SCN9A
ENSG00000169432
Target class
Ion channel
Chromosome
2
Approved drugs
51
Clinical candidates (approved and in development)
64
- Approved drugs
- 51
- ClinGen gene-disease validity
- Refuted
- Clinical candidates (approved and in development)
- 64
- Chemical probe available
- Yes
- Target name
- SCN9A
- Gene name
- Sodium voltage-gated channel alpha subunit 9
- Gene symbol
- SCN9A
- Protein name
- Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7)
- Nav1.7
- PN1
- NE-NA
- NENA
- ETHA
- Gene biotype
- Protein coding
- Gene family
- Sodium voltage-gated channel alpha subunits
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 23
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 8.94
- Tissue specificity (Gini)
- 0.57
- Tissue specificity (tau)
- 0.843
- KEGG gene identifiers
- hsa:6335
- Protein interaction confidence
- 0.807875
- Protein interaction partners
- 24
- R-HSA-445095
- R-HSA-5576892
- R-HSA-9717207
- End position
- 166376001
- Start position
- 166195185
- Chromosome
- 2
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein . Cell projection, neuron projection . Cell projection, axon . Note=Localizes to neuron terminals (PubMed:30765606, PubMed:30795902). Also detected at Nodes of Ranvier (PubMed:30795902). .
- Actin filaments
- Focal adhesion sites
- Plasma membrane
- PubMed 15385606
- PubMed 17167479
- PubMed 19369487
- PubMed 24311784
- PubMed 25240195
- PubMed 26680203
- PubMed 7720699
- PubMed 30765606
- PubMed 30795902
- Tissue specificity (tau)
- 0.842704
- Expression inequality (Gini)
- 0.569664
Expression in transcripts per million
- Testis
- 8.94
- Nerve - Tibial
- 8.91
- Brain - Hypothalamus
- 7.51
- Colon - Sigmoid
- 6.29
- Spleen
- 5.3
Expression in transcripts per million
- Testis8.94
- Nerve - Tibial8.91
- Brain - Hypothalamus7.51
- Colon - Sigmoid6.29
- Spleen5.3
- Colon - Transverse4.24
- Pituitary3.24
- Liver2.08
- Cells - Cultured fibroblasts2.03
- Brain - Nucleus accumbens (basal ganglia)1.99
- Esophagus - Gastroesophageal Junction1.9
- Esophagus - Muscularis1.78
- Lung1.73
- Small Intestine - Terminal Ileum1.55
- Brain - Substantia nigra1.43
- Adipose - Subcutaneous1.4
- Adipose - Visceral (Omentum)1.3
- Brain - Amygdala1.29
- Pancreas1.28
- Brain - Anterior cingulate cortex (BA24)1.07
- Cervix - Endocervix1.05
- Artery - Coronary1.03
- Cervix - Ectocervix1
- Brain - Caudate (basal ganglia)0.98
- Brain - Spinal cord (cervical c-1)0.96
And 29 more, listed on the interactive page.
- GO:0019228
- GO:0019233
- GO:0086010
- GO:0098870
- GO:0005886
- GO:0033268
- GO:0043679
- GO:0005248
- GO:0005515
Related records
Trials (4,191)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy"
- "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"
- "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
- "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy")
- [64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy
- ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis
- 1% Chloroprocaine(PF) vs. Bupivacaine Spinals
- 1% Lidocaine Paracervical Block for Endometrial Biopsy
- 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
- 1% vs. 2 % Lignocaine for Flexible Bronchoscopy
- 10% Lidocaine Spray for Intrauterine Device Insertion
- 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
- 2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy
- 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy
- 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula
- 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
- 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions
Drugs (89)
- Articaine Sodium channel alpha subunit blocker
- Articaine hydrochloride Sodium channel alpha subunit blocker
- AZD3161 Sodium channel protein type IX alpha subunit blocker
- Benoxinate Sodium channel alpha subunit blocker
- Benoxinate hydrochloride Sodium channel alpha subunit blocker
- Carbamazepine Sodium channel alpha subunit blocker
- Cenobamate Sodium channel alpha subunit inhibitor
- Chloroprocaine Sodium channel alpha subunit blocker
- Chloroprocaine hydrochloride Sodium channel alpha subunit blocker
- Cocaine Sodium channel alpha subunit blocker
- Cocaine hydrochloride Sodium channel alpha subunit blocker
- Disopyramide Sodium channel alpha subunit blocker
- Disopyramide phosphate Sodium channel alpha subunit blocker
- Dronedarone Sodium channel alpha subunit blocker
- Dronedarone hydrochloride Sodium channel alpha subunit blocker
- DSP-2230 Sodium channel protein type IX alpha subunit blocker
- Dyclonine Sodium channel alpha subunit blocker
- Dyclonine hydrochloride Sodium channel alpha subunit blocker
- Encainide Sodium channel alpha subunit blocker
- Encainide hydrochloride Sodium channel alpha subunit blocker