SCN1A
ENSG00000144285
Target class
Ion channel
Chromosome
2
Approved drugs
51
Clinical candidates (approved and in development)
57
- Approved drugs
- 51
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 57
- Chemical probe available
- Yes
- Target name
- SCN1A
- Gene name
- Sodium voltage-gated channel alpha subunit 1
- Gene symbol
- SCN1A
- Protein name
- Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)
- Nav1.1
- GEFSP2
- HBSCI
- NAC1
- SMEI
- SCN1
- FEB3
- Gene biotype
- Protein coding
- Gene family
- Sodium voltage-gated channel alpha subunits
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 14
- Protein localisation evidence grade
- Supported
- Highest tissue expression
- 15.14
- Tissue specificity (Gini)
- 0.822
- Tissue specificity (tau)
- 0.916
- KEGG gene identifiers
- hsa:6323
- Protein interaction confidence
- 0.816186
- Protein interaction partners
- 43
- R-HSA-445095
- R-HSA-5576892
- End position
- 166182806
- Start position
- 165984641
- Chromosome
- 2
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein .
- Nuclear bodies
- Nucleoplasm
- Plasma membrane
- PubMed 14672992
- PubMed 17928445
- PubMed 33712547
- Tissue specificity (tau)
- 0.915668
- Expression inequality (Gini)
- 0.822192
Expression in transcripts per million
- Brain - Frontal Cortex (BA9)
- 15.14
- Brain - Cerebellar Hemisphere
- 10.71
- Brain - Cerebellum
- 9.25
- Brain - Cortex
- 8.87
- Brain - Hypothalamus
- 6.33
Expression in transcripts per million
- Brain - Frontal Cortex (BA9)15.14
- Brain - Cerebellar Hemisphere10.71
- Brain - Cerebellum9.25
- Brain - Cortex8.87
- Brain - Hypothalamus6.33
- Brain - Anterior cingulate cortex (BA24)5.71
- Brain - Caudate (basal ganglia)4.82
- Brain - Nucleus accumbens (basal ganglia)4.65
- Brain - Hippocampus3.65
- Brain - Putamen (basal ganglia)3.57
- Brain - Amygdala3.19
- Brain - Substantia nigra2.56
- Brain - Spinal cord (cervical c-1)1.74
- Lung1.59
- Cells - Cultured fibroblasts0.3
- Testis0.18
- Pituitary0.08
- Colon - Sigmoid0.05
- Heart - Left Ventricle0.03
- Cervix - Endocervix0.03
- Fallopian Tube0.03
- Colon - Transverse0.02
- Cervix - Ectocervix0.02
- Heart - Atrial Appendage0.02
- Adrenal Gland0.01
And 29 more, listed on the interactive page.
- GO:0086002
- GO:0086010
Cellular components
- GO:0005886
- GO:0005248
- GO:0099508
Increased, amputations
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourceReduced, feeding 1
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourceIncreased, predation
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourceReduced, survival
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourceIncreased, predation
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence source
Related records
Trials (4,157)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy"
- "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"
- "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
- "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy")
- [64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy
- ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis
- 1% Chloroprocaine(PF) vs. Bupivacaine Spinals
- 1% Lidocaine Paracervical Block for Endometrial Biopsy
- 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
- 1% vs. 2 % Lignocaine for Flexible Bronchoscopy
- 10% Lidocaine Spray for Intrauterine Device Insertion
- 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
- 2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy
- 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy
- 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula
- 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
- 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions
Drugs (82)
- Articaine Sodium channel alpha subunit blocker
- Articaine hydrochloride Sodium channel alpha subunit blocker
- Benoxinate Sodium channel alpha subunit blocker
- Benoxinate hydrochloride Sodium channel alpha subunit blocker
- Carbamazepine Sodium channel alpha subunit blocker
- Cenobamate Sodium channel alpha subunit inhibitor
- Chloroprocaine Sodium channel alpha subunit blocker
- Chloroprocaine hydrochloride Sodium channel alpha subunit blocker
- Cocaine Sodium channel alpha subunit blocker
- Cocaine hydrochloride Sodium channel alpha subunit blocker
- Disopyramide Sodium channel alpha subunit blocker
- Disopyramide phosphate Sodium channel alpha subunit blocker
- Dronedarone Sodium channel alpha subunit blocker
- Dronedarone hydrochloride Sodium channel alpha subunit blocker
- Dyclonine Sodium channel alpha subunit blocker
- Dyclonine hydrochloride Sodium channel alpha subunit blocker
- Encainide Sodium channel alpha subunit blocker
- Encainide hydrochloride Sodium channel alpha subunit blocker
- Eslicarbazepine Sodium channel alpha subunit blocker
- Eslicarbazepine acetate Sodium channel alpha subunit blocker