> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/slc22a12-6d9b9159-a283-5eb9-8699-67b6a8275d07 > Record changed: 2026-10-13 # SLC22A12 ENSG00000197891 Target class Transporter Chromosome 11 Approved drugs 3 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** No ## Names **Target name** SLC22A12 **Gene name** Solute carrier family 22 member 12 **Gene symbol** SLC22A12 **Protein name** Solute carrier family 22 member 12 (Organic anion transporter 4-like protein) (Renal-specific transporter) (RST) (Urate anion exchanger 1) (URAT1) (Urate:anion antiporter SLC22A12) ### Other names (5) - OAT4L - RST - URAT1 - hURAT1 - UAT ## Classification **Gene biotype** Protein coding **Gene family** Solute carrier family 22 **Target class** Transporter **Target type** Human gene ## Expression and localisation **Tissues expressed in** 2 **Highest tissue expression** 53.35 **Tissue specificity (Gini)** 0.969 **Tissue specificity (tau)** 0.995 ## Pathways and interactions **KEGG gene identifiers** - hsa:116085 **Protein interaction confidence** 0.85125 **Protein interaction partners** 12 ### Reactome pathways (2) - R-HSA-561048 - R-HSA-5619071 ## Genomic location **End position** 64602353 **Start position** 64590641 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000197891 **HGNC ID** HGNC:17989 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:17989) **NCBI Gene ID** 116085 **UniProt ID** Q96S37 ## Cellular location - Apical cell membrane - Multi-pass membrane protein . ### Publication evidence (4) - PubMed 12024214 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12024214/) - PubMed 22194875 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22194875/) - PubMed 35144162 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35144162/) - PubMed 35462902 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35462902/) ## Tissue expression **Tissue specificity (tau)** 0.995247 **Expression inequality (Gini)** 0.9686 ### Highest expression Expression in transcripts per million **Kidney - Cortex** 53.35 **Kidney - Medulla** 12.43 **Testis** 0.13 **Brain - Cerebellum** 0.12 **Adipose - Subcutaneous** 0.11 ### All tissues (54) Expression in transcripts per million - Kidney - Cortex53.35 - Kidney - Medulla12.43 - Testis0.13 - Brain - Cerebellum0.12 - Adipose - Subcutaneous0.11 - Adipose - Visceral (Omentum)0.11 - Brain - Cerebellar Hemisphere0.09 - Breast - Mammary Tissue0.06 - Liver0.03 - Ovary0.02 - Minor Salivary Gland0.02 - Fallopian Tube0.02 - Artery - Coronary0.02 - Artery - Aorta0.02 - Cervix - Endocervix0.01 - Cervix - Ectocervix0.01 - Thyroid0.01 - Vagina0.01 - Uterus0.01 - Nerve - Tibial0.01 - Artery - Tibial0.01 - Lung0.01 - Pituitary0.01 - Colon - Sigmoid0.01 - Skin - Sun Exposed (Lower leg)0.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0009410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009410) - GO:0015747 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015747) - GO:0046415 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046415) ### Cellular components (4) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015143 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015143) - GO:0030165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030165) ## Related records ### Trials (82) - A Multicentre, Randomized, Double-blind, Allopurinol Controlled Study to Evaluate the Efficacy and Safety of SHR4640 in Subjects With Gout - A PD/Safety Study of RDEA3170 in Combination With Febuxostat for Treating Gout or Asymptomatic Hyperuricemia Patients - A Phase 2 Trial of Dotinurad in Xanthine Oxidase Inhibitor (XOI) Intolerant/Uricase Failure Gout Participants - A Safety and Efficacy Study of SHR4640 and Febuxostat in Subjects With Hyperuricemia - A Single and Multiple Dose Study of Dotinurad in Chinese Healthy Participants - A Single Dose Study of SHR4640 in Healthy Male Volunteers - A Study in Healthy Subjects to Assess Drug Availability of 4 Different Formulations of Verinurad and Allopurinol - A Study of Dotinurad Versus Allopurinol in Participants With Gout - A Study of Dotinurad Versus Allopurinol in Tophaceous Gout - A Study of Evaluating the Efficacy and Safety of SHR4640 in Subjects With Gout - A Study of Verinurad and Allopurinol in Patients With Chronic Kidney Disease and Hyperuricaemia - A Study to Assess the Effect of Intensive Uric Acid (UA) Lowering Therapy With RDEA3170, Febuxostat, Dapagliflozin on Urinary Excretion of UA - A Study to Assess the Effect of Verinurad on the Electric Activity of the Heart - A Study to Assess the Safety and Pharmacokinetics of Verinurad and Allopurinol in Asian and Chinese Subjects - A Study to Evaluate Efficacy of Dotinurad and Febuxostat for the Treatment of Participants With Gout - Acute Effects of Benzbromaron on the Pulmonary Circulation - Benzbromarone-Controlled, Double-Blind, Comparative Study of FYU-981 in Hyperuricemia With or Without Gout - Bioavailability of Lesinurad and Intravenous \[14C\]Lesinurad - Bioequivalence Study of 2 Sizes of SHR4640 Tablets Orally in Healthy Subjects - Clinical Pharmacology of FYU-981 (Effect on QT/QTc Interval) ### Drugs (8) - Arhalofenate Solute carrier family 22 member 12 inhibitor - Benzbromarone Solute carrier family 22 member 12 inhibitor - Dotinurad Solute carrier family 22 member 12 inhibitor - Lesinurad Solute carrier family 22 member 12 inhibitor - Pratosartan Solute carrier family 22 member 12 inhibitor - [SHR-4640](https://trialight.com/data/asset/shr-4640-284efbb4-c1fa-416d-b7f3-b7d0df31f0aa.md) Solute carrier family 22 member 12 inhibitor - Sulfinpyrazone Solute carrier family 22 member 12 inhibitor - Verinurad Solute carrier family 22 member 12 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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