> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/slc22a11-1555ecf8-5d9e-5c53-958d-c3302f3c3bf3 > Record changed: 2026-10-13 # SLC22A11 ENSG00000168065 Target class Transporter Chromosome 11 Approved drugs 1 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** No ## Names **Other names** - OAT4 **Target name** SLC22A11 **Gene name** Solute carrier family 22 member 11 **Gene symbol** SLC22A11 **Protein name** Solute carrier family 22 member 11 (Organic anion transporter 4) (OAT4) (Organic anion:dicarboxylate exchanger OAT4) ## Classification **Gene biotype** Protein coding **Gene family** Solute carrier family 22 **Target class** Transporter **Target type** Human gene ## Expression and localisation **Tissues expressed in** 2 **Highest tissue expression** 28.42 **Tissue specificity (Gini)** 0.942 **Tissue specificity (tau)** 0.992 ## Pathways and interactions **KEGG gene identifiers** - hsa:55867 **Reactome pathways** - R-HSA-561048 **Protein interaction confidence** 0.806636 **Protein interaction partners** 11 ## Genomic location **End position** 64572875 **Start position** 64555690 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000168065 **HGNC ID** HGNC:18120 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:18120) **NCBI Gene ID** 55867 **UniProt ID** Q9NSA0 ## Cellular location - Cell membrane - Multi-pass membrane protein . Apical cell membrane - Multi-pass membrane protein . Basal cell membrane - Multi-pass membrane protein . Note=Expressed at the apical membrane of the proximal tubule epithelial cells (PubMed:15037815). Expressed at the basal membrane of the syncytiotrophoblast (PubMed:12409283). . ### Publication evidence (4) - PubMed 15291761 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15291761/) - PubMed 15576633 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15576633/) - PubMed 15037815 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15037815/) - PubMed 12409283 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12409283/) ## Tissue expression **Tissue specificity (tau)** 0.992246 **Expression inequality (Gini)** 0.941646 ### Highest expression Expression in transcripts per million **Kidney - Cortex** 28.42 **Kidney - Medulla** 9.37 **Testis** 0.28 **Spleen** 0.15 **Cervix - Endocervix** 0.14 ### All tissues (54) Expression in transcripts per million - Kidney - Cortex28.42 - Kidney - Medulla9.37 - Testis0.28 - Spleen0.15 - Cervix - Endocervix0.14 - Adrenal Gland0.13 - Liver0.12 - Ovary0.09 - Brain - Cerebellum0.09 - Uterus0.09 - Brain - Cerebellar Hemisphere0.09 - Thyroid0.07 - Pituitary0.06 - Cervix - Ectocervix0.06 - Prostate0.06 - Fallopian Tube0.05 - Pancreas0.05 - Brain - Substantia nigra0.04 - Breast - Mammary Tissue0.04 - Artery - Aorta0.04 - Nerve - Tibial0.04 - Brain - Spinal cord (cervical c-1)0.04 - Colon - Transverse0.03 - Small Intestine - Terminal Ileum0.03 - Minor Salivary Gland0.03 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0015732 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015732) - GO:0046415 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046415) - GO:0055085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055085) ### Cellular components (5) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009897) - GO:0009925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009925) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (5) - GO:0005452 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005452) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015132 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015132) - GO:0015291 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015291) - GO:0022857 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022857) ## Related records ### Trials (61) - 10-Propargyl-10-Deazaaminopterin Plus Probenecid in Treating Patients With Advanced Solid Tumors - A Clinical Study of MK-8527 in Healthy Participants (MK-8527-021) - A Drug Interaction Study of VI-0521 With Metformin, Sitagliptan and Probenecid in Healthy Subjects. - A Phase 1 Study to Evaluate the Effect of the Organic Anion Transporter Inhibitor Probenecid on the Pharmacokinetics of JNJ-64041575 in Healthy Adults - A Relative Bioavailability Study With a Novel PanCytoVir™ Oral Suspension (100 mg/ml) - A Study in Healthy People to Test How 2 Different Formulations of BI 690517 Are Taken up in the Body and How Probenecid Influences the Amount of BI 690517 in the Blood - A Study of Baricitinib and Probenecid in Healthy Participants - A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease - A Study to Assess Pharmacokinetics of PF-04965842 and Its Metabolites and Effect of Probenecid in Healthy Participants - A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics and the Effect of Probenecid on Povorcitinib Pharmacokinetics When Administered Orally to Healthy Adult Participants - A Study to Assess the Effects of Multiple-Dose Probenecid on the Multiple-Dose Pharmacokinetics of Canagliflozin in Healthy Volunteers - A Study to Evaluate the Drug-drug Interactions (DDIs) of DBPR108 With Warfarin Sodium, Digoxin, Probenecid in Healthy Subjects - A Study to Evaluate the Efficacy of PanCytoVir™ for the Treatment of Non-Hospitalized Patients With COVID-19 Infection - A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients - A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060 - A Trial Investigating the Effect of Probenecid and Ciclosporin on the Concentrations of SNAC in Healthy Subjects - Addition of Probenecid to Penicillin-V Therapy - An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS - Assessment of a New "Boosting" Strategy for HIV Pre-exposure Prophylaxis in Healthy Volunteers - AV-101 Alone and in Combination With Probenecid in Healthy Subjects ### Drugs (1) - [Probenecid](https://trialight.com/data/asset/probenecid-0864a3cb-3764-4994-8995-3400af689d1e.md) Solute carrier family 22 member 11 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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