> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/slc6a9-f614fb23-90ed-5ab5-9c4c-00f1c38c2338 > Record changed: 2026-11-04 # SLC6A9 ENSG00000196517 Target class Transporter Chromosome 1 Approved drugs 0 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 0 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Target name** SLC6A9 **Gene name** Solute carrier family 6 member 9 **Gene symbol** SLC6A9 **Protein name** Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) ### Other names (2) - GLYT1 - GlyT-1 ## Classification **Gene biotype** Protein coding **Gene family** Solute carrier family 6 **Target class** Transporter **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Protein localisation evidence grade** Approved **Highest tissue expression** 70.3 **Tissue specificity (Gini)** 0.525 **Tissue specificity (tau)** 0.865 ## Pathways and interactions **KEGG gene identifiers** - hsa:6536 **Reactome pathways** - R-HSA-442660 **Protein interaction confidence** 0.896 **Protein interaction partners** 1 ## Genomic location **End position** 44031467 **Start position** 43991500 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000196517 **HGNC ID** HGNC:11056 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11056) **NCBI Gene ID** 6536 **UniProt ID** P48067 ## Cellular location - Cell membrane - Multi-pass membrane protein . - Golgi apparatus - Nucleoplasm ## Tissue expression **Tissue specificity (tau)** 0.865351 **Expression inequality (Gini)** 0.525291 ### Highest expression Expression in transcripts per million **Brain - Spinal cord (cervical c-1)** 70.3 **Skin - Sun Exposed (Lower leg)** 58.65 **Skin - Not Sun Exposed (Suprapubic)** 49.24 **Vagina** 24.47 **Brain - Substantia nigra** 24.25 ### All tissues (54) Expression in transcripts per million - Brain - Spinal cord (cervical c-1)70.3 - Skin - Sun Exposed (Lower leg)58.65 - Skin - Not Sun Exposed (Suprapubic)49.24 - Vagina24.47 - Brain - Substantia nigra24.25 - Esophagus - Mucosa23.04 - Adrenal Gland21.88 - Lung16.14 - Fallopian Tube16.06 - Uterus15.41 - Brain - Hypothalamus14 - Cervix - Endocervix11.39 - Colon - Transverse11.11 - Colon - Sigmoid10.64 - Cervix - Ectocervix10.62 - Bladder10.43 - Brain - Hippocampus9.34 - Minor Salivary Gland9.05 - Brain - Cerebellum8.8 - Esophagus - Muscularis8.79 - Brain - Nucleus accumbens (basal ganglia)8.69 - Brain - Caudate (basal ganglia)8.12 - Artery - Aorta7.86 - Thyroid7.6 - Esophagus - Gastroesophageal Junction7.44 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0006836 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006836) - GO:1903804 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903804) ### Cellular components (6) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009925) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0016323 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) - GO:0016328 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016328) ### Molecular functions (2) - GO:0015187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015187) - GO:0015375 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015375) ## Related records ### Trials (65) - A Pharmacodynamic and Pharmacokinetic Study of RO4917838 in Healthy Volunteers - A Pharmacokinetic Study of RO4917838 in Healthy Chinese Volunteers - A Study Exmining the Effect of Multiple Doses of Bitopertin on the Single Dose Pharmacokinetics of Midazolam in Healthy Volunteers. - A Study in Healthy Men and Women to Test Which Effects Donepezil and BI 425809 Have on Each Other - A Study in Healthy Men and Women to Test Which Effects Memantine and BI 425809 Have on Each Other - A Study in Healthy Men to Find Out How BI 425809 is Taken up and Handled by the Body - A Study in Healthy Men to Measure the Amount of BI 425809 in the Blood When Taken as a Tablet - A Study in Healthy Men to Test How Fluconazole Influences the Amount of BI 425809 in the Blood - A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine - A Study in Healthy Men to Test Whether BI 425809 Influences the Amount of Midazolam in the Blood - A Study in Healthy Men to Test Whether Bosentan Influences the Amount of BI 425809 in the Blood - A Study in Healthy Men to Test Whether Rifampicin Influences the Amount of BI 425809 in the Blood - A Study in Healthy People to Test How BI 425809 is Taken up in the Body When Taken With or Without Food - A Study in Healthy People to Test if Taking Different Formulations of BI 425809 Tablets Influences the Amount of BI 425809 in the Blood - A Study in Healthy People to Test Whether Iclepertin Has an Effect on Cardiac Safety - A Study in Healthy Women to Test Whether BI 425809 Influences the Amount of a Contraceptive in the Blood - A Study Of Adjunctive Treatment Of Cognitive Deficits In Schizophrenia - A Study of Bitopertin (RO4917838) in Adults With Non-Transfusion-Dependent (NTD) Beta-Thalassemia - A Study of Bitopertin (RO4917838) in Combination With Selective Serotonin Reuptake Inhibitors (SSRIs) in Participants With Obsessive-Compulsive Disorder (OCD) - A Study of Bitopertin (RO4917838) in Healthy Male Volunteers ### Drugs (5) - Bitopertin Glycine transporter 1 inhibitor - [Iclepertin](https://trialight.com/data/asset/iclepertin-4c0281d8-fbd3-472f-97e8-f7007cb50348.md) - LY-2365109 - ORG-25935 Glycine transporter 1 inhibitor - PF-03463275 Glycine transporter 1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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