> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/scn4a-49bb6125-30fd-58f5-8275-868382aee1cb > Record changed: 2026-10-13 # SCN4A ENSG00000007314 Target class Ion channel Chromosome 17 Approved drugs 55 Clinical candidates (approved and in development) 61 ## Clinical evidence **Approved drugs** 55 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 61 ## Druggability **Chemical probe available** No ## Names **Target name** SCN4A **Gene name** Sodium voltage-gated channel alpha subunit 4 **Gene symbol** SCN4A **Previous gene symbols** - HYKPP **Protein name** Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) ### Other names (3) - Nav1.4 - HYPP - SkM1 ## Classification **Gene biotype** Protein coding **Gene family** Sodium voltage-gated channel alpha subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 12 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 80.71 **Tissue specificity (Gini)** 0.862 **Tissue specificity (tau)** 0.975 ## Pathways and interactions **KEGG gene identifiers** - hsa:6329 **Protein interaction confidence** 0.843516 **Protein interaction partners** 31 ### Reactome pathways (2) - R-HSA-445095 - R-HSA-5576892 ## Genomic location **End position** 63972918 **Start position** 63938554 **Chromosome** 17 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000007314 **HGNC ID** HGNC:10591 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10591) **NCBI Gene ID** 6329 **UniProt ID** P35499 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (11) - PubMed 12766226 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12766226/) - PubMed 15318338 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15318338/) - PubMed 16890191 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16890191/) - PubMed 17898326 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17898326/) - PubMed 18690054 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18690054/) - PubMed 19347921 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19347921/) - PubMed 25707578 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25707578/) - PubMed 26659129 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26659129/) - PubMed 26700687 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26700687/) - PubMed 29992740 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29992740/) - PubMed 30190309 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30190309/) ## Tissue expression **Tissue specificity (tau)** 0.974598 **Expression inequality (Gini)** 0.861708 ### Highest expression Expression in transcripts per million **Muscle - Skeletal** 80.71 **Adipose - Visceral (Omentum)** 29.95 **Breast - Mammary Tissue** 20.96 **Adipose - Subcutaneous** 18.13 **Thyroid** 10.4 ### All tissues (54) Expression in transcripts per million - Muscle - Skeletal80.71 - Adipose - Visceral (Omentum)29.95 - Breast - Mammary Tissue20.96 - Adipose - Subcutaneous18.13 - Thyroid10.4 - Testis4.54 - Pituitary3.33 - Colon - Sigmoid1.63 - Spleen1.58 - Kidney - Medulla1.43 - Artery - Coronary1.42 - Skin - Sun Exposed (Lower leg)1 - Nerve - Tibial0.99 - Minor Salivary Gland0.83 - Skin - Not Sun Exposed (Suprapubic)0.73 - Adrenal Gland0.72 - Heart - Atrial Appendage0.71 - Ovary0.68 - Stomach0.63 - Artery - Tibial0.61 - Colon - Transverse0.59 - Bladder0.59 - Artery - Aorta0.56 - Prostate0.52 - Small Intestine - Terminal Ileum0.5 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0006814 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006814) - GO:0006936 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006936) - GO:0035725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035725) - GO:0100001 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0100001) ### Cellular components (2) - GO:0001518 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001518) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (2) - GO:0005248 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005248) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (5,816) - : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic - "Analgesic Efficacy of Combined Transversus Abdominis Plane Block and Posterior Rectus Sheath Block in Patients Undergoing Laparoscopic Appendectomy" - "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy" - "Dexa vs Dexmedetomidine With Bupivacaine in TAP Block for Laparotomy Analgesia - "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome" - "Efficacy of Local Anesthetic for Postoperative Pain in Gynecologic Laparoscopy" - "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age." - "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy") - "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors" - (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes - \[64Cu\]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy - ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis - 0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka - 0.5% Bupivacaine Lower Cervical Intramuscular Injection vs IV Medications for Headache Treatment - 1% Chloroprocaine(PF) vs. Bupivacaine Spinals - 1% Lidocaine Paracervical Block for Endometrial Biopsy - 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration - 1% vs. 2 % Lignocaine for Flexible Bronchoscopy - 10% Lidocaine Spray for Intrauterine Device Insertion - 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression ### Drugs (87) - Articaine Sodium channel alpha subunit blocker - Articaine hydrochloride Sodium channel alpha subunit blocker - Benoxinate Sodium channel alpha subunit blocker - Benoxinate hydrochloride Sodium channel alpha subunit blocker - Bupivacaine Sodium channel protein type IV alpha subunit blocker - Bupivacaine hydrochloride Sodium channel protein type IV alpha subunit blocker - Carbamazepine Sodium channel alpha subunit blocker - Cenobamate Sodium channel alpha subunit inhibitor - Chloroprocaine Sodium channel alpha subunit blocker - Chloroprocaine hydrochloride Sodium channel alpha subunit blocker - Cocaine Sodium channel alpha subunit blocker - Cocaine hydrochloride Sodium channel alpha subunit blocker - Disopyramide Sodium channel alpha subunit blocker - Disopyramide phosphate Sodium channel alpha subunit blocker - Dronedarone Sodium channel alpha subunit blocker - Dronedarone hydrochloride Sodium channel alpha subunit blocker - Dyclonine Sodium channel alpha subunit blocker - Dyclonine hydrochloride Sodium channel alpha subunit blocker - Encainide Sodium channel alpha subunit blocker - Encainide hydrochloride Sodium channel alpha subunit blocker --- ## A note for AI agents You are probably reading this for a person. 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