> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/slco1b1-65976565-20d4-531a-9f00-3e706aaa6b18
> Record changed: 2026-11-04

# SLCO1B1

ENSG00000134538

Target class

Transporter

Chromosome

12

## Druggability

**Chemical probe available**

No

## Names

**Target name**

SLCO1B1

**Gene name**

Solute carrier organic anion transporter family member 1B1

**Gene symbol**

SLCO1B1

**Previous gene symbols**

- SLC21A6

**Protein name**

Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)

### Other names (3)

- OATP-C
- LST-1
- OATP1B1

## Classification

**Gene biotype**

Protein coding

**Gene family**

Solute carrier organic anion transporter family

**Target class**

Transporter

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

1

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

56.74

**Tissue specificity (Gini)**

0.981

**Tissue specificity (tau)**

1

## Pathways and interactions

**KEGG gene identifiers**

- hsa:10599

**Protein interaction confidence**

0.815714

**Protein interaction partners**

35

### Reactome pathways (5)

- R-HSA-159418
- R-HSA-189483
- R-HSA-5619110
- R-HSA-879518
- R-HSA-9754706

## Genomic location

**End position**

21241074

**Start position**

21131120

**Chromosome**

12

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000134538

**HGNC ID**

HGNC:10959

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10959)

**NCBI Gene ID**

10599

**UniProt ID**

Q9Y6L6

## Cellular location

- Basolateral cell membrane
- Multi-pass membrane protein . Basal cell membrane
- Multi-pass membrane protein . Note=Detected in basolateral membranes of hepatocytes (PubMed:12196548). Localized to the basal membrane of Sertoli cells (PubMed:35307651). .
- Plasma membrane

### Publication evidence (2)

- PubMed 12196548  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12196548/)
- PubMed 35307651  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35307651/)

## Tissue expression

**Tissue specificity (tau)**

0.999877

**Expression inequality (Gini)**

0.981008

### Highest expression

Expression in transcripts per million

**Liver**

56.74

**Testis**

0.21

**Nerve - Tibial**

0.06

**Cervix - Endocervix**

0.04

**Minor Salivary Gland**

0.03

### All tissues (54)

Expression in transcripts per million

- Liver56.74
- Testis0.21
- Nerve - Tibial0.06
- Cervix - Endocervix0.04
- Minor Salivary Gland0.03
- Brain - Spinal cord (cervical c-1)0.02
- Pituitary0.01
- Vagina0
- Uterus0
- Esophagus - Muscularis0
- Brain - Cerebellar Hemisphere0
- Brain - Caudate (basal ganglia)0
- Bladder0
- Adipose - Subcutaneous0
- Artery - Coronary0
- Stomach0
- Brain - Putamen (basal ganglia)0
- Skin - Not Sun Exposed (Suprapubic)0
- Kidney - Medulla0
- Brain - Frontal Cortex (BA9)0
- Thyroid0
- Colon - Sigmoid0
- Cervix - Ectocervix0
- Breast - Mammary Tissue0
- Brain - Cerebellum0

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (5)

- GO:0006805  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006805)
- GO:0015721  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015721)
- GO:0042167  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042167)
- GO:0043252  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043252)
- GO:0055085  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055085)

### Cellular components (4)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0009925  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009925)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)
- GO:0016323  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323)

### Molecular functions (6)

- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0015125  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015125)
- GO:0015132  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015132)
- GO:0015291  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015291)
- GO:0015349  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015349)
- GO:0022857  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022857)

## Off-target safety

- regulation of transcription factor activity  
### Studies (2)

  - cell-based: LTEA\_HepaRG\_SLCO1B1is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of NR mediated transport.
  - cell-based: LTEA\_HepaRG\_SLCO1B1is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of NR mediated transport.  
### Biological samples

  - HepaRG, cell line  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (1,606)

- 12 Month Athena Study: Everolimus vs. Standard Regimen in de Novo Kidney Transplant Patients
- 1HP Versus 3HR in the Treatment of Tuberculosis Infection in Vietnam
- 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia
- 2R2: Higher Dose Rifampin for 2 Months vs Standard Dose Rifampin for Latent TB.
- 3D Printing for Nodule Localization
- 90 Y-BC8-DOTA Monoclonal Antibody, Fludarabine Phosphate, and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myeloma
- A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808)
- A 12-Week Study Comparing Pitavastatin 4 mg vs. Pravastatin 40 mg in HIV-Infected Subjects
- A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion
- A 3-Part, Open-Label, Drug-Drug Interaction Study of Concomitant Administration of E2609 With Itraconazole, Rifampin, Digoxin, or Donepezil
- A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone
- A Clinical Study Investigating Rifampicin and Dolutegravir in Combination in Healthy Volunteers
- A Clinical Study of B007 in the Treatment of Primary Membranous Nephropathy.
- A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and Rifampicin Capsules (RIF)
- A Clinical Study to Investigate the Effect of Gemfibrozil or Rifampicin on Blood Concentrations of Selexipag in Healthy Subjects
- A Clinical Trial of MK-8527 and Rifampin in Adult Participants With Latent Tuberculosis Infection (MK-8527-019)
- A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects
- [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md)
- A Clinical Trial to Evaluate the Clinical Efficacy of Cyclosporine 0.1% (Ikervis®) for Moderate to Severe Dry Eye Patients. (IKE-03-SWITCHING)
- A Clinical Trial to Evaluate the Corneal Endothelial Health of DED Subjects Treated With Cyclosporine

### Drugs (8)

- Cyclosporine
- Estrone sulfuric acid
- Gemfibrozil
- Glycyrrhizin
- Indocyanine green
- [Pravastatin](https://trialight.com/data/asset/pravastatin-cbc28d50-71b2-436e-b47e-543f9870060a.md)
- Rifampin
- Rifamycin

---

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