> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/slc6a4-84e5ed20-84c3-553b-a5e4-897663516251
> Record changed: 2026-10-13

# SLC6A4

ENSG00000108576

Target class

Transporter

Chromosome

17

Approved drugs

32

Clinical candidates (approved and in development)

45

## Clinical evidence

**Approved drugs**

32

**ClinGen gene-disease validity**

Disputed

**Clinical candidates (approved and in development)**

45

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

SLC6A4

**Gene name**

Solute carrier family 6 member 4

**Gene symbol**

SLC6A4

**Protein name**

Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4)

### Other names (2)

- 5-HTT
- SERT1

### Previous gene symbols (2)

- HTT
- OCD1

## Classification

**Gene biotype**

Protein coding

**Gene family**

Solute carrier family 6

**Target class**

Transporter

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

4

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

35.74

**Tissue specificity (Gini)**

0.833

**Tissue specificity (tau)**

0.99

## Pathways and interactions

**KEGG gene identifiers**

- hsa:6532

**Protein interaction confidence**

0.838

**Protein interaction partners**

31

### Reactome pathways (2)

- R-HSA-380615
- R-HSA-442660

## Genomic location

**End position**

30238482

**Start position**

30194312

**Chromosome**

17

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000108576

**HGNC ID**

HGNC:11050

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11050)

**NCBI Gene ID**

6532

**UniProt ID**

P31645

## Cellular location

- Cell membrane
- Multi-pass membrane protein . Endomembrane system
- Multi-pass membrane protein . Endosome membrane
- Multi-pass membrane protein . Synapse . Cell junction, focal adhesion . Cell projection, neuron projection . Note=Could be part of recycling endosomes (PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity). .
- Golgi apparatus
- Vesicles

### Publication evidence (4)

- PubMed 12869649  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12869649/)
- PubMed 16870614  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16870614/)
- PubMed 17506858  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17506858/)
- PubMed 27049939  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27049939/)

## Tissue expression

**Tissue specificity (tau)**

0.99016

**Expression inequality (Gini)**

0.832727

### Highest expression

Expression in transcripts per million

**Lung**

35.74

**Small Intestine - Terminal Ileum**

4.22

**Cells - EBV-transformed lymphocytes**

1.78

**Esophagus - Mucosa**

1.65

**Nerve - Tibial**

0.73

### All tissues (54)

Expression in transcripts per million

- Lung35.74
- Small Intestine - Terminal Ileum4.22
- Cells - EBV-transformed lymphocytes1.78
- Esophagus - Mucosa1.65
- Nerve - Tibial0.73
- Testis0.69
- Skin - Sun Exposed (Lower leg)0.68
- Artery - Aorta0.57
- Skin - Not Sun Exposed (Suprapubic)0.53
- Brain - Cerebellar Hemisphere0.45
- Heart - Atrial Appendage0.38
- Brain - Cerebellum0.38
- Vagina0.37
- Fallopian Tube0.31
- Thyroid0.3
- Breast - Mammary Tissue0.28
- Adipose - Subcutaneous0.28
- Spleen0.25
- Adipose - Visceral (Omentum)0.23
- Artery - Coronary0.23
- Esophagus - Gastroesophageal Junction0.23
- Esophagus - Muscularis0.21
- Kidney - Cortex0.21
- Colon - Transverse0.2
- Kidney - Medulla0.19

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (4)

- GO:0006836  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006836)
- GO:0009636  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009636)
- GO:0051610  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051610)
- GO:0090067  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090067)

### Cellular components (5)

- GO:0005794  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0010008  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008)
- GO:0012505  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0012505)
- GO:0045121  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121)

### Molecular functions (7)

- GO:0005178  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178)
- GO:0005335  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005335)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008504  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008504)
- GO:0015297  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015297)
- GO:0031402  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031402)
- GO:0051378  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051378)

## On-target safety

- nausea and vomiting  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: nausea and vomiting  
### Biological samples (3)

  - cardiovascular system
  - nervous system
  - gastrointestinal  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- insomnia  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: insomnia  
### Biological samples (3)

  - cardiovascular system
  - nervous system
  - gastrointestinal  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- pulmonary hypertension  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: pulmonary hypertension  
### Biological samples (4)

  - central nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- Decrease, Population growth rate  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/203)
- gastrointestinal cramps  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: gastrointestinal cramps  
### Biological samples (3)

  - cardiovascular system
  - nervous system
  - gastrointestinal  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- dizziness  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: dizziness  
### Biological samples (4)

  - central nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- Decreased, Reproductive Success  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/203)
- decreased/increased anxiety  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased/increased anxiety  
### Biological samples (4)

  - central nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- sexual dysfunction  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: sexual dysfunction  
### Biological samples (3)

  - cardiovascular system
  - nervous system
  - gastrointestinal  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- diarrhea  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: diarrhea  
### Biological samples (4)

