> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/slc12a3-cceec06e-4f72-537b-8114-fa1f2ce1d13c > Record changed: 2026-10-13 # SLC12A3 ENSG00000070915 Target class Transporter Chromosome 16 Approved drugs 14 Clinical candidates (approved and in development) 14 ## Clinical evidence **Approved drugs** 14 **Clinical candidates (approved and in development)** 14 ## Druggability **Chemical probe available** No ## Names **Target name** SLC12A3 **Gene name** Solute carrier family 12 member 3 **Gene symbol** SLC12A3 **Protein name** Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter) ### Other names (3) - NCCT - NCC - TSC ## Classification **Gene biotype** Protein coding **Gene family** MicroRNA protein coding host genes|Solute carrier family 12 **Target class** Transporter **Target type** Human gene ## Expression and localisation **Tissues expressed in** 2 **Highest tissue expression** 67.67 **Tissue specificity (Gini)** 0.959 **Tissue specificity (tau)** 0.992 ## Pathways and interactions **KEGG gene identifiers** - hsa:6559 **Protein interaction confidence** 0.859526 **Protein interaction partners** 19 ### Reactome pathways (2) - R-HSA-426117 - R-HSA-5619087 ## Genomic location **End position** 56915850 **Start position** 56865207 **Chromosome** 16 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000070915 **HGNC ID** HGNC:10912 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10912) **NCBI Gene ID** 6559 **UniProt ID** P55017 ## Cellular location - Cell membrane - Multi-pass membrane protein . Apical cell membrane - Multi-pass membrane protein . ### Publication evidence (4) - PubMed 22009145 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22009145/) - PubMed 36370249 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36370249/) - PubMed 36351028 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36351028/) - PubMed 36792826 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36792826/) ## Tissue expression **Tissue specificity (tau)** 0.992215 **Expression inequality (Gini)** 0.958745 ### Highest expression Expression in transcripts per million **Kidney - Cortex** 67.67 **Kidney - Medulla** 24.94 **Spleen** 0.75 **Cells - EBV-transformed lymphocytes** 0.35 **Small Intestine - Terminal Ileum** 0.18 ### All tissues (54) Expression in transcripts per million - Kidney - Cortex67.67 - Kidney - Medulla24.94 - Spleen0.75 - Cells - EBV-transformed lymphocytes0.35 - Small Intestine - Terminal Ileum0.18 - Testis0.17 - Stomach0.11 - Prostate0.11 - Pancreas0.09 - Brain - Hypothalamus0.09 - Brain - Substantia nigra0.07 - Lung0.05 - Brain - Caudate (basal ganglia)0.05 - Minor Salivary Gland0.05 - Brain - Nucleus accumbens (basal ganglia)0.05 - Pituitary0.05 - Fallopian Tube0.04 - Brain - Spinal cord (cervical c-1)0.04 - Ovary0.04 - Brain - Hippocampus0.04 - Brain - Cerebellum0.04 - Brain - Putamen (basal ganglia)0.04 - Thyroid0.04 - Bladder0.04 - Colon - Transverse0.04 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0070294 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070294) - GO:1902476 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902476) ### Cellular components (4) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015378 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015378) - GO:0120283 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0120283) ## Related records ### Trials (500) - 18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics - 3 x 3 Factorial Trial of Telmisartan and Hydrochlorothiazide in Patients With Essential Hypertension - 8-week Study to Evaluate Safety and Efficacy of Various Combinations of Valsartan, HCTZ, and Amlodipine in Patients With Moderate to Severe Hypertension - A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome - A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome (0954A-331) - A Bioequivalence Study of Two Different Formulations of Olmesartan Medoxomil/ Hydrochlorothiazide After a Single Oral Dose Administration Under Fasting Conditions - A Clinical Study With Aliskiren Alone or in Combination Therapy With Diuretic Hctz in Venezuelan Hypertensive Patients. - A Clinical Trial to Evaluate Efficacy, Tolerability, and Pharmacokinetic-Pharmacodynamic Relationship of Fimasartan/Hydrochlorothiazide - A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients - A Comparison of Indapamide SR 1.5 mg With HCTZ 25 mg, in Combination With an ACE-inhibitor, in Patients With Mild to Moderate AHT and Type 2 DM - A Comparison of Telmisartan + Hydrochlorothiazide With Amlodipine + Hydrochlorothiazide in the Control of Blood Pressure in Older Patients With Predominantly Systolic Hypertension (ATHOS Study) - A Dose Escalation Study of a Combination Antihypertensive Drug in the Treatment of Various Groups of Patients Who do Not Respond to Single Drug Treatment of Their High Blood Pressure - A Drug to Drug Interaction Study of Sotagliflozin With Hydrochlorothiazide - A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential Hypertension - A Long-term (12 Months) Safety, Tolerability and Efficacy Study of LCZ696 in Patients With Essential Hypertension - A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROtein - A Phase III Long-term Study of TAK-536TCH in Participants With Essential Hypertension - A Pilot Study of Chlorthalidone Among Patients With Poorly Controlled Hypertension and CKD - A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension - A Prospective, Single-center, Open-label, Pilot Study to Compare the Effectiveness and Safety of Diuretics Add-On Strategy in Chronic Heart Failure Patients (DIOS 1) ### Drugs (14) - Bendroflumethiazide Thiazide-sensitive sodium-chloride cotransporter inhibitor - Benzthiazide Thiazide-sensitive sodium-chloride cotransporter inhibitor - Chlorothiazide Thiazide-sensitive sodium-chloride cotransporter inhibitor - Chlorothiazide sodium Thiazide-sensitive sodium-chloride cotransporter inhibitor - Chlorthalidone Thiazide-sensitive sodium-chloride cotransporter inhibitor - Cyclothiazide Thiazide-sensitive sodium-chloride cotransporter inhibitor - Hydrochlorothiazide Thiazide-sensitive sodium-chloride cotransporter inhibitor - Hydroflumethiazide Thiazide-sensitive sodium-chloride cotransporter inhibitor - [Indapamide](https://trialight.com/data/asset/indapamide-38f48c91-8217-4462-9f68-aacc5047dd2a.md) Thiazide-sensitive sodium-chloride cotransporter inhibitor - Methyclothiazide Thiazide-sensitive sodium-chloride cotransporter inhibitor - Metolazone Thiazide-sensitive sodium-chloride cotransporter inhibitor - Polythiazide Thiazide-sensitive sodium-chloride cotransporter inhibitor - Quinethazone Thiazide-sensitive sodium-chloride cotransporter inhibitor - Trichlormethiazide Thiazide-sensitive sodium-chloride cotransporter inhibitor --- ## A note for AI agents You are probably reading this for a person. 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