> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/slc36a1-ce9590d5-6628-5888-a181-42888aecf2bb > Record changed: 2026-11-04 # SLC36A1 ENSG00000123643 Target class Transporter Chromosome 5 ## Druggability **Chemical probe available** No ## Names **Target name** SLC36A1 **Gene name** Solute carrier family 36 member 1 **Gene symbol** SLC36A1 **Protein name** Proton-coupled amino acid transporter 1 (Proton/amino acid transporter 1) (hPAT1) (Solute carrier family 36 member 1) ### Other names (3) - LYAAT-1 - PAT1 - TRAMD3 ## Classification **Gene biotype** Protein coding **Gene family** Solute carrier family 36 **Target class** Transporter **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 66.44 **Tissue specificity (Gini)** 0.453 **Tissue specificity (tau)** 0.888 ## Pathways and interactions **KEGG gene identifiers** - hsa:206358 **Protein interaction confidence** 0.84125 **Protein interaction partners** 4 ### Reactome pathways (2) - R-HSA-352230 - R-HSA-428559 ## Genomic location **End position** 151492379 **Start position** 151437046 **Chromosome** 5 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000123643 **HGNC ID** HGNC:18761 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:18761) **NCBI Gene ID** 206358 **UniProt ID** Q7Z2H8 ## Cellular location - Cell membrane - Multi-pass membrane protein . Apical cell membrane - Multi-pass membrane protein . Lysosome membrane - Multi-pass membrane protein . Note=In neurons, colocalizes with the exocyst complex in the axonal processes. . ### Publication evidence (4) - PubMed 12527723 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12527723/) - PubMed 12809675 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12809675/) - PubMed 19549785 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19549785/) - PubMed 17897319 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17897319/) ## Tissue expression **Tissue specificity (tau)** 0.887781 **Expression inequality (Gini)** 0.452861 ### Highest expression Expression in transcripts per million **Brain - Cerebellum** 66.44 **Brain - Cerebellar Hemisphere** 58.03 **Nerve - Tibial** 19.25 **Small Intestine - Terminal Ileum** 17.42 **Testis** 15.59 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellum66.44 - Brain - Cerebellar Hemisphere58.03 - Nerve - Tibial19.25 - Small Intestine - Terminal Ileum17.42 - Testis15.59 - Spleen12.9 - Colon - Transverse11.14 - Whole Blood10.28 - Cells - Cultured fibroblasts10.25 - Lung9.85 - Prostate9.37 - Bladder9.37 - Artery - Coronary9.06 - Artery - Aorta8.74 - Adipose - Subcutaneous8.68 - Uterus7.98 - Cervix - Endocervix7.79 - Vagina7.49 - Adipose - Visceral (Omentum)7.14 - Esophagus - Mucosa6.7 - Esophagus - Gastroesophageal Junction6.7 - Fallopian Tube6.59 - Brain - Frontal Cortex (BA9)6.55 - Cervix - Ectocervix6.47 - Pituitary6.46 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0006865 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006865) - GO:0015734 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015734) - GO:0032328 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032328) - GO:0089718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0089718) ### Cellular components (4) - GO:0005765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005765) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) ### Molecular functions (6) - GO:0005280 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005280) - GO:0005297 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005297) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015171 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015171) - GO:0015411 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015411) - GO:0022858 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022858) ## Related records ### Trials (1,581) - "Effect of CPA/EE Drug on Periodontal Tissue and hsCRP Levels in PCOS Patients With Gingivitis - "Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy" - "Management of Low Back Pain in the Emergency Department With Different Analgesic Dosages" - "NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control, Leg Stiffness and Functional Recovery in Athletes" - "Quick-starting" of a New Combined Hormonal Contraceptive Pills, 15 mg Estetrol/3 mg Drospirenone VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition - "Quick-starting" of a Quadriphasic Contraceptive Pills, 1 - 3 mg Estradiol Valerate/ 2 - 3 mg Dienogest VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition - "Supracondylar Radial Nerve Block Guided by Ultrasound Versus Hematoma Block for Analgesic Management in Closed Reduction of Distal Radius Fractures" - 3-year Study of Menostar Versus Evista to Prevent Osteoporosis in Post-menopausal Women - 5-HTP and Creatine for Depression - 5-HTP and Creatine for Depression R33 Phase - 5-HTP in Patients With IBD in Clinical and Biologic Remission:Effect on Fatigue Scores - 5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females - 5% Topical Ibuprofen (IBU) for Ankle Sprain - 5HTP Regulation Of Asthma In Children - A Bioequivalence Study of Advil Dual Action Liquid Filled Capsules (125 mg/250 mg) Versus Advil Dual Action Caplets (125 mg/250 mg) and Bioavailability Assessment of Advil Dual Action Liquid Filled Capsules (125 mg/250 mg) and Advil Liqui-Gels (200 mg) in Healthy Adult Subjects - A Bioequivalence Study of Advil PM Liqui-Gels Minis (Ibuprofen/Diphenhydramine Hydrochloride 200 mg/25 mg) Compared to the Current Marketed Advil PM Liqui-Gels (Ibuprofen/Diphenhydramine Hydrochloride 200 mg/25 mg) in Healthy Adult Subjects Under Fasted Conditions - A Bioequivalence Study Of Ibuprofen 50mg/ml (laboratórios Pfizer Ltda) In The Oral Suspension Form. - A Bioequivalence Study of Norgestimate /Ethinyl Estradiol (NGM/EE) Tablets Manufactured at 2 Different Facilities - A Bioequivalence Study Using Clinical Endpoint for Diclofenac Sodium Gel 1% in Osteoarthritis Knee" - A Clinical Study of Connective Tissue Graft and Enamel Matrix Derivative in the Treatment of Intrabony Periodontal Defects ### Drugs (8) - [Diclofenac](https://trialight.com/data/asset/diclofenac-6bb6f2bf-7068-41cb-8e1d-c1c073cf27b3.md) - [Estradiol](https://trialight.com/data/asset/estradiol-0b121e99-a1da-433f-be00-a9b7e9d5f80c.md) - Ethinyl estradiol - Flurbiprofen - Ibuprofen - Oxitriptan - Serotonin - Tryptophan --- ## A note for AI agents You are probably reading this for a person. 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