> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/slc22a6-f0060e0c-1f01-505b-86bb-0e7f00115759
> Record changed: 2026-10-13

# SLC22A6

ENSG00000197901

Target class

Transporter

Chromosome

11

Approved drugs

1

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

No

## Names

**Target name**

SLC22A6

**Gene name**

Solute carrier family 22 member 6

**Gene symbol**

SLC22A6

**Protein name**

Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1)

### Other names (3)

- ROAT1
- PAHT
- OAT1

## Classification

**Gene biotype**

Protein coding

**Gene family**

Solute carrier family 22

**Target class**

Transporter

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

11

**Highest tissue expression**

103.03

**Tissue specificity (Gini)**

0.941

**Tissue specificity (tau)**

0.992

## Pathways and interactions

**KEGG gene identifiers**

- hsa:9356

**Reactome pathways**

- R-HSA-561048

**Protein interaction confidence**

0.747308

**Protein interaction partners**

13

## Genomic location

**End position**

62984967

**Start position**

62936385

**Chromosome**

11

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000197901

**HGNC ID**

HGNC:10970

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10970)

**NCBI Gene ID**

9356

**UniProt ID**

Q4U2R8

## Cellular location

- Basolateral cell membrane
- Multi-pass membrane protein . Basal cell membrane
- Multi-pass membrane protein . Note=Localized to the basolateral membrane of renal proximal tubular cells (PubMed:9887087). Localized to the basal membrane of Sertoli cells (PubMed:35307651). .

### Publication evidence (2)

- PubMed 9887087  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9887087/)
- PubMed 35307651  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35307651/)

## Tissue expression

**Tissue specificity (tau)**

0.99177

**Expression inequality (Gini)**

0.941493

### Highest expression

Expression in transcripts per million

**Kidney - Cortex**

103.03

**Kidney - Medulla**

21.43

**Brain - Substantia nigra**

4.48

**Brain - Hypothalamus**

3.43

**Brain - Nucleus accumbens (basal ganglia)**

2.73

### All tissues (54)

Expression in transcripts per million

- Kidney - Cortex103.03
- Kidney - Medulla21.43
- Brain - Substantia nigra4.48
- Brain - Hypothalamus3.43
- Brain - Nucleus accumbens (basal ganglia)2.73
- Brain - Caudate (basal ganglia)2.59
- Brain - Putamen (basal ganglia)1.72
- Brain - Spinal cord (cervical c-1)1.57
- Brain - Amygdala1.39
- Brain - Cortex1.24
- Brain - Anterior cingulate cortex (BA24)1.17
- Brain - Frontal Cortex (BA9)0.88
- Brain - Cerebellum0.86
- Brain - Hippocampus0.75
- Brain - Cerebellar Hemisphere0.55
- Pituitary0.05
- Nerve - Tibial0.04
- Testis0.03
- Fallopian Tube0.01
- Skin - Sun Exposed (Lower leg)0.01
- Cervix - Endocervix0.01
- Small Intestine - Terminal Ileum0
- Heart - Atrial Appendage0
- Adrenal Gland0
- Minor Salivary Gland0

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (4)

- GO:0015732  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015732)
- GO:0015742  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015742)
- GO:0055085  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055085)
- GO:0097254  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097254)

### Cellular components (4)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0009925  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009925)
- GO:0016323  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)

### Molecular functions (7)

- GO:0005452  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005452)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0015132  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015132)
- GO:0015139  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015139)
- GO:0015297  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015297)
- GO:0022857  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022857)
- GO:0042910  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042910)

## On-target safety

- Decrease, Population growth rate  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
### Biological samples

  - proximal tubule  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/138)
- Increased Mortality  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
### Biological samples

  - proximal tubule  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/138)

## Related records

### Trials (61)

- 10-Propargyl-10-Deazaaminopterin Plus Probenecid in Treating Patients With Advanced Solid Tumors
- A Clinical Study of MK-8527 in Healthy Participants (MK-8527-021)
- A Drug Interaction Study of VI-0521 With Metformin, Sitagliptan and Probenecid in Healthy Subjects.
- A Phase 1 Study to Evaluate the Effect of the Organic Anion Transporter Inhibitor Probenecid on the Pharmacokinetics of JNJ-64041575 in Healthy Adults
- A Relative Bioavailability Study With a Novel PanCytoVir™ Oral Suspension (100 mg/ml)
- A Study in Healthy People to Test How 2 Different Formulations of BI 690517 Are Taken up in the Body and How Probenecid Influences the Amount of BI 690517 in the Blood
- A Study of Baricitinib and Probenecid in Healthy Participants
- A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease
- A Study to Assess Pharmacokinetics of PF-04965842 and Its Metabolites and Effect of Probenecid in Healthy Participants
- A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics and the Effect of Probenecid on Povorcitinib Pharmacokinetics When Administered Orally to Healthy Adult Participants
- A Study to Assess the Effects of Multiple-Dose Probenecid on the Multiple-Dose Pharmacokinetics of Canagliflozin in Healthy Volunteers
- A Study to Evaluate the Drug-drug Interactions (DDIs) of DBPR108 With Warfarin Sodium, Digoxin, Probenecid in Healthy Subjects
- A Study to Evaluate the Efficacy of PanCytoVir™ for the Treatment of Non-Hospitalized Patients With COVID-19 Infection
- A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients
- A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060
- A Trial Investigating the Effect of Probenecid and Ciclosporin on the Concentrations of SNAC in Healthy Subjects
- Addition of Probenecid to Penicillin-V Therapy
- An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS
- Assessment of a New "Boosting" Strategy for HIV Pre-exposure Prophylaxis in Healthy Volunteers
- AV-101 Alone and in Combination With Probenecid in Healthy Subjects

### Drugs (2)

- Pratosartan Solute carrier family 22 member 6 inhibitor
- [Probenecid](https://trialight.com/data/asset/probenecid-0864a3cb-3764-4994-8995-3400af689d1e.md) Solute carrier family 22 member 6 inhibitor

---

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