SCN3A
ENSG00000153253
Target class
Ion channel
Chromosome
2
Approved drugs
51
Clinical candidates (approved and in development)
58
- Approved drugs
- 51
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 58
- Chemical probe available
- No
- Other names
- Nav1.3
- Target name
- SCN3A
- Gene name
- Sodium voltage-gated channel alpha subunit 3
- Gene symbol
- SCN3A
- Protein name
- Sodium channel protein type 3 subunit alpha (Sodium channel protein brain III subunit alpha) (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subtype III) (Voltage-gated sodium channel subunit alpha Nav1.3)
- Gene biotype
- Protein coding
- Gene family
- Sodium voltage-gated channel alpha subunits
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 26
- Highest tissue expression
- 12.98
- Tissue specificity (Gini)
- 0.604
- Tissue specificity (tau)
- 0.84
- KEGG gene identifiers
- hsa:6328
- Protein interaction confidence
- 0.849
- Protein interaction partners
- 15
- R-HSA-445095
- R-HSA-5576892
- R-HSA-9717207
- End position
- 165204050
- Start position
- 165087526
- Chromosome
- 2
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein . Basal cell membrane
- Multi-pass membrane protein . Note=In enterochromaffin cells, localized highly asymmetrically, almost exclusively at the basal side. .
- PubMed 28235671
- PubMed 35277491
- Tissue specificity (tau)
- 0.840015
- Expression inequality (Gini)
- 0.604272
Expression in transcripts per million
- Brain - Cerebellar Hemisphere
- 12.98
- Brain - Cerebellum
- 11.34
- Brain - Hypothalamus
- 9.29
- Brain - Nucleus accumbens (basal ganglia)
- 8.5
- Pituitary
- 8.07
Expression in transcripts per million
- Brain - Cerebellar Hemisphere12.98
- Brain - Cerebellum11.34
- Brain - Hypothalamus9.29
- Brain - Nucleus accumbens (basal ganglia)8.5
- Pituitary8.07
- Brain - Frontal Cortex (BA9)6.45
- Brain - Cortex5.76
- Brain - Anterior cingulate cortex (BA24)5.21
- Brain - Caudate (basal ganglia)5.14
- Brain - Amygdala3.93
- Brain - Putamen (basal ganglia)3.45
- Brain - Hippocampus3.38
- Testis3.22
- Brain - Substantia nigra3.04
- Artery - Coronary2.63
- Brain - Spinal cord (cervical c-1)2.12
- Thyroid1.96
- Artery - Tibial1.73
- Adipose - Subcutaneous1.73
- Nerve - Tibial1.68
- Artery - Aorta1.54
- Uterus1.41
- Adipose - Visceral (Omentum)1.31
- Small Intestine - Terminal Ileum1.27
- Breast - Mammary Tissue1.26
And 29 more, listed on the interactive page.
Biological processes
- GO:0086010
- GO:0001518
- GO:0005886
Molecular functions
- GO:0005248
Related records
Trials (4,157)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy"
- "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"
- "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
- "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy")
- [64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy
- ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis
- 1% Chloroprocaine(PF) vs. Bupivacaine Spinals
- 1% Lidocaine Paracervical Block for Endometrial Biopsy
- 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
- 1% vs. 2 % Lignocaine for Flexible Bronchoscopy
- 10% Lidocaine Spray for Intrauterine Device Insertion
- 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
- 2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy
- 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy
- 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula
- 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
- 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions
Drugs (83)
- Articaine Sodium channel alpha subunit blocker
- Articaine hydrochloride Sodium channel alpha subunit blocker
- Benoxinate Sodium channel alpha subunit blocker
- Benoxinate hydrochloride Sodium channel alpha subunit blocker
- Carbamazepine Sodium channel alpha subunit blocker
- Cenobamate Sodium channel alpha subunit inhibitor
- Chloroprocaine Sodium channel alpha subunit blocker
- Chloroprocaine hydrochloride Sodium channel alpha subunit blocker
- Cocaine Sodium channel alpha subunit blocker
- Cocaine hydrochloride Sodium channel alpha subunit blocker
- Disopyramide Sodium channel alpha subunit blocker
- Disopyramide phosphate Sodium channel alpha subunit blocker
- Dronedarone Sodium channel alpha subunit blocker
- Dronedarone hydrochloride Sodium channel alpha subunit blocker
- Dyclonine Sodium channel alpha subunit blocker
- Dyclonine hydrochloride Sodium channel alpha subunit blocker
- Elpetrigine Sodium channel protein type III alpha subunit blocker
- Encainide Sodium channel alpha subunit blocker
- Encainide hydrochloride Sodium channel alpha subunit blocker
- Eslicarbazepine Sodium channel alpha subunit blocker