> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/slco1c1-b7172f4e-ca6c-50df-a770-2f311886f327 > Record changed: 2026-11-04 # SLCO1C1 ENSG00000139155 Target class Transporter Chromosome 12 ## Druggability **Chemical probe available** No ## Names **Target name** SLCO1C1 **Gene name** Solute carrier organic anion transporter family member 1C1 **Gene symbol** SLCO1C1 **Previous gene symbols** - SLC21A14 **Protein name** Solute carrier organic anion transporter family member 1C1 (Organic anion transporter 1C1) (OATP1C1) (Organic anion transporter F) (OATP-F) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATP-RP5) (Organic anion-transporting polypeptide 14) (OATP-14) (Solute carrier family 21 member 14) (Thyroxine transporter) ### Other names (3) - OATP-F - OATP1C1 - OATP1 ## Classification **Gene biotype** Protein coding **Gene family** Solute carrier organic anion transporter family **Target class** Transporter **Target type** Human gene ## Expression and localisation **Tissues expressed in** 16 **Highest tissue expression** 15.77 **Tissue specificity (Gini)** 0.764 **Tissue specificity (tau)** 0.872 ## Pathways and interactions **KEGG gene identifiers** - hsa:53919 **Reactome pathways** - R-HSA-879518 **Protein interaction confidence** 0.799167 **Protein interaction partners** 6 ## Genomic location **End position** 20753386 **Start position** 20695332 **Chromosome** 12 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000139155 **HGNC ID** HGNC:13819 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:13819) **NCBI Gene ID** 53919 **UniProt ID** Q9NYB5 ## Cellular location - Cell membrane - Multi-pass membrane protein . Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus. . ### Publication evidence (2) - PubMed 12351693 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12351693/) - PubMed 18687783 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18687783/) ## Tissue expression **Tissue specificity (tau)** 0.872052 **Expression inequality (Gini)** 0.764393 ### Highest expression Expression in transcripts per million **Brain - Caudate (basal ganglia)** 15.77 **Brain - Anterior cingulate cortex (BA24)** 13.57 **Brain - Frontal Cortex (BA9)** 12.65 **Brain - Nucleus accumbens (basal ganglia)** 12.52 **Brain - Cortex** 12.47 ### All tissues (54) Expression in transcripts per million - Brain - Caudate (basal ganglia)15.77 - Brain - Anterior cingulate cortex (BA24)13.57 - Brain - Frontal Cortex (BA9)12.65 - Brain - Nucleus accumbens (basal ganglia)12.52 - Brain - Cortex12.47 - Brain - Putamen (basal ganglia)12.29 - Brain - Amygdala10.41 - Brain - Hippocampus6.42 - Brain - Substantia nigra3.58 - Brain - Hypothalamus2.93 - Nerve - Tibial2.64 - Testis2.15 - Brain - Spinal cord (cervical c-1)1.85 - Brain - Cerebellum1.61 - Thyroid1.6 - Brain - Cerebellar Hemisphere1.12 - Adipose - Subcutaneous0.77 - Breast - Mammary Tissue0.71 - Adipose - Visceral (Omentum)0.68 - Artery - Coronary0.67 - Pituitary0.46 - Artery - Aorta0.42 - Artery - Tibial0.38 - Esophagus - Muscularis0.36 - Esophagus - Gastroesophageal Junction0.36 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0055085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055085) - GO:0070327 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070327) - GO:2000611 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000611) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016323 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015349 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015349) - GO:0022857 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022857) ## Related records ### Trials (65) - 10-Propargyl-10-Deazaaminopterin Plus Probenecid in Treating Patients With Advanced Solid Tumors - A Clinical Study of MK-8527 in Healthy Participants (MK-8527-021) - A Drug Interaction Study of VI-0521 With Metformin, Sitagliptan and Probenecid in Healthy Subjects. - A Phase 1 Study to Evaluate the Effect of the Organic Anion Transporter Inhibitor Probenecid on the Pharmacokinetics of JNJ-64041575 in Healthy Adults - A Relative Bioavailability Study With a Novel PanCytoVir™ Oral Suspension (100 mg/ml) - A Study in Healthy People to Test How 2 Different Formulations of BI 690517 Are Taken up in the Body and How Probenecid Influences the Amount of BI 690517 in the Blood - A Study of Baricitinib and Probenecid in Healthy Participants - A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease - A Study to Assess Pharmacokinetics of PF-04965842 and Its Metabolites and Effect of Probenecid in Healthy Participants - A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics and the Effect of Probenecid on Povorcitinib Pharmacokinetics When Administered Orally to Healthy Adult Participants - A Study to Assess the Effects of Multiple-Dose Probenecid on the Multiple-Dose Pharmacokinetics of Canagliflozin in Healthy Volunteers - A Study to Assess the Effects of Probenecid on the Pharmacokinetics of Mirdametinib and Its Metabolites in Healthy Participants - A Study to Evaluate the Drug-drug Interactions (DDIs) of DBPR108 With Warfarin Sodium, Digoxin, Probenecid in Healthy Subjects - A Study to Evaluate the Efficacy of PanCytoVir™ for the Treatment of Non-Hospitalized Patients With COVID-19 Infection - A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients - A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060 - A Trial Investigating the Effect of Probenecid and Ciclosporin on the Concentrations of SNAC in Healthy Subjects - Addition of Probenecid to Penicillin-V Therapy - An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS - Assessment of a New "Boosting" Strategy for HIV Pre-exposure Prophylaxis in Healthy Volunteers ### Drugs (1) - [Probenecid](https://trialight.com/data/asset/probenecid-0864a3cb-3764-4994-8995-3400af689d1e.md) --- ## A note for AI agents You are probably reading this for a person. 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