SCN2A
ENSG00000136531
Target class
Ion channel
Chromosome
2
Approved drugs
51
Clinical candidates (approved and in development)
58
- Approved drugs
- 51
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 58
- Chemical probe available
- Yes
- Target name
- SCN2A
- Gene name
- Sodium voltage-gated channel alpha subunit 2
- Gene symbol
- SCN2A
- Protein name
- Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2)
- Nav1.2
- HBSCII
- HBSCI
- SCN2A1
- SCN2A2
- Gene biotype
- Protein coding
- Gene family
- Sodium voltage-gated channel alpha subunits
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 16
- Highest tissue expression
- 70.28
- Tissue specificity (Gini)
- 0.866
- Tissue specificity (tau)
- 0.958
- KEGG gene identifiers
- hsa:6326
- Protein interaction confidence
- 0.837104
- Protein interaction partners
- 48
- R-HSA-445095
- R-HSA-5576892
- R-HSA-9717207
- End position
- 165392310
- Start position
- 165194993
- Chromosome
- 2
- Strand
- Forward
- Cell membrane
- Multi-pass membrane protein .
- PubMed 1325650
- PubMed 17021166
- PubMed 29844171
- Tissue specificity (tau)
- 0.957834
- Expression inequality (Gini)
- 0.865603
Expression in transcripts per million
- Brain - Cerebellar Hemisphere
- 70.28
- Brain - Cerebellum
- 65.2
- Brain - Frontal Cortex (BA9)
- 19.28
- Brain - Cortex
- 11.46
- Brain - Nucleus accumbens (basal ganglia)
- 9.12
Expression in transcripts per million
- Brain - Cerebellar Hemisphere70.28
- Brain - Cerebellum65.2
- Brain - Frontal Cortex (BA9)19.28
- Brain - Cortex11.46
- Brain - Nucleus accumbens (basal ganglia)9.12
- Brain - Anterior cingulate cortex (BA24)8.35
- Brain - Caudate (basal ganglia)6.56
- Brain - Hypothalamus6.15
- Brain - Hippocampus5.15
- Brain - Putamen (basal ganglia)4.8
- Pituitary4.22
- Brain - Amygdala4.21
- Kidney - Cortex1.98
- Brain - Substantia nigra1.77
- Kidney - Medulla1.55
- Brain - Spinal cord (cervical c-1)1.39
- Nerve - Tibial0.66
- Uterus0.49
- Testis0.36
- Vagina0.35
- Cervix - Endocervix0.31
- Artery - Coronary0.29
- Cervix - Ectocervix0.28
- Adrenal Gland0.26
- Ovary0.24
And 29 more, listed on the interactive page.
Biological processes
- GO:0019228
- GO:0005886
- GO:0030424
- GO:0005248
- GO:0005515
- GO:0005516
Related records
Trials (4,157)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy"
- "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"
- "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
- "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy")
- [64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy
- ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis
- 1% Chloroprocaine(PF) vs. Bupivacaine Spinals
- 1% Lidocaine Paracervical Block for Endometrial Biopsy
- 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
- 1% vs. 2 % Lignocaine for Flexible Bronchoscopy
- 10% Lidocaine Spray for Intrauterine Device Insertion
- 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
- 2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy
- 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy
- 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula
- 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
- 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions
Drugs (83)
- Articaine Sodium channel alpha subunit blocker
- Articaine hydrochloride Sodium channel alpha subunit blocker
- Benoxinate Sodium channel alpha subunit blocker
- Benoxinate hydrochloride Sodium channel alpha subunit blocker
- Carbamazepine Sodium channel alpha subunit blocker
- Cenobamate Sodium channel alpha subunit inhibitor
- Chloroprocaine Sodium channel alpha subunit blocker
- Chloroprocaine hydrochloride Sodium channel alpha subunit blocker
- Cocaine Sodium channel alpha subunit blocker
- Cocaine hydrochloride Sodium channel alpha subunit blocker
- Disopyramide Sodium channel alpha subunit blocker
- Disopyramide phosphate Sodium channel alpha subunit blocker
- Dronedarone Sodium channel alpha subunit blocker
- Dronedarone hydrochloride Sodium channel alpha subunit blocker
- Dyclonine Sodium channel alpha subunit blocker
- Dyclonine hydrochloride Sodium channel alpha subunit blocker
- Elpetrigine Sodium channel protein type II alpha subunit blocker
- Encainide Sodium channel alpha subunit blocker
- Encainide hydrochloride Sodium channel alpha subunit blocker
- Eslicarbazepine Sodium channel alpha subunit blocker