SCN10A
ENSG00000185313
Target class
Ion channel
Chromosome
3
Approved drugs
52
Clinical candidates (approved and in development)
61
- Approved drugs
- 52
- ClinGen gene-disease validity
- Disputed
- Clinical candidates (approved and in development)
- 61
- Chemical probe available
- Yes
- Target name
- SCN10A
- Gene name
- Sodium voltage-gated channel alpha subunit 10
- Gene symbol
- SCN10A
- Protein name
- Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)
- Nav1.8
- hPN3
- SNS
- PN3
- Gene biotype
- Protein coding
- Gene family
- Sodium voltage-gated channel alpha subunits
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 0
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 0.46
- Tissue specificity (Gini)
- 0.933
- Tissue specificity (tau)
- 0.989
- KEGG gene identifiers
- hsa:6336
- Protein interaction confidence
- 0.7976
- Protein interaction partners
- 25
- R-HSA-445095
- R-HSA-5576892
- End position
- 38816286
- Start position
- 38696802
- Chromosome
- 3
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein . Note=It can be translocated to the cell membrane through association with S100A10. .
- Connecting piece
- Flagellar centriole
- Tissue specificity (tau)
- 0.988925
- Expression inequality (Gini)
- 0.933283
Expression in transcripts per million
- Testis
- 0.46
- Heart - Atrial Appendage
- 0.07
- Artery - Aorta
- 0.06
- Heart - Left Ventricle
- 0.04
- Artery - Coronary
- 0.02
Expression in transcripts per million
- Testis0.46
- Heart - Atrial Appendage0.07
- Artery - Aorta0.06
- Heart - Left Ventricle0.04
- Artery - Coronary0.02
- Artery - Tibial0.02
- Cervix - Endocervix0.02
- Spleen0.01
- Brain - Frontal Cortex (BA9)0.01
- Brain - Cortex0.01
- Brain - Spinal cord (cervical c-1)0.01
- Kidney - Medulla0
- Pituitary0
- Whole Blood0
- Esophagus - Muscularis0
- Brain - Cerebellar Hemisphere0
- Adrenal Gland0
- Brain - Caudate (basal ganglia)0
- Vagina0
- Brain - Substantia nigra0
- Liver0
- Brain - Putamen (basal ganglia)0
- Muscle - Skeletal0
- Skin - Not Sun Exposed (Suprapubic)0
- Small Intestine - Terminal Ileum0
And 29 more, listed on the interactive page.
- GO:0002027
- GO:0007600
- GO:0034765
- GO:0035725
- GO:0055117
- GO:0060371
- GO:0086010
- GO:0086016
- GO:0086043
- GO:0001518
- GO:0005886
- GO:0070062
- GO:0005248
- GO:0044325
Related records
Trials (4,163)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- "Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy"
- "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"
- "Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
- "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy")
- [64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy
- ยง Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis
- 1% Chloroprocaine(PF) vs. Bupivacaine Spinals
- 1% Lidocaine Paracervical Block for Endometrial Biopsy
- 1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
- 1% vs. 2 % Lignocaine for Flexible Bronchoscopy
- 10% Lidocaine Spray for Intrauterine Device Insertion
- 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
- 2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy
- 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy
- 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula
- 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
- 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions
Drugs (87)
- Afacifenacin Sodium channel protein type X alpha subunit blocker
- Articaine Sodium channel alpha subunit blocker
- Articaine hydrochloride Sodium channel alpha subunit blocker
- Benoxinate Sodium channel alpha subunit blocker
- Benoxinate hydrochloride Sodium channel alpha subunit blocker
- Carbamazepine Sodium channel alpha subunit blocker
- Cenobamate Sodium channel alpha subunit inhibitor
- Chloroprocaine Sodium channel alpha subunit blocker
- Chloroprocaine hydrochloride Sodium channel alpha subunit blocker
- Cocaine Sodium channel alpha subunit blocker
- Cocaine hydrochloride Sodium channel alpha subunit blocker
- Dibucaine Sodium channel protein type X alpha subunit blocker
- Dibucaine hydrochloride Sodium channel protein type X alpha subunit blocker
- Disopyramide Sodium channel alpha subunit blocker
- Disopyramide phosphate Sodium channel alpha subunit blocker
- Dronedarone Sodium channel alpha subunit blocker
- Dronedarone hydrochloride Sodium channel alpha subunit blocker
- DSP-2230 Sodium channel protein type X alpha subunit blocker
- Dyclonine Sodium channel alpha subunit blocker
- Dyclonine hydrochloride Sodium channel alpha subunit blocker