> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/slc6a2-e24825e0-4238-596c-a718-6dd7ff85f000
> Record changed: 2026-10-13

# SLC6A2

ENSG00000103546

Target class

Transporter

Chromosome

16

Approved drugs

62

Clinical candidates (approved and in development)

77

## Clinical evidence

**Approved drugs**

62

**Clinical candidates (approved and in development)**

77

## Druggability

**Chemical probe available**

Yes

## Names

**Other names**

- NET

**Target name**

SLC6A2

**Gene name**

Solute carrier family 6 member 2

**Gene symbol**

SLC6A2

**Protein name**

Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2)

### Previous gene symbols (3)

- NET1
- NAT1
- SLC6A5

## Classification

**Gene biotype**

Protein coding

**Gene family**

Solute carrier family 6

**Target class**

Transporter

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

2

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

6.57

**Tissue specificity (Gini)**

0.815

**Tissue specificity (tau)**

0.975

## Pathways and interactions

**KEGG gene identifiers**

- hsa:6530

**Protein interaction confidence**

0.791563

**Protein interaction partners**

16

### Reactome pathways (2)

- R-HSA-442660
- R-HSA-5619109

## Genomic location

**End position**

55707645

**Start position**

55655988

**Chromosome**

16

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000103546

**HGNC ID**

HGNC:11048

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11048)

**NCBI Gene ID**

6530

**UniProt ID**

P23975

## Cellular location

- Cell membrane
- Multi-pass membrane protein . Cell projection, axon . Synapse, synaptosome .
- Cytosol
- Mitochondria

### Publication evidence

- PubMed 11343649  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11343649/)

## Tissue expression

**Tissue specificity (tau)**

0.974843

**Expression inequality (Gini)**

0.815334

### Highest expression

Expression in transcripts per million

**Testis**

6.57

**Skin - Not Sun Exposed (Suprapubic)**

1.54

**Skin - Sun Exposed (Lower leg)**

0.91

**Adipose - Subcutaneous**

0.72

**Breast - Mammary Tissue**

0.72

### All tissues (54)

Expression in transcripts per million

- Testis6.57
- Skin - Not Sun Exposed (Suprapubic)1.54
- Skin - Sun Exposed (Lower leg)0.91
- Adipose - Subcutaneous0.72
- Breast - Mammary Tissue0.72
- Esophagus - Gastroesophageal Junction0.59
- Uterus0.47
- Esophagus - Muscularis0.45
- Adipose - Visceral (Omentum)0.37
- Cervix - Endocervix0.37
- Cervix - Ectocervix0.29
- Adrenal Gland0.26
- Fallopian Tube0.23
- Vagina0.21
- Nerve - Tibial0.2
- Prostate0.16
- Minor Salivary Gland0.16
- Bladder0.16
- Small Intestine - Terminal Ileum0.1
- Kidney - Cortex0.09
- Kidney - Medulla0.09
- Ovary0.08
- Esophagus - Mucosa0.08
- Colon - Sigmoid0.08
- Artery - Coronary0.06

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (4)

- GO:0006836  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006836)
- GO:0007268  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268)
- GO:0051620  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051620)
- GO:0070050  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070050)

### Cellular components (2)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)

### Molecular functions (5)

- GO:0003779  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003779)
- GO:0005330  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005330)
- GO:0005334  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005334)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008504  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008504)

## On-target safety

- ventricular hypertrophy  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: ventricular hypertrophy  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased heart rate  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased heart rate  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- constipation  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: constipation  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased locomotor activity  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased locomotor activity  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- orthostatic hypotension  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: orthostatic hypotension  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- drug abuse/dependence  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: drug abuse/dependence  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pain  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased pain  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- tachycardia  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: tachycardia  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- increased blood pressure  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased blood pressure  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased QTc interval  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased QTc interval  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- hypertension (supine)  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: hypertension (supine)  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- decreased salivation  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased salivation  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased sleep  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased sleep  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- sweating  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: sweating  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- blurred vision  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: blurred vision  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased cardiac output  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased cardiac output  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pupillary reflex  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased pupillary reflex  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased eating  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased eating  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- congestive heart failure  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: congestive heart failure  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- urinary hesitancy  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: urinary hesitancy  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Off-target safety

