SCN7A
ENSG00000136546
Target class
Ion channel
Chromosome
2
Approved drugs
51
Clinical candidates (approved and in development)
57
- Approved drugs
- 51
- Clinical candidates (approved and in development)
- 57
- Chemical probe available
- No
- Target name
- SCN7A
- Gene name
- Sodium voltage-gated channel alpha subunit 7
- Gene symbol
- SCN7A
- Previous gene symbols
- SCN6A
- Protein name
- Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha)
- Nav2.1
- Nav2.2
- NaG
- Gene biotype
- Protein coding
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 38
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 143.22
- Tissue specificity (Gini)
- 0.75
- Tissue specificity (tau)
- 0.935
- KEGG gene identifiers
- hsa:6332
- Protein interaction confidence
- 0.886667
- Protein interaction partners
- 12
- R-HSA-445095
- R-HSA-5576892
- End position
- 166611482
- Start position
- 166403472
- Chromosome
- 2
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein .
- Plasma membrane
Publication evidence
- PubMed 35301303
- Tissue specificity (tau)
- 0.935075
- Expression inequality (Gini)
- 0.750174
Expression in transcripts per million
- Nerve - Tibial
- 143.22
- Ovary
- 70.36
- Colon - Sigmoid
- 64.29
- Lung
- 54.41
- Esophagus - Muscularis
- 45.75
Expression in transcripts per million
- Nerve - Tibial143.22
- Ovary70.36
- Colon - Sigmoid64.29
- Lung54.41
- Esophagus - Muscularis45.75
- Esophagus - Gastroesophageal Junction42.83
- Fallopian Tube22.16
- Uterus18.95
- Colon - Transverse17.2
- Prostate16.3
- Cervix - Endocervix13.45
- Heart - Atrial Appendage12.01
- Artery - Coronary11.38
- Cervix - Ectocervix11.21
- Heart - Left Ventricle9.99
- Vagina9.01
- Bladder7.57
- Small Intestine - Terminal Ileum5.47
- Breast - Mammary Tissue5.02
- Minor Salivary Gland4.56
- Testis4.34
- Esophagus - Mucosa4.28
- Brain - Hypothalamus4.08
- Stomach3.34
- Adrenal Gland2.95
And 29 more, listed on the interactive page.
Biological processes
- GO:0055078
- GO:0005272
- GO:0005515
Related records
Trials (4,157)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy"
- "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"
- "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
- "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy")
- [64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy
- ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis
- 1% Chloroprocaine(PF) vs. Bupivacaine Spinals
- 1% Lidocaine Paracervical Block for Endometrial Biopsy
- 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
- 1% vs. 2 % Lignocaine for Flexible Bronchoscopy
- 10% Lidocaine Spray for Intrauterine Device Insertion
- 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
- 2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy
- 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy
- 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula
- 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
- 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions
Drugs (82)
- Articaine Sodium channel alpha subunit blocker
- Articaine hydrochloride Sodium channel alpha subunit blocker
- Benoxinate Sodium channel alpha subunit blocker
- Benoxinate hydrochloride Sodium channel alpha subunit blocker
- Carbamazepine Sodium channel alpha subunit blocker
- Cenobamate Sodium channel alpha subunit inhibitor
- Chloroprocaine Sodium channel alpha subunit blocker
- Chloroprocaine hydrochloride Sodium channel alpha subunit blocker
- Cocaine Sodium channel alpha subunit blocker
- Cocaine hydrochloride Sodium channel alpha subunit blocker
- Disopyramide Sodium channel alpha subunit blocker
- Disopyramide phosphate Sodium channel alpha subunit blocker
- Dronedarone Sodium channel alpha subunit blocker
- Dronedarone hydrochloride Sodium channel alpha subunit blocker
- Dyclonine Sodium channel alpha subunit blocker
- Dyclonine hydrochloride Sodium channel alpha subunit blocker
- Encainide Sodium channel alpha subunit blocker
- Encainide hydrochloride Sodium channel alpha subunit blocker
- Eslicarbazepine Sodium channel alpha subunit blocker
- Eslicarbazepine acetate Sodium channel alpha subunit blocker