SCN8A
ENSG00000196876
Target class
Ion channel
Chromosome
12
Approved drugs
51
Clinical candidates (approved and in development)
58
- Approved drugs
- 51
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 58
- Chemical probe available
- No
- Target name
- SCN8A
- Gene name
- Sodium voltage-gated channel alpha subunit 8
- Gene symbol
- SCN8A
- Previous gene symbols
- MED
- Protein name
- Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)
- Nav1.6
- NaCh6
- PN4
- CerIII
- CIAT
- Gene biotype
- Protein coding
- Gene family
- Sodium voltage-gated channel alpha subunits
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 18
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 28.22
- Tissue specificity (Gini)
- 0.759
- Tissue specificity (tau)
- 0.91
- KEGG gene identifiers
- hsa:6334
- Protein interaction confidence
- 0.824412
- Protein interaction partners
- 34
- R-HSA-445095
- R-HSA-5576892
- End position
- 51812864
- Start position
- 51590266
- Chromosome
- 12
- Strand
- Forward
- Cell membrane
- Multi-pass membrane protein . Cell projection, axon . Note=Mainly localizes to the axon initial segment. .
- SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasmic vesicle . Cell projection, podosome .
- Cell Junctions
- Plasma membrane
- Vesicles
- PubMed 29726066
- PubMed 36696443
- PubMed 36823201
- PubMed 19136557
- Tissue specificity (tau)
- 0.91024
- Expression inequality (Gini)
- 0.759403
Expression in transcripts per million
- Brain - Cerebellum
- 28.22
- Brain - Cerebellar Hemisphere
- 26.37
- Brain - Frontal Cortex (BA9)
- 17.89
- Brain - Cortex
- 14.83
- Pituitary
- 10.94
Expression in transcripts per million
- Brain - Cerebellum28.22
- Brain - Cerebellar Hemisphere26.37
- Brain - Frontal Cortex (BA9)17.89
- Brain - Cortex14.83
- Pituitary10.94
- Cells - Cultured fibroblasts8.1
- Brain - Anterior cingulate cortex (BA24)7.55
- Brain - Nucleus accumbens (basal ganglia)6.56
- Brain - Caudate (basal ganglia)5.34
- Brain - Hippocampus5
- Brain - Putamen (basal ganglia)4.21
- Brain - Hypothalamus3.88
- Brain - Amygdala2.97
- Testis2.58
- Brain - Substantia nigra1.65
- Liver1.41
- Brain - Spinal cord (cervical c-1)1.33
- Prostate1.01
- Pancreas0.81
- Spleen0.78
- Cervix - Endocervix0.71
- Ovary0.69
- Colon - Transverse0.68
- Kidney - Cortex0.62
- Thyroid0.61
And 29 more, listed on the interactive page.
- GO:0001508
- GO:0086010
- GO:0001518
- GO:0005886
- GO:0016020
- GO:0031410
- GO:0005248
- GO:0005515
- GO:0031402
Related records
Trials (4,162)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy"
- "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"
- "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
- "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy")
- [64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy
- ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis
- 1% Chloroprocaine(PF) vs. Bupivacaine Spinals
- 1% Lidocaine Paracervical Block for Endometrial Biopsy
- 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
- 1% vs. 2 % Lignocaine for Flexible Bronchoscopy
- 10% Lidocaine Spray for Intrauterine Device Insertion
- 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
- 2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy
- 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy
- 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula
- 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
- 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions
Drugs (83)
- Articaine Sodium channel alpha subunit blocker
- Articaine hydrochloride Sodium channel alpha subunit blocker
- Benoxinate Sodium channel alpha subunit blocker
- Benoxinate hydrochloride Sodium channel alpha subunit blocker
- Carbamazepine Sodium channel alpha subunit blocker
- Cenobamate Sodium channel alpha subunit inhibitor
- Chloroprocaine Sodium channel alpha subunit blocker
- Chloroprocaine hydrochloride Sodium channel alpha subunit blocker
- Cocaine Sodium channel alpha subunit blocker
- Cocaine hydrochloride Sodium channel alpha subunit blocker
- Disopyramide Sodium channel alpha subunit blocker
- Disopyramide phosphate Sodium channel alpha subunit blocker
- Dronedarone Sodium channel alpha subunit blocker
- Dronedarone hydrochloride Sodium channel alpha subunit blocker
- Dyclonine Sodium channel alpha subunit blocker
- Dyclonine hydrochloride Sodium channel alpha subunit blocker
- Encainide Sodium channel alpha subunit blocker
- Encainide hydrochloride Sodium channel alpha subunit blocker
- Eslicarbazepine Sodium channel alpha subunit blocker
- Eslicarbazepine acetate Sodium channel alpha subunit blocker