- increased locomotor activity  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased locomotor activity  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- constipation  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: constipation  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- receptor binding  
### Studies

  - biochemical: NVS\_TR\_hNET, is one of one assay component(s) measured or calculated from the NVS\_TR\_hNET assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)
- increased blood pressure  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased blood pressure  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- abuse potential  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: abuse potential  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- increased heart rate  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased heart rate  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)

## Related records

### Trials (2,254)

- 'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug
- "MILNACIPRAN" in Subjects With Chronic Shoulder Pain
- \[C-11\]NPA PET-amphetamine in Cocaine Use Disorders
- 12-Week Study of Pristiq (Desvenlafaxine) Social Anxiety Disorder
- 124I-Metaiodobenzylguanidine (MIBG) PET/CT Diagnostic Imaging and Dosimetry for Patients With Neuroblastoma: A Pilot Study
- 131-I-MIBG Therapy for Refractory Neuroblastoma, Expanded Access Protocol
- 131I-Labeled MIBG for Refractory Neuroblastoma: A Compassionate Use Protocol
- 131I-Metaiodobenzylguanidine (131I-MIBG) Therapy for Relapsed/Refractory Neuroblastoma
- 131I-MIBG With Myeloablative Chemotherapy and Autologous Stem Cell Transplantation for the Treatment of High-risk Neuroblastoma
- 131MIBG to Treat Malignant Pheochromocytoma
- 48 Weeks, Study to Evaluate Overall Safety and Tolerability of Co-administration of Tesofensine and Metoprolol in Subjects With Hypothalamic Injury-induced Obesity (HIO)
- 6-week Study Treatment to Evaluate the Safety and Effectiveness of AZD2066 in Patients With Major Depressive Disorder
- 8 Week Multi-site Study of MYDAYIS® for Bipolar Depression
- A 12-Month Open Label Safety Study of Aptensio XR® in Children Ages 4-5 Years Diagnosed With ADHD
- A 52-Week Study of Bicifadine in Patients With Chronic Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
- A 6-week Study to Evaluate the Safety and Efficacy of Quillichew ERCT in 4-5 Year Old Children With ADHD.
- A Bioequivalence (BE) Study in Healthy Subjects
- A Biomarker-Guided, Randomized, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With TRD
- A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers.
- A Classroom Study to Assess the Time of Onset of Vyvanse (Lisdexamfetamine Dimesylate) in Pediatric Subjects Aged 6-12 With Attention Deficit/Hyperactivity Disorder (ADHD)

### Drugs (112)

- Amitifadine Monoamine transporter inhibitor
- Amitriptyline Norepinephrine transporter inhibitor
- Amitriptyline hydrochloride Norepinephrine transporter inhibitor
- Amoxapine Norepinephrine transporter inhibitor
- Amphetamine Norepinephrine transporter releasing agent
- Amphetamine adipate Norepinephrine transporter releasing agent
- Amphetamine aspartate Norepinephrine transporter releasing agent
- Amphetamine sulfate Norepinephrine transporter releasing agent
- Ampreloxetine Norepinephrine transporter inhibitor
- Atomoxetine Norepinephrine transporter inhibitor
- [Atomoxetine hydrochloride](https://trialight.com/data/asset/atomoxetine-hydrochloride-ec642fa5-6de5-4361-a5d5-ba620d2a4aef.md) Norepinephrine transporter inhibitor
- Benzphetamine Norepinephrine transporter releasing agent
- Benzphetamine hydrochloride Norepinephrine transporter releasing agent
- Bethanidine Norepinephrine transporter substrate
- Bethanidine sulfate Norepinephrine transporter substrate
- Bicifadine Monoamine transporter inhibitor
- Bretylium Norepinephrine transporter substrate
- Bretylium tosylate Norepinephrine transporter substrate
- Bupropion Norepinephrine transporter inhibitor
- Bupropion hydrobromide Norepinephrine transporter inhibitor

---

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