> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/scn5a-b122849c-977b-5d4c-a790-0245f1654eb5 > Record changed: 2026-10-13 # SCN5A ENSG00000183873 Target class Ion channel Chromosome 3 Approved drugs 56 Clinical candidates (approved and in development) 64 ## Clinical evidence **Approved drugs** 56 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 64 ## Druggability **Chemical probe available** No ## Names **Target name** SCN5A **Gene name** Sodium voltage-gated channel alpha subunit 5 **Gene symbol** SCN5A **Previous gene symbols** - CMD1E **Protein name** Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) ### Other names (12) - Nav1.5 - LQT3 - HB1 - HBBD - PFHB1 - IVF - HB2 - HH1 - SSS1 - CDCD2 - CMPD2 - ICCD ## Classification **Gene biotype** Protein coding **Gene family** Sodium voltage-gated channel alpha subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 8 **Protein localisation evidence grade** Supported **Highest tissue expression** 36.13 **Tissue specificity (Gini)** 0.833 **Tissue specificity (tau)** 0.965 ## Pathways and interactions **KEGG gene identifiers** - hsa:6331 **Protein interaction confidence** 0.858519 **Protein interaction partners** 77 ### Reactome pathways (2) - R-HSA-445095 - R-HSA-5576892 ## Genomic location **End position** 38649743 **Start position** 38548057 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000183873 **HGNC ID** HGNC:10593 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10593) **NCBI Gene ID** 6331 **UniProt ID** Q14524 ## Cellular location - Cell membrane - Multi-pass membrane protein . Cytoplasm, perinuclear region . Cell membrane, sarcolemma, T-tubule . Cell junction . Note=RANGRF promotes trafficking to the cell membrane. Colocalizes with PKP2 at intercalated disks in the heart (By similarity). . - Nucleoli - Nucleoplasm - Plasma membrane ### Publication evidence (7) - PubMed 1309946 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1309946/) - PubMed 19074138 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19074138/) - PubMed 21447824 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21447824/) - PubMed 23085483 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23085483/) - PubMed 23420830 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23420830/) - PubMed 25370050 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25370050/) - PubMed 26279430 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26279430/) ## Tissue expression **Tissue specificity (tau)** 0.964546 **Expression inequality (Gini)** 0.833109 ### Highest expression Expression in transcripts per million **Heart - Atrial Appendage** 36.13 **Heart - Left Ventricle** 35.11 **Cervix - Ectocervix** 5.35 **Cervix - Endocervix** 4.12 **Nerve - Tibial** 2.92 ### All tissues (54) Expression in transcripts per million - Heart - Atrial Appendage36.13 - Heart - Left Ventricle35.11 - Cervix - Ectocervix5.35 - Cervix - Endocervix4.12 - Nerve - Tibial2.92 - Artery - Aorta1.86 - Vagina1.83 - Ovary1.53 - Prostate0.99 - Uterus0.87 - Bladder0.86 - Artery - Tibial0.81 - Colon - Sigmoid0.76 - Brain - Hypothalamus0.76 - Testis0.74 - Brain - Cortex0.64 - Brain - Frontal Cortex (BA9)0.5 - Muscle - Skeletal0.47 - Breast - Mammary Tissue0.46 - Pituitary0.46 - Artery - Coronary0.45 - Fallopian Tube0.43 - Thyroid0.4 - Esophagus - Muscularis0.38 - Colon - Transverse0.37 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (28) - GO:0002027 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002027) - GO:0006814 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006814) - GO:0010765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010765) - GO:0035725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035725) - GO:0051899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051899) - GO:0060048 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060048) - GO:0060307 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060307) - GO:0060371 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060371) - GO:0060372 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060372) - GO:0060373 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060373) - GO:0071277 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071277) - GO:0086002 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086002) - GO:0086004 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086004) - GO:0086005 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086005) - GO:0086010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086010) - GO:0086012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086012) - GO:0086014 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086014) - GO:0086015 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086015) - GO:0086016 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086016) - GO:0086043 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086043) - GO:0086045 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086045) - GO:0086046 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086046) - GO:0086047 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086047) - GO:0086048 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086048) - GO:0086067 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086067) And 3 more, listed on the interactive page. ### Cellular components (11) - GO:0001518 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001518) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005901) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0014704 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014704) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0016328 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016328) - GO:0030018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030018) - GO:0030315 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030315) - GO:0042383 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042383) ### Molecular functions (17) - GO:0005248 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005248) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005516 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005516) - GO:0017134 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017134) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0019904 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019904) - GO:0030506 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030506) - GO:0031625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031625) - GO:0044325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044325) - GO:0050998 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050998) - GO:0086006 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086006) - GO:0086060 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086060) - GO:0086061 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086061) - GO:0086062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086062) - GO:0086063 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086063) - GO:0097110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097110) ## On-target safety - TdP ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: TdP ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - polymorphic ventricular tachycardia ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: polymorphic ventricular tachycardia ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - arrhythmias ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: arrhythmias ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - long QT ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: long QT ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) ## Off-target safety - prolonged QRS interval of ECG ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: prolonged QRS interval of ECG ### Biological samples - cardiovascular system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - slowed cardiac conduction ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: slowed cardiac conduction ### Biological samples - cardiovascular system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) ## Related records ### Trials (4,295) - : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic - "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy" - "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome" - "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age." - "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy") - \[64Cu\]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy - ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis - 1% Chloroprocaine(PF) vs. Bupivacaine Spinals - 1% Lidocaine Paracervical Block for Endometrial Biopsy - 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration - 1% vs. 2 % Lignocaine for Flexible Bronchoscopy - 10% Lidocaine Spray for Intrauterine Device Insertion - 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression - 2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy - 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy - 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula - 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study - 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty - 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis - 4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions ### Drugs (92) - Articaine Sodium channel alpha subunit blocker - Articaine hydrochloride Sodium channel alpha subunit blocker - AZD1305 Sodium channel protein type V alpha subunit blocker - AZD7009 Sodium channel protein type V alpha subunit blocker - Benoxinate Sodium channel alpha subunit blocker - Benoxinate hydrochloride Sodium channel alpha subunit blocker - Carbamazepine Sodium channel alpha subunit blocker - Cenobamate Sodium channel alpha subunit inhibitor - Chloroprocaine Sodium channel alpha subunit blocker - Chloroprocaine hydrochloride Sodium channel alpha subunit blocker - Cocaine Sodium channel alpha subunit blocker - Cocaine hydrochloride Sodium channel alpha subunit blocker - Dibucaine Sodium channel protein type V alpha subunit blocker - Dibucaine hydrochloride Sodium channel protein type V alpha subunit blocker - Disopyramide Sodium channel alpha subunit blocker - Disopyramide phosphate Sodium channel alpha subunit blocker - Dronedarone Sodium channel alpha subunit blocker - Dronedarone hydrochloride Sodium channel alpha subunit blocker - Dyclonine Sodium channel alpha subunit blocker - Dyclonine hydrochloride Sodium channel alpha subunit blocker --- ## A note for AI agents You are probably reading this for a person. 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