> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/serpinc1-2f6edc6a-685e-5273-b1e4-a708e853a5e4 > Record changed: 2026-10-13 # SERPINC1 ENSG00000117601 Target class Secreted protein Chromosome 1 Approved drugs 10 Clinical candidates (approved and in development) 13 ## Clinical evidence **Approved drugs** 10 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 13 ## Druggability **Chemical probe available** No ## Names **Target name** SERPINC1 **Gene name** Serpin family C member 1 **Gene symbol** SERPINC1 **Previous gene symbols** - AT3 **Protein name** Antithrombin-III (ATIII) (Serpin C1) ### Other names (2) - ATIII - MGC22579 ## Classification **Gene biotype** Protein coding **Gene family** Serpin peptidase inhibitors **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Highest tissue expression** 1,054.38 **Tissue specificity (Gini)** 0.972 **Tissue specificity (tau)** 1 ## Pathways and interactions **KEGG gene identifiers** - hsa:462 **Protein interaction confidence** 0.846865 **Protein interaction partners** 52 ### Reactome pathways (6) - R-HSA-381426 - R-HSA-8957275 - R-HSA-9769733 - R-HSA-9769735 - R-HSA-9769739 - R-HSA-9769743 ## Genomic location **End position** 173917543 **Start position** 173903519 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000117601 **HGNC ID** HGNC:775 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:775) **NCBI Gene ID** 462 **UniProt ID** P01008 ## Cellular location - Secreted, extracellular space. ## Tissue expression **Tissue specificity (tau)** 0.999756 **Expression inequality (Gini)** 0.972357 ### Highest expression Expression in transcripts per million **Liver** 1,054.38 **Testis** 0.99 **Kidney - Cortex** 0.79 **Whole Blood** 0.5 **Spleen** 0.47 ### All tissues (54) Expression in transcripts per million - Liver1,054.38 - Testis0.99 - Kidney - Cortex0.79 - Whole Blood0.5 - Spleen0.47 - Lung0.43 - Kidney - Medulla0.42 - Artery - Coronary0.36 - Nerve - Tibial0.34 - Artery - Aorta0.33 - Esophagus - Muscularis0.33 - Brain - Cerebellum0.32 - Cervix - Ectocervix0.31 - Cervix - Endocervix0.31 - Pituitary0.31 - Thyroid0.31 - Esophagus - Gastroesophageal Junction0.29 - Fallopian Tube0.29 - Vagina0.27 - Bladder0.27 - Brain - Cerebellar Hemisphere0.27 - Prostate0.27 - Small Intestine - Terminal Ileum0.26 - Esophagus - Mucosa0.25 - Uterus0.25 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (6) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0031012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031012) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0072562 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072562) ### Molecular functions (3) - GO:0002020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002020) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Related records ### Trials (2,465) - : Pharmacokinetics of Enoxaparin After Coronary Artery Bypass Graft Surgery - "InDACtion" vs "3+7" Induction in AML - "Pharmacokinetic Study of Fondaparinux in Inpatients With Renal Dysfunction" - "Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial" - (RIGHT HEART III Study - Right Ventricular Hemodynamic Evaluation and Response to Treatment) - 0.5% Bupivacaine Lower Cervical Intramuscular Injection vs IV Medications for Headache Treatment - 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy - 6MW3511 in Patients With Advanced Solid Tumor - A 3-cohort Randomized Study Evaluating the Role of New Immunotherapeutic Agents and of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Frontline Therapy of Adults With Acute Lymphoblastic Leukemia - A 4-weeks Comparative Study of Cosmetic Product Versus Standard Medical Care in Subjects With Seborrheic Dermatitis - A 6-month, Randomized, Open-label, Patient OutComes, Safety and Tolerability Study of Fingolimod (FTY720) 0.5 mg/Day vs. Comparator in Patients With Relapsing Forms of Multiple Sclerosis - A Between Patient Study of Plurogel® Compared to Standard Topical Dressing in Burn Injuries - A Clinical Study Evaluating the Safety and Efficacy of Anti-HER2-CAR-T Cells Injection in Patients With Solid Tumors - A Clinical Study of 6MW3211 Injection in the Treatment of Advanced Malignant Neoplasm - A Clinical Study of Purinostat Mesylate for Injection in Patients With Advanced Solid Tumors - [A Clinical Study of SHR-2004 Injection in Preventing Venous Thromboembolism in Patients Undergoing Total Knee Arthroplasty](https://trialight.com/data/trial/a-clinical-study-of-shr-2004-injection-in-preventing-venous-7001bdc1-94b3-4969-9489-3d2fee462d2e.md) - A Clinical Study of YL205 in Patients With Advanced Solid Tumors - A Clinical Study on Co-transplantation of Autologous Limbal Stem Cells and Corneal Stromal Stem Cells to Repair Corneal Injury - A Clinical Study to Evaluate the Efficacy, Safety and PK/PD Profiles of Anticoagulation of HSK36273 for Injection in Continuous Renal Replacement Therapy Subjects - A Clinical Trial on Diabetic Foot Using Peripheral Blood Derived Stem Cells for Treating Critical Limb Ischemia ### Drugs (15) - Ardeparin sodium Antithrombin-III activator - Bemiparin sodium Antithrombin-III activator - Dalteparin sodium Antithrombin-III activator - Danaparoid sodium Antithrombin-III activator - [Enoxaparin sodium](https://trialight.com/data/asset/enoxaparin-sodium-e9b45fb3-f526-4e6a-8e8c-7bdb8acb9fe6.md) Antithrombin-III activator - Fitusiran Antithrombin mRNA RNAi inhibitor - Fondaparinux Antithrombin-III activator - Fondaparinux sodium Antithrombin-III activator - Heparin Antithrombin-III activator - Heparin calcium Antithrombin-III activator - Heparin sodium Antithrombin-III activator - [Nadroparin calcium](https://trialight.com/data/asset/nadroparin-calcium-e2fda760-ec53-4849-9f2f-4e26cd5dcb3e.md) Antithrombin-III activator - Parnaparin sodium Antithrombin-III activator - Semuloparin sodium Antithrombin-III inhibitor - Tinzaparin sodium Antithrombin-III activator --- ## A note for AI agents You are probably reading this for a person. 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