> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/slc29a4-837ae7a3-e854-5a3f-a261-46e2d3aabfcc > Record changed: 2026-11-04 # SLC29A4 ENSG00000164638 Target class Transporter Chromosome 7 ## Druggability **Chemical probe available** No ## Names **Target name** SLC29A4 **Gene name** Solute carrier family 29 member 4 **Gene symbol** SLC29A4 **Protein name** Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (PMAT) (Solute carrier family 29 member 4) ### Other names (2) - FLJ34923 - ENT4 ## Classification **Gene biotype** Protein coding **Gene family** Solute carrier family 29 **Target class** Transporter **Target type** Human gene ## Expression and localisation **Tissues expressed in** 44 **Protein localisation evidence grade** Approved **Highest tissue expression** 20.11 **Tissue specificity (Gini)** 0.501 **Tissue specificity (tau)** 0.779 ## Pathways and interactions **KEGG gene identifiers** - hsa:222962 **Reactome pathways** - R-HSA-83936 **Protein interaction confidence** 0.743 **Protein interaction partners** 8 ## Genomic location **End position** 5307194 **Start position** 5274369 **Chromosome** 7 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000164638 **HGNC ID** HGNC:23097 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:23097) **NCBI Gene ID** 222962 **UniProt ID** Q7RTT9 ## Cellular location - Cell membrane - Multi-pass membrane protein . Apical cell membrane - Multi-pass membrane protein . Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells (PubMed:16873718). Targeted to the apical membranes of differentiated kidney epithelial cells (PubMed:17018840). Localized to the apical blood-cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelium (PubMed:23255610). . - Cytokinetic bridge - Microtubules ### Publication evidence (6) - PubMed 15448143 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15448143/) - PubMed 16873718 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16873718/) - PubMed 17121826 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17121826/) - PubMed 20858707 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20858707/) - PubMed 17018840 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17018840/) - PubMed 23255610 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23255610/) ## Tissue expression **Tissue specificity (tau)** 0.778764 **Expression inequality (Gini)** 0.50065 ### Highest expression Expression in transcripts per million **Brain - Hypothalamus** 20.11 **Brain - Cortex** 15.75 **Adipose - Subcutaneous** 14.86 **Brain - Substantia nigra** 13.84 **Brain - Anterior cingulate cortex (BA24)** 13.54 ### All tissues (54) Expression in transcripts per million - Brain - Hypothalamus20.11 - Brain - Cortex15.75 - Adipose - Subcutaneous14.86 - Brain - Substantia nigra13.84 - Brain - Anterior cingulate cortex (BA24)13.54 - Adipose - Visceral (Omentum)12.39 - Brain - Frontal Cortex (BA9)12.25 - Thyroid10.78 - Brain - Cerebellum9.32 - Brain - Amygdala7.73 - Brain - Hippocampus7.69 - Brain - Nucleus accumbens (basal ganglia)7.07 - Breast - Mammary Tissue6.74 - Cervix - Ectocervix6.49 - Cervix - Endocervix6.19 - Kidney - Medulla6.17 - Brain - Cerebellar Hemisphere6.14 - Pancreas5.6 - Brain - Caudate (basal ganglia)5.24 - Stomach4.13 - Testis4 - Brain - Putamen (basal ganglia)3.89 - Prostate3.7 - Pituitary3.55 - Uterus3.55 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (16) - GO:0001692 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001692) - GO:0006836 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006836) - GO:0006837 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006837) - GO:0015844 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015844) - GO:0015872 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015872) - GO:0015874 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015874) - GO:0032238 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032238) - GO:0048241 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048241) - GO:0051608 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051608) - GO:0051610 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051610) - GO:0051615 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051615) - GO:0051620 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051620) - GO:0051625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051625) - GO:0055085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055085) - GO:0090494 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090494) - GO:0140115 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140115) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016323 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) ### Molecular functions (5) - GO:0005326 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005326) - GO:0005337 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005337) - GO:0008504 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008504) - GO:0015562 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015562) - GO:0022857 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022857) ## Related records ### Trials (471) - "Evaluation by Transcranial Magnetic Stimulation of the Benefit of Fluoxetine on Motor Recovery After Stroke" - "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up - 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression - A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone - [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md) - A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation - A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder - A Drug Interaction Study to Assess the Effect of LY2603618 on the Metabolic Pathway of Desipramine - A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants - A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323. - A Multicenter Clinical Study on Shuganjieyu Capsule Combined With Fluoxetine in the Treatment of Depression - A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder - A Phase 1 Study Comparing AVP-786 With AVP-923 - A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects - A Phase I Study to Assess PK of AZD7986 Alone & With Verapamil, Itraconazole or Diltiazem in Healthy Subjects - A Phase I/II Trial to Preserve Residual Insulin Secretion in Children With Recent Onset Type 1 Diabetes by Giving Verapamil - A Phase II Trial Comparing Z-102 With Placebo In Patients With Moderate To Severe Rheumatoid Arthritis - A Phase-1 Study to Assess the Pharmacokinetics, Safety and Tolerability of AVP-786 in Healthy Volunteers - A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity - A Positron Emission Topographic (PET) Study on Depression Patient With Electroacupuncture ### Drugs (7) - Cimetidine - Desipramine - Dipyridamole - Fluoxetine - [Quinidine](https://trialight.com/data/asset/quinidine-87aba552-7096-4212-a930-5c3f4b7ce394.md) - Quinine - Verapamil --- ## A note for AI agents You are probably reading this for a person. 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