> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/scn10a-e64e3928-416a-5e6d-b348-81c46298a289 > Record changed: 2026-10-13 # SCN10A ENSG00000185313 Target class Ion channel Chromosome 3 Approved drugs 52 Clinical candidates (approved and in development) 61 ## Clinical evidence **Approved drugs** 52 **ClinGen gene-disease validity** Disputed **Clinical candidates (approved and in development)** 61 ## Druggability **Chemical probe available** Yes ## Names **Target name** SCN10A **Gene name** Sodium voltage-gated channel alpha subunit 10 **Gene symbol** SCN10A **Protein name** Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) ### Other names (4) - Nav1.8 - hPN3 - SNS - PN3 ## Classification **Gene biotype** Protein coding **Gene family** Sodium voltage-gated channel alpha subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 0 **Protein localisation evidence grade** Approved **Highest tissue expression** 0.46 **Tissue specificity (Gini)** 0.933 **Tissue specificity (tau)** 0.989 ## Pathways and interactions **KEGG gene identifiers** - hsa:6336 **Protein interaction confidence** 0.7976 **Protein interaction partners** 25 ### Reactome pathways (2) - R-HSA-445095 - R-HSA-5576892 ## Genomic location **End position** 38816286 **Start position** 38696802 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000185313 **HGNC ID** HGNC:10582 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10582) **NCBI Gene ID** 6336 **UniProt ID** Q9Y5Y9 ## Cellular location - Cell membrane - Multi-pass membrane protein . Note=It can be translocated to the cell membrane through association with S100A10\. . - Connecting piece - Flagellar centriole ## Tissue expression **Tissue specificity (tau)** 0.988925 **Expression inequality (Gini)** 0.933283 ### Highest expression Expression in transcripts per million **Testis** 0.46 **Heart - Atrial Appendage** 0.07 **Artery - Aorta** 0.06 **Heart - Left Ventricle** 0.04 **Artery - Coronary** 0.02 ### All tissues (54) Expression in transcripts per million - Testis0.46 - Heart - Atrial Appendage0.07 - Artery - Aorta0.06 - Heart - Left Ventricle0.04 - Artery - Coronary0.02 - Artery - Tibial0.02 - Cervix - Endocervix0.02 - Spleen0.01 - Brain - Frontal Cortex (BA9)0.01 - Brain - Cortex0.01 - Brain - Spinal cord (cervical c-1)0.01 - Kidney - Medulla0 - Pituitary0 - Whole Blood0 - Esophagus - Muscularis0 - Brain - Cerebellar Hemisphere0 - Adrenal Gland0 - Brain - Caudate (basal ganglia)0 - Vagina0 - Brain - Substantia nigra0 - Liver0 - Brain - Putamen (basal ganglia)0 - Muscle - Skeletal0 - Skin - Not Sun Exposed (Suprapubic)0 - Small Intestine - Terminal Ileum0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0002027 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002027) - GO:0007600 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007600) - GO:0034765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034765) - GO:0035725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035725) - GO:0055117 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055117) - GO:0060371 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060371) - GO:0086010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086010) - GO:0086016 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086016) - GO:0086043 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086043) ### Cellular components (3) - GO:0001518 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001518) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (2) - GO:0005248 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005248) - GO:0044325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044325) ## Related records ### Trials (4,163) - : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic - "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy" - "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome" - "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age." - "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy") - \[64Cu\]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy - ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis - 1% Chloroprocaine(PF) vs. Bupivacaine Spinals - 1% Lidocaine Paracervical Block for Endometrial Biopsy - 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration - 1% vs. 2 % Lignocaine for Flexible Bronchoscopy - 10% Lidocaine Spray for Intrauterine Device Insertion - 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression - 2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy - 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy - 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula - 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study - 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty - 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis - 4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions ### Drugs (87) - Afacifenacin Sodium channel protein type X alpha subunit blocker - Articaine Sodium channel alpha subunit blocker - Articaine hydrochloride Sodium channel alpha subunit blocker - Benoxinate Sodium channel alpha subunit blocker - Benoxinate hydrochloride Sodium channel alpha subunit blocker - Carbamazepine Sodium channel alpha subunit blocker - Cenobamate Sodium channel alpha subunit inhibitor - Chloroprocaine Sodium channel alpha subunit blocker - Chloroprocaine hydrochloride Sodium channel alpha subunit blocker - Cocaine Sodium channel alpha subunit blocker - Cocaine hydrochloride Sodium channel alpha subunit blocker - Dibucaine Sodium channel protein type X alpha subunit blocker - Dibucaine hydrochloride Sodium channel protein type X alpha subunit blocker - Disopyramide Sodium channel alpha subunit blocker - Disopyramide phosphate Sodium channel alpha subunit blocker - Dronedarone Sodium channel alpha subunit blocker - Dronedarone hydrochloride Sodium channel alpha subunit blocker - DSP-2230 Sodium channel protein type X alpha subunit blocker - Dyclonine Sodium channel alpha subunit blocker - Dyclonine hydrochloride Sodium channel alpha subunit blocker --- ## A note for AI agents You are probably reading this for a person. 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