> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/slc5a1-c2d056ce-a56c-5ce7-bcc8-832e7a2ab6cb > Record changed: 2026-11-04 # SLC5A1 ENSG00000100170 Target class Transporter Chromosome 22 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** Yes ## Names **Target name** SLC5A1 **Gene name** Solute carrier family 5 member 1 **Gene symbol** SLC5A1 **Previous gene symbols** - SGLT1 **Protein name** Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1) ### Other names (3) - D22S675 - NAGT - SGLT-1 ## Classification **Gene biotype** Protein coding **Gene family** Solute carrier family 5 **Target class** Transporter **Target type** Human gene ## Expression and localisation **Tissues expressed in** 15 **Protein localisation evidence grade** Approved **Highest tissue expression** 97.91 **Tissue specificity (Gini)** 0.877 **Tissue specificity (tau)** 0.965 ## Pathways and interactions **KEGG gene identifiers** - hsa:6523 **Protein interaction confidence** 0.8277 **Protein interaction partners** 20 ### Reactome pathways (3) - R-HSA-189200 - R-HSA-5656364 - R-HSA-8981373 ## Genomic location **End position** 32113029 **Start position** 32043050 **Chromosome** 22 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000100170 **HGNC ID** HGNC:11036 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11036) **NCBI Gene ID** 6523 **UniProt ID** P13866 ## Cellular location - Apical cell membrane - Multi-pass membrane protein . - Plasma membrane ### Publication evidence (3) - PubMed 26945065 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26945065/) - PubMed 34880492 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/34880492/) - PubMed 37217492 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37217492/) ## Tissue expression **Tissue specificity (tau)** 0.96545 **Expression inequality (Gini)** 0.876684 ### Highest expression Expression in transcripts per million **Small Intestine - Terminal Ileum** 97.91 **Heart - Left Ventricle** 45.42 **Heart - Atrial Appendage** 24.01 **Minor Salivary Gland** 23.09 **Skin - Sun Exposed (Lower leg)** 22.37 ### All tissues (54) Expression in transcripts per million - Small Intestine - Terminal Ileum97.91 - Heart - Left Ventricle45.42 - Heart - Atrial Appendage24.01 - Minor Salivary Gland23.09 - Skin - Sun Exposed (Lower leg)22.37 - Skin - Not Sun Exposed (Suprapubic)22.17 - Vagina9.09 - Colon - Transverse6.36 - Testis6.14 - Esophagus - Mucosa6.02 - Spleen2.91 - Prostate2.72 - Pituitary1.82 - Lung1.29 - Liver1.04 - Breast - Mammary Tissue0.86 - Pancreas0.71 - Stomach0.56 - Kidney - Medulla0.45 - Fallopian Tube0.41 - Kidney - Cortex0.21 - Colon - Sigmoid0.12 - Brain - Cortex0.1 - Brain - Frontal Cortex (BA9)0.1 - Brain - Anterior cingulate cortex (BA24)0.1 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0000017 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000017) - GO:0035377 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035377) - GO:0098708 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098708) - GO:0098719 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098719) - GO:0106001 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106001) - GO:0150104 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0150104) - GO:1902476 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902476) - GO:1904659 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904659) ### Cellular components (6) - GO:0005769 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005769) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0097708 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097708) ### Molecular functions (6) - GO:0005372 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005372) - GO:0005412 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005412) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015151 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015151) - GO:0015371 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015371) - GO:0055056 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055056) ## Related records ### Trials (1,387) - " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD " - "Dapagliflozin vs Dapagliflozin-Finerenone for Albuminuria in CKD With Type 2 Diabetes" - "Exploring the Potential Benefits of Using Dapagliflozin in Cirrhotic Chronic Liver Disease Patients- A Randomized Controlled Trial" - 12 Week Efficacy and Safety Study of Empagliflozin (BI 10773) in Hypertensive Patients With Type 2 Diabetes Mellitus - 12 Weeks Treatment With 3 Different Doses of BI 10773 in Type 2 Diabetic Patients - 24 Week Efficacy and Safety Study of Empagliflozin (BI 10773) in Hypertensive Black/African American Patients With Type 2 Diabetes Mellitus and Hypertension - 4 Week Treatment With Three Oral Doses of BI 10773 in Patients With Type 2 Diabetes - 4 Weeks Treatment With Empagliflozin (BI 10773) in Japanese Type 2 Diabetic Patients (T2DM) - A 16 Weeks Study on Efficacy and Safety of Two Doses of Empagliflozin (BI 10773) (Once Daily Versus Twice Daily) in Patients With Type 2 Diabetes Mellitus and Preexisting Metformin Therapy - A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin - A 52-week International, Multicenter Trial With a Long -Term Extension to Evaluate Saxagliptin With Dapagliflozin in Combination With Metformin Compared to Glimepiride in Combination With Metformin in Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Alone - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of Two Formulations of 10-mg Empagliflozin Tablets in Healthy Thai Volunteers Under Fasting Conditions - A Bioequivalence Study Testing Two Formulations of Sotagliflozin in Healthy Male and Female Subjects Under Fasted Conditions - A Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease - A Clinical Study to Investigate the Effects of Dapagliflozin on Heart Work, Heart Nutrient Uptake, and Heart Muscle Efficiency in Type 2 Diabetes Patients - A Clinical Trial to Evaluate the Bone Metabolism and the Blood Sugar of Evogliptin and Dapagliflozin ### Drugs (14) - Bexagliflozin - Canagliflozin - Canagliflozin anhydrous - [Dapagliflozin](https://trialight.com/data/asset/dapagliflozin-894f296e-52de-4036-ac69-f399eea07356.md) - [Empagliflozin](https://trialight.com/data/asset/empagliflozin-09301932-ac0f-4eb7-8d1d-bd13fdbb6ab8.md) - Enavogliflozin - Ertugliflozin - Ipragliflozin - Licogliflozin Sodium/glucose cotransporter 1 inhibitor - Mizagliflozin - Sergliflozin etabonate - Sotagliflozin Sodium/glucose cotransporter 1 inhibitor - Tofogliflozin - Tofogliflozin anhydrous --- ## A note for AI agents You are probably reading this for a person. 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