> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ryr3-912d561b-099d-5c59-9706-e00ba688493b > Record changed: 2026-11-04 # RYR3 ENSG00000198838 Target class Ion channel Chromosome 15 Approved drugs 1 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Limited **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** No ## Names **Target name** RYR3 **Gene name** Ryanodine receptor 3 **Gene symbol** RYR3 **Protein name** Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor) ## Classification **Gene biotype** Protein coding **Gene family** Ryanodine receptors|EF-hand domain containing **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 35 **Protein localisation evidence grade** Approved **Highest tissue expression** 9.55 **Tissue specificity (Gini)** 0.5 **Tissue specificity (tau)** 0.733 ## Pathways and interactions **KEGG gene identifiers** - hsa:6263 **Protein interaction confidence** 0.924789 **Protein interaction partners** 19 ### Reactome pathways (2) - R-HSA-2672351 - R-HSA-5578775 ## Genomic location **End position** 33866121 **Start position** 33310962 **Chromosome** 15 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000198838 **HGNC ID** HGNC:10485 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10485) **NCBI Gene ID** 6263 **UniProt ID** Q15413 ## Cellular location - Sarcoplasmic reticulum membrane - Multi-pass membrane protein . - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.733024 **Expression inequality (Gini)** 0.500084 ### Highest expression Expression in transcripts per million **Uterus** 9.55 **Brain - Caudate (basal ganglia)** 7.75 **Brain - Putamen (basal ganglia)** 7.32 **Colon - Sigmoid** 7.26 **Muscle - Skeletal** 6.88 ### All tissues (54) Expression in transcripts per million - Uterus9.55 - Brain - Caudate (basal ganglia)7.75 - Brain - Putamen (basal ganglia)7.32 - Colon - Sigmoid7.26 - Muscle - Skeletal6.88 - Brain - Cortex6.74 - Brain - Nucleus accumbens (basal ganglia)6.68 - Brain - Anterior cingulate cortex (BA24)6.24 - Brain - Amygdala5.82 - Fallopian Tube5.36 - Brain - Frontal Cortex (BA9)5.11 - Cervix - Endocervix4.97 - Brain - Cerebellum4.68 - Esophagus - Gastroesophageal Junction3.86 - Brain - Hippocampus3.77 - Artery - Aorta3.65 - Artery - Tibial3.38 - Esophagus - Muscularis3.2 - Bladder3.17 - Brain - Substantia nigra3.11 - Brain - Cerebellar Hemisphere2.94 - Cervix - Ectocervix2.9 - Nerve - Tibial2.52 - Brain - Hypothalamus2.46 - Testis2.31 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0006816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006816) ### Cellular components - GO:0033017 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033017) ### Molecular functions (2) - GO:0005219 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005219) - GO:0015278 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015278) ## Related records ### Trials (231) - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome - A Clinical Trial Utilizing Dantrolene in Patients With Ventricular Arrhythmias. - A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors - A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine - A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin - A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants - A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects - A Possible Therapeutic Role for Adenosine During Inflammation - A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005) - A Study Evaluating the Potential of BMS-984923 to Alter the Systemic Exposure of Three Orally Administered Probe Substrates - A Study of Caffeine on Cardiac Arrhythmias - A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants - A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis - [A Study of LY4515100 in Healthy Participants](https://trialight.com/data/trial/a-study-of-ly4515100-in-healthy-participants-5d65cf86-ed91-463d-9e40-f9c2b40bbfdf.md) - A Study to Assess Effect of JNJ-54861911 on Pharmacokinetics of Cocktail Representatives for Cytochrome P450 (CYP) 3A4, CYP2B6, CYP2C9, and CYP1A2 Substrates - A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants - A Study to Compare How Different Substances (Caffeine, Warfarin, Omeprazole, Metoprolol, and Midazolam) Are Handled by the Body of Healthy People and People With Liver Cirrhosis - A Study to Determine if Caffeine Accelerates Emergence From Anesthesia - A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia ### Drugs (4) - Adenosine triphosphate - [Caffeine](https://trialight.com/data/asset/caffeine-4062cceb-b322-4d67-b5b1-c5c5913c8897.md) - Dantrolene Ryanodine receptor 3 antagonist - Dantrolene sodium Ryanodine receptor 3 antagonist --- ## A note for AI agents You are probably reading this for a person. 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