  - central nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased/increased locomotor activity  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased/increased locomotor activity  
### Biological samples (4)

  - central nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased eating  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased eating  
### Biological samples (4)

  - central nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- nausea  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: nausea  
### Biological samples (4)

  - central nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- Increased, Reproductive Success  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/204)
- decreased platelet aggregation  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased platelet aggregation  
### Biological samples (4)

  - central nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- Increase, predation  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/97)
- Increased, predation  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/98)
- dry mouth  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: dry mouth  
### Biological samples (4)

  - central nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- primary pulmonary hypertension  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: primary pulmonary hypertension  
### Biological samples (3)

  - cardiovascular system
  - nervous system
  - gastrointestinal  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- Decrease, Population growth rate  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/97)
- decreased body weight  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased body weight  
### Biological samples (4)

  - central nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- valvular heart disease  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: valvular heart disease  
### Biological samples (3)

  - cardiovascular system
  - nervous system
  - gastrointestinal  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- anxiety  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: anxiety  
### Biological samples (3)

  - cardiovascular system
  - nervous system
  - gastrointestinal  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- diarrhea  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: diarrhea  
### Biological samples (3)

  - cardiovascular system
  - nervous system
  - gastrointestinal  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- decreased appetite  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased appetite  
### Biological samples (4)

  - central nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

And 8 more, listed on the interactive page.

## Off-target safety

- increased gastrointestinal motility  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased gastrointestinal motility  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- decreased upper gastrointestinal transit  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: decreased upper gastrointestinal transit  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- insomnia  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: insomnia  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- increased other serotonin-mediated effects  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased other serotonin-mediated effects  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- sexual dysfunction  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: sexual dysfunction  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- nausea  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: nausea  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- decreased plasma renin  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: decreased plasma renin  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- anxiety  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: anxiety  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- receptor binding  
### Studies

  - biochemical: NVS\_TR\_hSERT, is one of one assay component(s) measured or calculated from the NVS\_TR\_hSERT assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology.  
### Biological samples

  - vascular, tissue-based cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (2,158)

- 'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug
- "Evaluation by Transcranial Magnetic Stimulation of the Benefit of Fluoxetine on Motor Recovery After Stroke"
- "MILNACIPRAN" in Subjects With Chronic Shoulder Pain
- 12-Week Study of Pristiq (Desvenlafaxine) Social Anxiety Disorder
- 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
- 24-Week Efficacy & Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms
- 48 Weeks, Study to Evaluate Overall Safety and Tolerability of Co-administration of Tesofensine and Metoprolol in Subjects With Hypothalamic Injury-induced Obesity (HIO)
- 6-week Study Treatment to Evaluate the Safety and Effectiveness of AZD2066 in Patients With Major Depressive Disorder
- 7T Amygdala and Citalopram Study
- 90 mg Fluoxetine Hydrochloride Capsules Under Fasting Conditions
- 90 mg Fluoxetine Hydrochloride Capsules Under Non-Fasting Conditions
- A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder (3)
- A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (1)
- A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2)
- A 10-Week, Open-Label, Flexible Dose Adaptive Study Evaluating the Efficacy of Vortioxetine in Subjects With Panic Disorder
- A 52-Week Study of Bicifadine in Patients With Chronic Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
- A 6 Week Study to Determine the Effectiveness of R228060 in Adult Subjects With Major Depressive Disorder
- A Bioequivalence Study of the Lu AA21004 20 mg and 2×10 mg Tablets
- A Biomarker-Guided, Randomized, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With TRD
- A Clinical Study in Healthy Women Which Aims to Explore the Intestinal Uptake of Two Different Tablets of GRTA9906 Into the Body and the Effect of Food on it

### Drugs (68)

- Amitifadine Monoamine transporter inhibitor
- Amitriptyline Serotonin transporter inhibitor
- Amitriptyline hydrochloride Serotonin transporter inhibitor
- Amoxapine Serotonin transporter inhibitor
- Bicifadine Monoamine transporter inhibitor
- Centanafadine Monoamine transporter inhibitor
- Chlorphentermine Serotonin transporter substrate
- Chlorphentermine hydrochloride Serotonin transporter substrate
- Citalopram Serotonin transporter inhibitor
- Citalopram hydrobromide Serotonin transporter inhibitor
- Clomipramine Serotonin transporter inhibitor
- Clomipramine hydrochloride Serotonin transporter inhibitor
- Dapoxetine Serotonin transporter inhibitor
- Dasotraline Monoamine transporter inhibitor
- Desvenlafaxine Serotonin transporter inhibitor
- Desvenlafaxine fumarate Serotonin transporter inhibitor
- Desvenlafaxine succinate Serotonin transporter inhibitor
- Dothiepin Serotonin transporter inhibitor
- Duloxetine Serotonin transporter inhibitor
- Duloxetine hydrochloride Serotonin transporter inhibitor

---

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