SLC19A1
ENSG00000173638
Target class
Transporter
Chromosome
21
- ClinGen gene-disease validity
- Limited
- Chemical probe available
- Yes
- Target name
- SLC19A1
- Gene name
- Solute carrier family 19 member 1
- Gene symbol
- SLC19A1
- Protein name
- Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)
- FOLT
- RFC1
- IFC-1
- RFC
- hRFC
- RFT-1
- Gene biotype
- Protein coding
- Gene family
- Minor histocompatibility antigens|Solute carrier family 19
- Target class
- Transporter
- Target type
- Human gene
- Tissues expressed in
- 53
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 19.56
- Tissue specificity (Gini)
- 0.302
- Tissue specificity (tau)
- 0.702
- KEGG gene identifiers
- hsa:6573
- Reactome pathways
- R-HSA-196757
- Protein interaction confidence
- 0.7856
- Protein interaction partners
- 10
- End position
- 45573564
- Start position
- 45493572
- Chromosome
- 21
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein . Apical cell membrane
- Multi-pass membrane protein . Basolateral cell membrane
- Multi-pass membrane protein .
- Plasma membrane
- PubMed 10347183
- PubMed 10787414
- PubMed 15337749
- PubMed 16115875
- PubMed 36071163
- PubMed 36265513
- PubMed 36575193
- PubMed 36745868
- PubMed 9767079
- Tissue specificity (tau)
- 0.702107
- Expression inequality (Gini)
- 0.302256
Expression in transcripts per million
- Whole Blood
- 19.56
- Lung
- 13.11
- Cervix - Ectocervix
- 12.7
- Ovary
- 12.29
- Spleen
- 11.96
Expression in transcripts per million
- Whole Blood19.56
- Lung13.11
- Cervix - Ectocervix12.7
- Ovary12.29
- Spleen11.96
- Nerve - Tibial11.68
- Cervix - Endocervix11.11
- Thyroid11.03
- Brain - Cerebellum9.29
- Cells - EBV-transformed lymphocytes8.93
- Brain - Cerebellar Hemisphere8.16
- Cells - Cultured fibroblasts7.34
- Artery - Tibial7.33
- Artery - Coronary7.32
- Fallopian Tube7.14
- Artery - Aorta7.07
- Brain - Cortex6.98
- Uterus6.42
- Liver6.34
- Brain - Caudate (basal ganglia)6.03
- Adrenal Gland6
- Prostate5.84
- Brain - Putamen (basal ganglia)5.83
- Brain - Frontal Cortex (BA9)5.67
- Small Intestine - Terminal Ileum5.39
And 29 more, listed on the interactive page.
- GO:0015884
- GO:0046655
- GO:0051958
- GO:0098838
- GO:0140361
- GO:0141111
- GO:0150104
- GO:1904447
- GO:0005886
- GO:0016323
- GO:0016324
- GO:0008517
- GO:0008518
- GO:0015297
- GO:0015350
- GO:0061507
- GO:0140360
Related records
Trials (1,401)
- "Comparing Methotrexate Usage Techniques to Prevent Proliferative Vitreoretinopaty After Retinal Detachment Vitrectomy"
- [CREMA]Combination of R-M Followed by R-A in Elderly Patients With Primary CNS Lymphoma
- 05-001: Treatment of Acute Lymphoblastic Leukemia in Children
- 2-week dc of MTX and Influenza Vaccination in RA
- 4 x Epirubicin, Cyclophosphamide, Followed by 4 x Docetaxel Versus 6 x CMF / 6 x CEF
- 4B951, Combination Chemotherapy in Treating Patients With Bladder Cancer
- 506U78 in Treating Patients With Refractory Hematologic Cancer
- A 30-month Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate in Erosive Hand OA.
- A Bioavailability Study of Methotrexate 25 mg Administered by Needle Injection and a Pre Filled Needle-free Device in Healthy Volunteers.
- A Canadian Study to Evaluate Early Use of Adalimumab After Methotrexate Failure in Early Rheumatoid Arthritis
- A Clinical Research on the Relation of Blood Drug Concentration and Calcium Folinate Rescued in High-dose MTX Therapy
- A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014)
- A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA）
- A Clinical Trial Evaluating Patients With Primary Vitreoretinal Lymphoma
- A Clinical Trial in Patients With Breast Cancer Susceptibility Gene (BRCA) Defective Tumours
- A Clinical Trial of Decitabine in Relapsed or Refractory T-lymphoblastic Lymphoma
- A Clinical Trial of MK-8690 in Participants With Rheumatoid Arthritis (MK-8690-004)
- A Clinical Trial of Safety and Tolerance of TQH3821 Tablets in Adult Healthy Subjects
- A Clinical Trial to Evaluate Effect of IAE0972 Combined with Chemotherapy for R/M HNSCC or NPC(Note: It is Currently Phase II.).
- A Clinical Trial Using Metronomic Oral Low-dose Cyclophosphamide Alternating With Low-dose Oral Methotrexate With Continuous Celecoxib and Weekly Vinblastine in Children and Adolescents With Relapsed or Progressing soliD Tumours.