SCN11A
ENSG00000168356
Target class
Ion channel
Chromosome
3
Approved drugs
51
Clinical candidates (approved and in development)
58
- Approved drugs
- 51
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 58
- Chemical probe available
- No
- Target name
- SCN11A
- Gene name
- Sodium voltage-gated channel alpha subunit 11
- Gene symbol
- SCN11A
- Previous gene symbols
- SCN12A
- Protein name
- Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN)
- Nav1.9
- NaN
- SNS-2
- Gene biotype
- Protein coding
- Gene family
- Sodium voltage-gated channel alpha subunits
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 3
- Highest tissue expression
- 3.25
- Tissue specificity (Gini)
- 0.52
- Tissue specificity (tau)
- 0.894
- KEGG gene identifiers
- hsa:11280
- Protein interaction confidence
- 0.805667
- Protein interaction partners
- 15
- R-HSA-445095
- R-HSA-5576892
- End position
- 39052157
- Start position
- 38845764
- Chromosome
- 3
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein .
- PubMed 12384689
- PubMed 24036948
- Tissue specificity (tau)
- 0.894165
- Expression inequality (Gini)
- 0.520036
Expression in transcripts per million
- Spleen
- 3.25
- Testis
- 3
- Colon - Sigmoid
- 1.06
- Nerve - Tibial
- 0.75
- Adipose - Subcutaneous
- 0.65
Expression in transcripts per million
- Spleen3.25
- Testis3
- Colon - Sigmoid1.06
- Nerve - Tibial0.75
- Adipose - Subcutaneous0.65
- Colon - Transverse0.61
- Small Intestine - Terminal Ileum0.58
- Breast - Mammary Tissue0.58
- Adipose - Visceral (Omentum)0.57
- Bladder0.56
- Brain - Nucleus accumbens (basal ganglia)0.49
- Pituitary0.48
- Brain - Spinal cord (cervical c-1)0.47
- Kidney - Medulla0.45
- Brain - Caudate (basal ganglia)0.44
- Esophagus - Muscularis0.4
- Brain - Cortex0.37
- Brain - Amygdala0.37
- Brain - Hypothalamus0.36
- Esophagus - Gastroesophageal Junction0.36
- Thyroid0.34
- Brain - Putamen (basal ganglia)0.33
- Brain - Frontal Cortex (BA9)0.31
- Brain - Substantia nigra0.29
- Brain - Anterior cingulate cortex (BA24)0.28
And 29 more, listed on the interactive page.
- GO:0019233
- GO:0086010
- GO:0005886
- GO:0070062
Molecular functions
- GO:0005248
Related records
Trials (4,158)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy"
- "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"
- "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
- "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy")
- [64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy
- ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis
- 1% Chloroprocaine(PF) vs. Bupivacaine Spinals
- 1% Lidocaine Paracervical Block for Endometrial Biopsy
- 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
- 1% vs. 2 % Lignocaine for Flexible Bronchoscopy
- 10% Lidocaine Spray for Intrauterine Device Insertion
- 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
- 2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy
- 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy
- 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula
- 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
- 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions
Drugs (83)
- Afacifenacin Sodium channel protein type XI alpha subunit blocker
- Articaine Sodium channel alpha subunit blocker
- Articaine hydrochloride Sodium channel alpha subunit blocker
- Benoxinate Sodium channel alpha subunit blocker
- Benoxinate hydrochloride Sodium channel alpha subunit blocker
- Carbamazepine Sodium channel alpha subunit blocker
- Cenobamate Sodium channel alpha subunit inhibitor
- Chloroprocaine Sodium channel alpha subunit blocker
- Chloroprocaine hydrochloride Sodium channel alpha subunit blocker
- Cocaine Sodium channel alpha subunit blocker
- Cocaine hydrochloride Sodium channel alpha subunit blocker
- Disopyramide Sodium channel alpha subunit blocker
- Disopyramide phosphate Sodium channel alpha subunit blocker
- Dronedarone Sodium channel alpha subunit blocker
- Dronedarone hydrochloride Sodium channel alpha subunit blocker
- Dyclonine Sodium channel alpha subunit blocker
- Dyclonine hydrochloride Sodium channel alpha subunit blocker
- Encainide Sodium channel alpha subunit blocker
- Encainide hydrochloride Sodium channel alpha subunit blocker
- Eslicarbazepine Sodium channel alpha subunit blocker