> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/slc19a1-3770d351-aa32-5e1c-a2f9-4e0b3860e579
> Record changed: 2026-11-04

# SLC19A1

ENSG00000173638

Target class

Transporter

Chromosome

21

## Clinical evidence

**ClinGen gene-disease validity**

Limited

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

SLC19A1

**Gene name**

Solute carrier family 19 member 1

**Gene symbol**

SLC19A1

**Protein name**

Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)

### Other names (6)

- FOLT
- RFC1
- IFC-1
- RFC
- hRFC
- RFT-1

## Classification

**Gene biotype**

Protein coding

**Gene family**

Minor histocompatibility antigens|Solute carrier family 19

**Target class**

Transporter

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

53

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

19.56

**Tissue specificity (Gini)**

0.302

**Tissue specificity (tau)**

0.702

## Pathways and interactions

**KEGG gene identifiers**

- hsa:6573

**Reactome pathways**

- R-HSA-196757

**Protein interaction confidence**

0.7856

**Protein interaction partners**

10

## Genomic location

**End position**

45573564

**Start position**

45493572

**Chromosome**

21

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000173638

**HGNC ID**

HGNC:10937

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10937)

**NCBI Gene ID**

6573

**UniProt ID**

P41440

## Cellular location

- Cell membrane
- Multi-pass membrane protein . Apical cell membrane
- Multi-pass membrane protein . Basolateral cell membrane
- Multi-pass membrane protein .
- Plasma membrane

### Publication evidence (9)

- PubMed 10347183  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10347183/)
- PubMed 10787414  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10787414/)
- PubMed 15337749  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15337749/)
- PubMed 16115875  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16115875/)
- PubMed 36071163  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36071163/)
- PubMed 36265513  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36265513/)
- PubMed 36575193  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36575193/)
- PubMed 36745868  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36745868/)
- PubMed 9767079  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9767079/)

## Tissue expression

**Tissue specificity (tau)**

0.702107

**Expression inequality (Gini)**

0.302256

### Highest expression

Expression in transcripts per million

**Whole Blood**

19.56

**Lung**

13.11

**Cervix - Ectocervix**

12.7

**Ovary**

12.29

**Spleen**

11.96

### All tissues (54)

Expression in transcripts per million

- Whole Blood19.56
- Lung13.11
- Cervix - Ectocervix12.7
- Ovary12.29
- Spleen11.96
- Nerve - Tibial11.68
- Cervix - Endocervix11.11
- Thyroid11.03
- Brain - Cerebellum9.29
- Cells - EBV-transformed lymphocytes8.93
- Brain - Cerebellar Hemisphere8.16
- Cells - Cultured fibroblasts7.34
- Artery - Tibial7.33
- Artery - Coronary7.32
- Fallopian Tube7.14
- Artery - Aorta7.07
- Brain - Cortex6.98
- Uterus6.42
- Liver6.34
- Brain - Caudate (basal ganglia)6.03
- Adrenal Gland6
- Prostate5.84
- Brain - Putamen (basal ganglia)5.83
- Brain - Frontal Cortex (BA9)5.67
- Small Intestine - Terminal Ileum5.39

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (8)

- GO:0015884  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015884)
- GO:0046655  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046655)
- GO:0051958  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051958)
- GO:0098838  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098838)
- GO:0140361  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140361)
- GO:0141111  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0141111)
- GO:0150104  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0150104)
- GO:1904447  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904447)

### Cellular components (3)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0016323  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323)
- GO:0016324  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324)

### Molecular functions (6)

- GO:0008517  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008517)
- GO:0008518  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008518)
- GO:0015297  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015297)
- GO:0015350  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015350)
- GO:0061507  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061507)
- GO:0140360  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140360)

## Related records

### Trials (1,401)

- "Comparing Methotrexate Usage Techniques to Prevent Proliferative Vitreoretinopaty After Retinal Detachment Vitrectomy"
- \[CREMA\]Combination of R-M Followed by R-A in Elderly Patients With Primary CNS Lymphoma
- 05-001: Treatment of Acute Lymphoblastic Leukemia in Children
- 2-week dc of MTX and Influenza Vaccination in RA
- 4 x Epirubicin, Cyclophosphamide, Followed by 4 x Docetaxel Versus 6 x CMF / 6 x CEF
- 4B951, Combination Chemotherapy in Treating Patients With Bladder Cancer
- 506U78 in Treating Patients With Refractory Hematologic Cancer
- A 30-month Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate in Erosive Hand OA.
- A Bioavailability Study of Methotrexate 25 mg Administered by Needle Injection and a Pre Filled Needle-free Device in Healthy Volunteers.
- A Canadian Study to Evaluate Early Use of Adalimumab After Methotrexate Failure in Early Rheumatoid Arthritis
- A Clinical Research on the Relation of Blood Drug Concentration and Calcium Folinate Rescued in High-dose MTX Therapy
- A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014)
- A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA）
- A Clinical Trial Evaluating Patients With Primary Vitreoretinal Lymphoma
- A Clinical Trial in Patients With Breast Cancer Susceptibility Gene (BRCA) Defective Tumours
- A Clinical Trial of Decitabine in Relapsed or Refractory T-lymphoblastic Lymphoma
- A Clinical Trial of MK-8690 in Participants With Rheumatoid Arthritis (MK-8690-004)
- A Clinical Trial of Safety and Tolerance of TQH3821 Tablets in Adult Healthy Subjects
- A Clinical Trial to Evaluate Effect of IAE0972 Combined with Chemotherapy for R/M HNSCC or NPC(Note: It is Currently Phase II.).
- A Clinical Trial Using Metronomic Oral Low-dose Cyclophosphamide Alternating With Low-dose Oral Methotrexate With Continuous Celecoxib and Weekly Vinblastine in Children and Adolescents With Relapsed or Progressing soliD Tumours.

### Drugs (1)

- [Methotrexate](https://trialight.com/data/asset/methotrexate-aa7ef9da-5b6e-44a1-942c-610e3de14a1d.md)

---

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