SLC6A9
ENSG00000196517
Target class
Transporter
Chromosome
1
Approved drugs
0
Clinical candidates (approved and in development)
3
- Approved drugs
- 0
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 3
- Chemical probe available
- Yes
- Target name
- SLC6A9
- Gene name
- Solute carrier family 6 member 9
- Gene symbol
- SLC6A9
- Protein name
- Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9)
- GLYT1
- GlyT-1
- Gene biotype
- Protein coding
- Gene family
- Solute carrier family 6
- Target class
- Transporter
- Target type
- Human gene
- Tissues expressed in
- 51
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 70.3
- Tissue specificity (Gini)
- 0.525
- Tissue specificity (tau)
- 0.865
- KEGG gene identifiers
- hsa:6536
- Reactome pathways
- R-HSA-442660
- Protein interaction confidence
- 0.896
- Protein interaction partners
- 1
- End position
- 44031467
- Start position
- 43991500
- Chromosome
- 1
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein .
- Golgi apparatus
- Nucleoplasm
- Tissue specificity (tau)
- 0.865351
- Expression inequality (Gini)
- 0.525291
Expression in transcripts per million
- Brain - Spinal cord (cervical c-1)
- 70.3
- Skin - Sun Exposed (Lower leg)
- 58.65
- Skin - Not Sun Exposed (Suprapubic)
- 49.24
- Vagina
- 24.47
- Brain - Substantia nigra
- 24.25
Expression in transcripts per million
- Brain - Spinal cord (cervical c-1)70.3
- Skin - Sun Exposed (Lower leg)58.65
- Skin - Not Sun Exposed (Suprapubic)49.24
- Vagina24.47
- Brain - Substantia nigra24.25
- Esophagus - Mucosa23.04
- Adrenal Gland21.88
- Lung16.14
- Fallopian Tube16.06
- Uterus15.41
- Brain - Hypothalamus14
- Cervix - Endocervix11.39
- Colon - Transverse11.11
- Colon - Sigmoid10.64
- Cervix - Ectocervix10.62
- Bladder10.43
- Brain - Hippocampus9.34
- Minor Salivary Gland9.05
- Brain - Cerebellum8.8
- Esophagus - Muscularis8.79
- Brain - Nucleus accumbens (basal ganglia)8.69
- Brain - Caudate (basal ganglia)8.12
- Artery - Aorta7.86
- Thyroid7.6
- Esophagus - Gastroesophageal Junction7.44
And 29 more, listed on the interactive page.
- GO:0006836
- GO:1903804
- GO:0005886
- GO:0009925
- GO:0016020
- GO:0016323
- GO:0016324
- GO:0016328
- GO:0015187
- GO:0015375
Related records
Trials (65)
- A Pharmacodynamic and Pharmacokinetic Study of RO4917838 in Healthy Volunteers
- A Pharmacokinetic Study of RO4917838 in Healthy Chinese Volunteers
- A Study Exmining the Effect of Multiple Doses of Bitopertin on the Single Dose Pharmacokinetics of Midazolam in Healthy Volunteers.
- A Study in Healthy Men and Women to Test Which Effects Donepezil and BI 425809 Have on Each Other
- A Study in Healthy Men and Women to Test Which Effects Memantine and BI 425809 Have on Each Other
- A Study in Healthy Men to Find Out How BI 425809 is Taken up and Handled by the Body
- A Study in Healthy Men to Measure the Amount of BI 425809 in the Blood When Taken as a Tablet
- A Study in Healthy Men to Test How Fluconazole Influences the Amount of BI 425809 in the Blood
- A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine
- A Study in Healthy Men to Test Whether BI 425809 Influences the Amount of Midazolam in the Blood
- A Study in Healthy Men to Test Whether Bosentan Influences the Amount of BI 425809 in the Blood
- A Study in Healthy Men to Test Whether Rifampicin Influences the Amount of BI 425809 in the Blood
- A Study in Healthy People to Test How BI 425809 is Taken up in the Body When Taken With or Without Food
- A Study in Healthy People to Test if Taking Different Formulations of BI 425809 Tablets Influences the Amount of BI 425809 in the Blood
- A Study in Healthy People to Test Whether Iclepertin Has an Effect on Cardiac Safety
- A Study in Healthy Women to Test Whether BI 425809 Influences the Amount of a Contraceptive in the Blood
- A Study Of Adjunctive Treatment Of Cognitive Deficits In Schizophrenia
- A Study of Bitopertin (RO4917838) in Adults With Non-Transfusion-Dependent (NTD) Beta-Thalassemia
- A Study of Bitopertin (RO4917838) in Combination With Selective Serotonin Reuptake Inhibitors (SSRIs) in Participants With Obsessive-Compulsive Disorder (OCD)
- A Study of Bitopertin (RO4917838) in Healthy Male Volunteers
Drugs (5)
- Bitopertin Glycine transporter 1 inhibitor
- Iclepertin
- LY-2365109
- ORG-25935 Glycine transporter 1 inhibitor
- PF-03463275 Glycine transporter 1 inhibitor