> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/scn2a-58945297-e1b4-5bf0-977c-fff5460c4bc5 > Record changed: 2026-10-13 # SCN2A ENSG00000136531 Target class Ion channel Chromosome 2 Approved drugs 51 Clinical candidates (approved and in development) 58 ## Clinical evidence **Approved drugs** 51 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 58 ## Druggability **Chemical probe available** Yes ## Names **Target name** SCN2A **Gene name** Sodium voltage-gated channel alpha subunit 2 **Gene symbol** SCN2A **Protein name** Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) ### Other names (3) - Nav1.2 - HBSCII - HBSCI ### Previous gene symbols (2) - SCN2A1 - SCN2A2 ## Classification **Gene biotype** Protein coding **Gene family** Sodium voltage-gated channel alpha subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 16 **Highest tissue expression** 70.28 **Tissue specificity (Gini)** 0.866 **Tissue specificity (tau)** 0.958 ## Pathways and interactions **KEGG gene identifiers** - hsa:6326 **Protein interaction confidence** 0.837104 **Protein interaction partners** 48 ### Reactome pathways (3) - R-HSA-445095 - R-HSA-5576892 - R-HSA-9717207 ## Genomic location **End position** 165392310 **Start position** 165194993 **Chromosome** 2 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000136531 **HGNC ID** HGNC:10588 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10588) **NCBI Gene ID** 6326 **UniProt ID** Q99250 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 1325650 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1325650/) - PubMed 17021166 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17021166/) - PubMed 29844171 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29844171/) ## Tissue expression **Tissue specificity (tau)** 0.957834 **Expression inequality (Gini)** 0.865603 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 70.28 **Brain - Cerebellum** 65.2 **Brain - Frontal Cortex (BA9)** 19.28 **Brain - Cortex** 11.46 **Brain - Nucleus accumbens (basal ganglia)** 9.12 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere70.28 - Brain - Cerebellum65.2 - Brain - Frontal Cortex (BA9)19.28 - Brain - Cortex11.46 - Brain - Nucleus accumbens (basal ganglia)9.12 - Brain - Anterior cingulate cortex (BA24)8.35 - Brain - Caudate (basal ganglia)6.56 - Brain - Hypothalamus6.15 - Brain - Hippocampus5.15 - Brain - Putamen (basal ganglia)4.8 - Pituitary4.22 - Brain - Amygdala4.21 - Kidney - Cortex1.98 - Brain - Substantia nigra1.77 - Kidney - Medulla1.55 - Brain - Spinal cord (cervical c-1)1.39 - Nerve - Tibial0.66 - Uterus0.49 - Testis0.36 - Vagina0.35 - Cervix - Endocervix0.31 - Artery - Coronary0.29 - Cervix - Ectocervix0.28 - Adrenal Gland0.26 - Ovary0.24 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0019228 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019228) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0030424 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030424) ### Molecular functions (3) - GO:0005248 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005248) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005516 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005516) ## Related records ### Trials (4,157) - : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic - "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy" - "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome" - "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age." - "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy") - \[64Cu\]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy - ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis - 1% Chloroprocaine(PF) vs. Bupivacaine Spinals - 1% Lidocaine Paracervical Block for Endometrial Biopsy - 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration - 1% vs. 2 % Lignocaine for Flexible Bronchoscopy - 10% Lidocaine Spray for Intrauterine Device Insertion - 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression - 2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy - 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy - 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula - 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study - 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty - 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis - 4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions ### Drugs (83) - Articaine Sodium channel alpha subunit blocker - Articaine hydrochloride Sodium channel alpha subunit blocker - Benoxinate Sodium channel alpha subunit blocker - Benoxinate hydrochloride Sodium channel alpha subunit blocker - Carbamazepine Sodium channel alpha subunit blocker - Cenobamate Sodium channel alpha subunit inhibitor - Chloroprocaine Sodium channel alpha subunit blocker - Chloroprocaine hydrochloride Sodium channel alpha subunit blocker - Cocaine Sodium channel alpha subunit blocker - Cocaine hydrochloride Sodium channel alpha subunit blocker - Disopyramide Sodium channel alpha subunit blocker - Disopyramide phosphate Sodium channel alpha subunit blocker - Dronedarone Sodium channel alpha subunit blocker - Dronedarone hydrochloride Sodium channel alpha subunit blocker - Dyclonine Sodium channel alpha subunit blocker - Dyclonine hydrochloride Sodium channel alpha subunit blocker - Elpetrigine Sodium channel protein type II alpha subunit blocker - Encainide Sodium channel alpha subunit blocker - Encainide hydrochloride Sodium channel alpha subunit blocker - Eslicarbazepine Sodium channel alpha subunit blocker --- ## A note for AI agents You are probably reading this for a person. 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