859192/)
- PubMed 15282274  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15282274/)

## Tissue expression

**Tissue specificity (tau)**

0.846138

**Expression inequality (Gini)**

0.653461

### Highest expression

Expression in transcripts per million

**Brain - Cerebellar Hemisphere**

106.1

**Brain - Frontal Cortex (BA9)**

105.95

**Brain - Anterior cingulate cortex (BA24)**

75.04

**Brain - Cerebellum**

73.93

**Nerve - Tibial**

67

### All tissues (54)

Expression in transcripts per million

- Brain - Cerebellar Hemisphere106.1
- Brain - Frontal Cortex (BA9)105.95
- Brain - Anterior cingulate cortex (BA24)75.04
- Brain - Cerebellum73.93
- Nerve - Tibial67
- Brain - Cortex58.82
- Brain - Spinal cord (cervical c-1)42.6
- Brain - Amygdala38.25
- Brain - Nucleus accumbens (basal ganglia)34.51
- Brain - Substantia nigra34.12
- Whole Blood33.48
- Brain - Hypothalamus32.29
- Brain - Hippocampus30.33
- Brain - Caudate (basal ganglia)23.66
- Uterus21.09
- Brain - Putamen (basal ganglia)19.75
- Ovary13.68
- Pituitary13.09
- Cervix - Endocervix12.09
- Cervix - Ectocervix11.64
- Colon - Sigmoid11.43
- Vagina10.14
- Prostate7.36
- Lung7.01
- Esophagus - Gastroesophageal Junction6.91

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (47)

- GO:0000122  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122)
- GO:0001774  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001774)
- GO:0001921  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001921)
- GO:0006749  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006749)
- GO:0010040  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010040)
- GO:0010642  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010642)
- GO:0014059  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014059)
- GO:0016079  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016079)
- GO:0016082  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016082)
- GO:0031115  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031115)
- GO:0031623  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031623)
- GO:0031648  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031648)
- GO:0032026  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032026)
- GO:0032496  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032496)
- GO:0034341  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034341)
- GO:0034599  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034599)
- GO:0035493  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035493)
- GO:0035543  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035543)
- GO:0042416  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042416)
- GO:0043065  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043065)
- GO:0043066  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066)
- GO:0045807  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045807)
- GO:0045920  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045920)
- GO:0045921  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045921)
- GO:0050729  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050729)

And 22 more, listed on the interactive page.

### Cellular components (19)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005739  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739)
- GO:0005764  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0005938  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005938)
- GO:0015629  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015629)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)
- GO:0016234  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016234)
- GO:0030424  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030424)
- GO:0030426  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030426)
- GO:0031092  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031092)
- GO:0032991  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991)
- GO:0045202  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045202)
- GO:0048471  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471)
- GO:0097413  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097413)
- GO:0099512  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0099512)

### Molecular functions (31)

- GO:0000149  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000149)
- GO:0000287  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000287)
- GO:0000976  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000976)
- GO:0003779  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003779)
- GO:0004857  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004857)
- GO:0004860  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004860)
- GO:0004869  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004869)
- GO:0005504  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005504)
- GO:0005507  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005507)
- GO:0005509  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005509)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0005543  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005543)
- GO:0008047  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008047)
- GO:0008198  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008198)
- GO:0008270  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008270)
- GO:0008289  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008289)
- GO:0015631  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015631)
- GO:0016491  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016491)
- GO:0019894  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019894)
- GO:0019899  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899)
- GO:0030544  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030544)
- GO:0042393  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042393)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)
- GO:0043014  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043014)
- GO:0048156  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048156)

And 6 more, listed on the interactive page.

## Related records

### Trials (9)

- A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Japanese Participants With Parkinson's Disease
- [A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-and-safety-of-intravenous-1269a3d8-2519-4b21-a6fc-86cf80a4f5c4.md)
- A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease
- A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease
- Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Participants With Parkinson's Disease
- Multiple Ascending Dose Study of PRX002 in Patients With Parkinson's Disease
- Prevent Cognitive Decline in GBA-associated Parkinson's Disease
- Single Ascending Dose Study of PRX002 in Healthy Subjects
- Single-Ascending Dose Study of BIIB054 in Healthy Participants and Early Parkinson's Disease

### Drugs (2)

- Cinpanemab Alpha-synuclein inhibitor
- [Prasinezumab](https://trialight.com/data/asset/prasinezumab-2fbef4fa-88bd-4067-a69d-0bceaec155a4.md) Alpha-synuclein binding agent

---

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