> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/snap25-e20d078e-05a8-52d9-9d9c-935072556a8c
> Record changed: 2026-10-13

# SNAP25

ENSG00000132639

Target class

Other cytosolic protein

Chromosome

20

Approved drugs

7

Clinical candidates (approved and in development)

8

## Clinical evidence

**Approved drugs**

7

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

8

## Druggability

**Chemical probe available**

No

## Names

**Target name**

SNAP25

**Gene name**

Synaptosome associated protein 25

**Gene symbol**

SNAP25

**Previous gene symbols**

- SNAP

**Protein name**

Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein)

### Other names (6)

- SNAP-25
- RIC-4
- RIC4
- SEC9
- bA416N4.2
- dJ1068F16.2

## Classification

**Gene biotype**

Protein coding

**Gene family**

SNAREs

**Target class**

Other cytosolic protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

41

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

3,165.59

**Tissue specificity (Gini)**

0.867

**Tissue specificity (tau)**

0.954

## Pathways and interactions

**KEGG gene identifiers**

- hsa:6616

**Protein interaction confidence**

0.859259

**Protein interaction partners**

108

### Reactome pathways (13)

- R-HSA-181429
- R-HSA-181430
- R-HSA-210500
- R-HSA-212676
- R-HSA-264642
- R-HSA-422356
- R-HSA-449836
- R-HSA-5250968
- R-HSA-5250971
- R-HSA-5250992
- R-HSA-6798695
- R-HSA-888590
- R-HSA-9662360

## Genomic location

**End position**

10308258

**Start position**

10172395

**Chromosome**

20

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000132639

**HGNC ID**

HGNC:11132

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11132)

**NCBI Gene ID**

6616

**UniProt ID**

P60880

## Cellular location

- Cytoplasm, perinuclear region . Cell membrane
- Lipid-anchor . Synapse, synaptosome . Photoreceptor inner segment . Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. Colocalizes with KCNB1 at the cell membrane (By similarity). Colocalizes with PLCL1 at the cell membrane (By similarity). .
- Plasma membrane
- Vesicles

## Tissue expression

**Tissue specificity (tau)**

0.954189

**Expression inequality (Gini)**

0.866982

### Highest expression

Expression in transcripts per million

**Brain - Cerebellar Hemisphere**

3,165.59

**Brain - Frontal Cortex (BA9)**

1,829.19

**Brain - Cerebellum**

1,587.14

**Brain - Anterior cingulate cortex (BA24)**

792.62

**Brain - Cortex**

685.1

### All tissues (54)

Expression in transcripts per million

- Brain - Cerebellar Hemisphere3,165.59
- Brain - Frontal Cortex (BA9)1,829.19
- Brain - Cerebellum1,587.14
- Brain - Anterior cingulate cortex (BA24)792.62
- Brain - Cortex685.1
- Brain - Amygdala475.26
- Brain - Hippocampus473.46
- Brain - Nucleus accumbens (basal ganglia)438.94
- Brain - Caudate (basal ganglia)379.13
- Brain - Hypothalamus286.03
- Brain - Putamen (basal ganglia)258.59
- Brain - Substantia nigra160.67
- Pituitary111.07
- Brain - Spinal cord (cervical c-1)73.32
- Fallopian Tube20.04
- Ovary19.2
- Uterus15.24
- Artery - Aorta9.41
- Prostate8.46
- Testis8.08
- Colon - Sigmoid6.13
- Artery - Tibial5.12
- Adrenal Gland3.63
- Artery - Coronary3.12
- Lung2.87

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (3)

- GO:0006906  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006906)
- GO:0016079  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016079)
- GO:0050796  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050796)

### Cellular components (10)

- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005856  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005856)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0031083  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031083)
- GO:0031201  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031201)
- GO:0031982  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031982)
- GO:0035579  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035579)
- GO:0042734  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042734)
- GO:0070821  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070821)

### Molecular functions (3)

- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008289  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008289)
- GO:0017075  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017075)

## Related records

### Trials (1,072)

- " Treating MS Patients With Lower Extremity Spasticity Using Dysport"
- "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"
- (Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist
- A Clinical Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in The Treatment of Upper Limb Spasticity in Adults
- A Clinical Trial to Evaluate a Recombinant Staphylococcus Aureus Vaccine (Escherichia Coli) in Healthy Adults
- A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
- A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine
- A Clinical Trial to Investigate Efficacy and Safety of NT 201 Injections Compared With Placebo Injections in Participants Aged 18 Years and Older With Chronic Nerve Pain After Shingles or Nerve Injury
- A Comparative Study of Botulinum Neurotoxin Type A in Treatment of Moderate to Severe Glabellar Frown Lines
- A Comparative Study on the Impact of Trigger Points Injection of Platelet Rich Plasma Versus Botulinum Toxin on the Relief of Jaw Muscles Myofascial Pain
- A Comparative Study to Evaluate the Effects and Mechanism of Action of Dysport®, Botox® and Xeomin® in the Extensor Digitorum Brevis Model in Healthy Adult Male Participants
- A Comparison Study of Oxybutynin and Botulinum Toxin for Neurogenic Detrusor Overactivity
- A Dosage-dependent Manner of Botulinum Toxin Type A on the Prevention of Postoperative Scars of Various Anatomic Regions of the Body
- A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic Clubfoot
- A Double-Blinded, Randomized Placebo Controlled Pilot Study Comparing the Efficacy and Safety of IncobotulinumtoxinA Versus Saline Injections to the Cheek Region in Patients With Rosacea
- A Long-term Efficacy, Safety, and Tolerability Study of BOTOX® in Patients With Chronic Migraine
- A Long-Term Extension Study of OnabotulinumtoxinA (BOTOX®) for Urinary Incontinence Due to Neurogenic Detrusor Overactivity
- A Long-term Follow-up Study of Botulinum Toxin Type A in Patients With Overactive Bladder as a Result of Spinal Injury or Multiple Sclerosis
- A Long-Term Safety Study of Repeat Treatment With PurTox® for Frown Lines Between the Eyebrows
- A Multi-Center Study Of CD07743 for the Improvement of Lateral Canthal Lines (CROW'S FEET)

### Drugs (8)

- Abobotulinumtoxina Synaptosomal nerve-associated protein 25 (SNAP-25) inhibitor
- [Botulinum toxin type A](https://trialight.com/data/asset/botulinum-toxin-type-a-5a0f3130-910b-4917-87ef-65a743f12642.md) Synaptosomal nerve-associated protein 25 (SNAP-25) hydrolytic enzyme
- Daxibotulinumtoxina Synaptosomal nerve-associated protein 25 (SNAP-25) inhibitor
- Incobotulinumtoxina Synaptosomal nerve-associated protein 25 (SNAP-25) inhibitor
- Letibotulinumtoxina Synaptosomal nerve-associated protein 25 (SNAP-25) hydrolytic enzyme
- Onabotulinumtoxina Synaptosomal nerve-associated protein 25 (SNAP-25) inhibitor
- Prabotulinumtoxin A Synaptosomal nerve-associated protein 25 (SNAP-25) proteolytic enzyme
- Trenibotulinumtoxine Synaptosomal nerve-associated protein 25 (SNAP-25) hydrolytic enzyme

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