SLC29A4
ENSG00000164638
Target class
Transporter
Chromosome
7
- Chemical probe available
- No
- Target name
- SLC29A4
- Gene name
- Solute carrier family 29 member 4
- Gene symbol
- SLC29A4
- Protein name
- Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (PMAT) (Solute carrier family 29 member 4)
- FLJ34923
- ENT4
- Gene biotype
- Protein coding
- Gene family
- Solute carrier family 29
- Target class
- Transporter
- Target type
- Human gene
- Tissues expressed in
- 44
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 20.11
- Tissue specificity (Gini)
- 0.501
- Tissue specificity (tau)
- 0.779
- KEGG gene identifiers
- hsa:222962
- Reactome pathways
- R-HSA-83936
- Protein interaction confidence
- 0.743
- Protein interaction partners
- 8
- End position
- 5307194
- Start position
- 5274369
- Chromosome
- 7
- Strand
- Forward
- Cell membrane
- Multi-pass membrane protein . Apical cell membrane
- Multi-pass membrane protein . Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells (PubMed:16873718). Targeted to the apical membranes of differentiated kidney epithelial cells (PubMed:17018840). Localized to the apical blood-cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelium (PubMed:23255610). .
- Cytokinetic bridge
- Microtubules
- PubMed 15448143
- PubMed 16873718
- PubMed 17121826
- PubMed 20858707
- PubMed 17018840
- PubMed 23255610
- Tissue specificity (tau)
- 0.778764
- Expression inequality (Gini)
- 0.50065
Expression in transcripts per million
- Brain - Hypothalamus
- 20.11
- Brain - Cortex
- 15.75
- Adipose - Subcutaneous
- 14.86
- Brain - Substantia nigra
- 13.84
- Brain - Anterior cingulate cortex (BA24)
- 13.54
Expression in transcripts per million
- Brain - Hypothalamus20.11
- Brain - Cortex15.75
- Adipose - Subcutaneous14.86
- Brain - Substantia nigra13.84
- Brain - Anterior cingulate cortex (BA24)13.54
- Adipose - Visceral (Omentum)12.39
- Brain - Frontal Cortex (BA9)12.25
- Thyroid10.78
- Brain - Cerebellum9.32
- Brain - Amygdala7.73
- Brain - Hippocampus7.69
- Brain - Nucleus accumbens (basal ganglia)7.07
- Breast - Mammary Tissue6.74
- Cervix - Ectocervix6.49
- Cervix - Endocervix6.19
- Kidney - Medulla6.17
- Brain - Cerebellar Hemisphere6.14
- Pancreas5.6
- Brain - Caudate (basal ganglia)5.24
- Stomach4.13
- Testis4
- Brain - Putamen (basal ganglia)3.89
- Prostate3.7
- Pituitary3.55
- Uterus3.55
And 29 more, listed on the interactive page.
- GO:0001692
- GO:0006836
- GO:0006837
- GO:0015844
- GO:0015872
- GO:0015874
- GO:0032238
- GO:0048241
- GO:0051608
- GO:0051610
- GO:0051615
- GO:0051620
- GO:0051625
- GO:0055085
- GO:0090494
- GO:0140115
- GO:0005886
- GO:0016323
- GO:0016324
- GO:0005326
- GO:0005337
- GO:0008504
- GO:0015562
- GO:0022857
Related records
Trials (471)
- "Evaluation by Transcranial Magnetic Stimulation of the Benefit of Fluoxetine on Motor Recovery After Stroke"
- "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up
- 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
- A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone
- A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)
- A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation
- A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder
- A Drug Interaction Study to Assess the Effect of LY2603618 on the Metabolic Pathway of Desipramine
- A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants
- A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323.
- A Multicenter Clinical Study on Shuganjieyu Capsule Combined With Fluoxetine in the Treatment of Depression
- A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder
- A Phase 1 Study Comparing AVP-786 With AVP-923
- A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects
- A Phase I Study to Assess PK of AZD7986 Alone & With Verapamil, Itraconazole or Diltiazem in Healthy Subjects
- A Phase I/II Trial to Preserve Residual Insulin Secretion in Children With Recent Onset Type 1 Diabetes by Giving Verapamil
- A Phase II Trial Comparing Z-102 With Placebo In Patients With Moderate To Severe Rheumatoid Arthritis
- A Phase-1 Study to Assess the Pharmacokinetics, Safety and Tolerability of AVP-786 in Healthy Volunteers
- A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
- A Positron Emission Topographic (PET) Study on Depression Patient With Electroacupuncture
Drugs (7)
- Cimetidine
- Desipramine
- Dipyridamole
- Fluoxetine
- Quinidine
- Quinine
- Verapamil